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    Ttpa tocopherol (alpha) transfer protein [ Mus musculus (house mouse) ]

    Gene ID: 50500, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ttpaprovided by MGI
    Official Full Name
    tocopherol (alpha) transfer proteinprovided by MGI
    Primary source
    MGI:MGI:1354168
    See related
    Ensembl:ENSMUSG00000073988
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    alph; alpha-TTP
    Expression
    Biased expression in liver adult (RPKM 49.2) and liver E18 (RPKM 17.0) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ttpa in Genome Data Viewer
    Location:
    4 A3; 4 7.76 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (20007867..20030822)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (20007894..20030822)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (19935575..19957932)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit D2 Neighboring gene RIKEN cDNA 4930480G23 gene Neighboring gene RIKEN cDNA 4930598A11 gene Neighboring gene gamma-glutamyl hydrolase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipid transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lipid transfer activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylinositol-3,4-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables vitamin E binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables vitamin E binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables vitamin E binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables vitamin E binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables vitamin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryonic placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intermembrane lipid transfer IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular pH reduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of establishment of blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of amyloid-beta clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to pH ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vitamin E metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within vitamin E metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vitamin E metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vitamin E metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vitamin transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in vitamin transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    alpha-tocopherol transfer protein
    Names
    alpha TTP

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317723.1NP_001304652.1  alpha-tocopherol transfer protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' terminal exon, resulting in a novel 5' UTR, and the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared isoform 1.
      Source sequence(s)
      AL732527
      Consensus CDS
      CCDS84707.1
      UniProtKB/TrEMBL
      A8Y5N9
      Related
      ENSMUSP00000113966.2, ENSMUST00000121491.8
      Conserved Domains (1) summary
      pfam00650
      Location:30179
      CRAL_TRIO; CRAL/TRIO domain
    2. NM_015767.4NP_056582.1  alpha-tocopherol transfer protein isoform 1

      See identical proteins and their annotated locations for NP_056582.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK004882, AK050374, AL732527, AV026942, BY072913
      Consensus CDS
      CCDS17995.1
      UniProtKB/Swiss-Prot
      Q8BWP5
      UniProtKB/TrEMBL
      Q499J3
      Related
      ENSMUSP00000095845.2, ENSMUST00000098244.2
      Conserved Domains (2) summary
      smart01100
      Location:2573
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      pfam00650
      Location:99248
      CRAL_TRIO; CRAL/TRIO domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      20007867..20030822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320306.3XP_017175795.1  alpha-tocopherol transfer protein isoform X2

      UniProtKB/TrEMBL
      A8Y5N9
      Conserved Domains (1) summary
      pfam00650
      Location:30179
      CRAL_TRIO; CRAL/TRIO domain
    2. XM_036164225.1XP_036020118.1  alpha-tocopherol transfer protein isoform X1

      Conserved Domains (1) summary
      pfam00650
      Location:68217
      CRAL_TRIO; CRAL/TRIO domain
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