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    Snca synuclein, alpha [ Mus musculus (house mouse) ]

    Gene ID: 20617, updated on 19-Sep-2021

    Summary

    Official Symbol
    Sncaprovided by MGI
    Official Full Name
    synuclein, alphaprovided by MGI
    Primary source
    MGI:MGI:1277151
    See related
    Ensembl:ENSMUSG00000025889
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    al; alp; NACP; alphaSYN; alpha-Syn
    Expression
    Biased expression in liver E14 (RPKM 144.4), liver E14.5 (RPKM 119.8) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Snca in Genome Data Viewer
    Location:
    6 B3; 6 29.15 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (60708557..60806839, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (60731573..60829855, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (60681567..60779849, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38823 Neighboring gene predicted gene, 35386 Neighboring gene MAGE family member B16, pseudogene 2 Neighboring gene multimerin 1 Neighboring gene protein phosphatase 6, catalytic subunit pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (9)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SNARE binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables arachidonic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables copper ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cuprous ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cuprous ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    enables dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ferrous iron binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tau protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in SNARE complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in SNARE complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within adult locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in behavioral response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to copper ion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within chemical synaptic transmission IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within dopamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dopamine metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within microglial cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitochondrial ATP synthesis coupled electron transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitochondrial membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of chaperone-mediated autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of dopamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of dopamine uptake involved in synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of histone acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of norepinephrine uptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of serotonin uptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of thrombin-activated receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neutral lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phospholipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of SNARE complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hydrogen peroxide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of neurotransmitter secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein complex oligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein tetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of acyl-CoA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of acyl-CoA biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of dopamine secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of dopamine secretion TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within regulation of glutamate secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of macrophage activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT acts_upstream_of_or_within regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neuron death IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of neurotransmitter secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of norepinephrine uptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of phospholipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to interferon-gamma ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to iron(II) ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to magnesium ion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within synapse organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within synaptic transmission, dopaminergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic vesicle endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic vesicle priming ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in axon terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in inclusion body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in neuronal cell body IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with platelet alpha granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in supramolecular fiber ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    alpha-synuclein
    Names
    non-A beta component of AD amyloid
    non-A4 component of amyloid

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042451.2NP_001035916.1  alpha-synuclein

      See identical proteins and their annotated locations for NP_001035916.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC046764, BY782503
      Consensus CDS
      CCDS20201.1
      UniProtKB/Swiss-Prot
      O55042
      Related
      ENSMUSP00000109907.4, ENSMUST00000114268.5
      Conserved Domains (1) summary
      pfam01387
      Location:1131
      Synuclein
    2. NM_009221.2NP_033247.1  alpha-synuclein

      See identical proteins and their annotated locations for NP_033247.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF179273, BC046764
      Consensus CDS
      CCDS20201.1
      UniProtKB/Swiss-Prot
      O55042
      Related
      ENSMUSP00000126067.2, ENSMUST00000163779.8
      Conserved Domains (1) summary
      pfam01387
      Location:1131
      Synuclein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      60708557..60806839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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