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    Cfhr4 complement factor H-related 4 [ Mus musculus (house mouse) ]

    Gene ID: 214403, updated on 23-Jun-2021

    Summary

    Official Symbol
    Cfhr4provided by MGI
    Official Full Name
    complement factor H-related 4provided by MGI
    Primary source
    MGI:MGI:3646434
    See related
    Ensembl:ENSMUSG00000070594
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cfhrc; Gm4788; EG214403
    Expression
    Biased expression in liver adult (RPKM 14.7), liver E18 (RPKM 8.8) and 7 other tissues See more
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    Genomic context

    See Cfhr4 in Genome Data Viewer
    Location:
    1; 1 F
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (139625657..139708977, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (139697919..139781239, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (141594496..141677816, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene complement factor H-related 3 Neighboring gene predicted gene, 26271 Neighboring gene predicted gene, 25619 Neighboring gene predicted gene, 41963

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Potential readthrough

    Included gene: Cfhr3

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables complement component C3b binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables heparan sulfate proteoglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in regulation of complement activation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    complement factor H-related protein C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029977.3NP_001025148.3  complement factor H-related protein C isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC115748, AJ871401, BC145444
      Consensus CDS
      CCDS35730.1
      UniProtKB/TrEMBL
      B2RUG5, E9Q8B5, Q0KHD3
      Related
      ENSMUSP00000107620.3, ENSMUST00000111989.9
      Conserved Domains (3) summary
      cd00033
      Location:759813
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:208448
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:512565
      Sushi; Sushi repeat (SCR repeat)
    2. NM_001160303.1NP_001153775.1  complement factor H-related protein C isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC115748, AC165300, BC145444
      UniProtKB/TrEMBL
      B2RUG5
      Related
      ENSMUSP00000027612.9, ENSMUST00000027612.11
      Conserved Domains (3) summary
      cd00033
      Location:758812
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:208447
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:511564
      Sushi; Sushi repeat (SCR repeat)
    3. NM_001160304.1NP_001153776.1  complement factor H-related protein C isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC115748, AJ871402, BC013664, BC145444
      Consensus CDS
      CCDS48387.1
      UniProtKB/TrEMBL
      B2RUG5, E9Q8B6, Q0KHD2
      Related
      ENSMUSP00000107617.3, ENSMUST00000111986.8
      Conserved Domains (3) summary
      cd00033
      Location:700754
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:510755
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:512565
      Sushi; Sushi repeat (SCR repeat)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      139625657..139708977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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