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    Plcz1 phospholipase C, zeta 1 [ Mus musculus (house mouse) ]

    Gene ID: 114875, updated on 27-Jul-2021

    Summary

    Official Symbol
    Plcz1provided by MGI
    Official Full Name
    phospholipase C, zeta 1provided by MGI
    Primary source
    MGI:MGI:2150308
    See related
    Ensembl:ENSMUSG00000030230
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PLCzeta; 1700041H07Rik
    Expression
    Restricted expression toward testis adult (RPKM 21.0) See more
    Orthologs
    NEW
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    Genomic context

    See Plcz1 in Genome Data Viewer
    Location:
    6; 6 G2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (139933118..139987188, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (139987396..140041488, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (139938243..139989938, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma Neighboring gene predicted gene, 53305 Neighboring gene capping protein (actin filament) muscle Z-line, alpha 3 Neighboring gene predicted gene, 44156

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC123405, MGC123406

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylinositol phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-5-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within egg activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in egg activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration involved in egg activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration involved in egg activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration involved in egg activation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within single fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm head ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
    Names
    PLC-zeta-1
    phosphoinositide phospholipase C-zeta-1
    phospholipase C zeta
    NP_473407.2
    XP_006506962.1
    XP_006506963.1
    XP_006506964.1
    XP_006506965.1
    XP_006506967.1
    XP_017176832.1
    XP_030110971.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_054066.4NP_473407.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

      See identical proteins and their annotated locations for NP_473407.2

      Status: PROVISIONAL

      Source sequence(s)
      AC158625
      Consensus CDS
      CCDS20671.1
      UniProtKB/Swiss-Prot
      Q8K4D7
      Related
      ENSMUSP00000032356.7, ENSMUST00000032356.13
      Conserved Domains (4) summary
      cd00275
      Location:519644
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      PLN02952
      Location:79642
      PLN02952; phosphoinositide phospholipase C
      pfam09279
      Location:80162
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl14615
      Location:162489
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      139933118..139987188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506899.5XP_006506962.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1

      Conserved Domains (3) summary
      PLN02952
      Location:79614
      PLN02952; phosphoinositide phospholipase C
      pfam13499
      Location:2173
      EF-hand_7; EF-hand domain pair
      cl14615
      Location:162489
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    2. XM_017321343.3XP_017176832.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X4

      Conserved Domains (4) summary
      cd00275
      Location:409527
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd15898
      Location:740
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:240
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl14615
      Location:52379
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    3. XM_006506902.5XP_006506965.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X4

      Conserved Domains (4) summary
      cd00275
      Location:409527
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd15898
      Location:740
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:240
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl14615
      Location:52379
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    4. XM_006506904.5XP_006506967.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X6

      Conserved Domains (2) summary
      PLN02952
      Location:1347
      PLN02952; phosphoinositide phospholipase C
      cl14615
      Location:1222
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    5. XM_006506900.5XP_006506963.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X2

      Conserved Domains (3) summary
      PLN02952
      Location:79614
      PLN02952; phosphoinositide phospholipase C
      pfam13499
      Location:2173
      EF-hand_7; EF-hand domain pair
      cl14615
      Location:162489
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    6. XM_006506901.5XP_006506964.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X3

      Conserved Domains (3) summary
      PLN02952
      Location:79619
      PLN02952; phosphoinositide phospholipase C
      pfam13499
      Location:2573
      EF-hand_7; EF-hand domain pair
      cl14615
      Location:162489
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    7. XM_030255111.2XP_030110971.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X5

      Conserved Domains (2) summary
      PLN02222
      Location:7532
      PLN02222; phosphoinositide phospholipase C 2
      cl14615
      Location:52379
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
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