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    Nek3 NIMA (never in mitosis gene a)-related expressed kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 23954, updated on 5-Sep-2021

    Summary

    Official Symbol
    Nek3provided by MGI
    Official Full Name
    NIMA (never in mitosis gene a)-related expressed kinase 3provided by MGI
    Primary source
    MGI:MGI:1344371
    See related
    Ensembl:ENSMUSG00000031478
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in bladder adult (RPKM 2.5), CNS E11.5 (RPKM 2.4) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Nek3 in Genome Data Viewer
    Location:
    8 A2; 8 11.07 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22618299..22657009, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22128283..22166997, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (23238755..23276907, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene asparagine-linked glycosylation 11 (alpha-1,2-mannosyltransferase) Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 5 Neighboring gene small nucleolar RNA U13 Neighboring gene cytoskeleton associated protein 2 Neighboring gene predicted gene, 29878

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of tubulin deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase Nek3
    Names
    NIMA-related expressed kinase 3
    never in mitosis A-related kinase 3
    nimA-related protein kinase 3
    NP_001156419.1
    NP_035978.2
    XP_006509174.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162947.1NP_001156419.1  serine/threonine-protein kinase Nek3 isoform 1

      See identical proteins and their annotated locations for NP_001156419.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC117665
      Consensus CDS
      CCDS52519.1
      UniProtKB/Swiss-Prot
      Q9R0A5
      Related
      ENSMUSP00000136876.2, ENSMUST00000178324.2
      Conserved Domains (1) summary
      cl21453
      Location:3255
      PKc_like; Protein Kinases, catalytic domain
    2. NM_011848.4NP_035978.2  serine/threonine-protein kinase Nek3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter isoform (2) compared to isoform 1.
      Source sequence(s)
      AC117665, BU058938, CV560683
      Consensus CDS
      CCDS22169.1
      UniProtKB/TrEMBL
      F8WGD4
      Related
      ENSMUSP00000033865.10, ENSMUST00000033865.16
      Conserved Domains (2) summary
      smart00220
      Location:4250
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:3255
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      22618299..22657009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509111.5XP_006509174.1  serine/threonine-protein kinase Nek3 isoform X1

      See identical proteins and their annotated locations for XP_006509174.1

      UniProtKB/Swiss-Prot
      Q9R0A5
      Related
      ENSMUSP00000106358.4, ENSMUST00000110730.10
      Conserved Domains (1) summary
      cl21453
      Location:3255
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_378785.5 RNA Sequence

    2. XR_003947272.2 RNA Sequence

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