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    Pde3a phosphodiesterase 3A, cGMP inhibited [ Mus musculus (house mouse) ]

    Gene ID: 54611, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Pde3aprovided by MGI
    Official Full Name
    phosphodiesterase 3A, cGMP inhibitedprovided by MGI
    Primary source
    MGI:MGI:1860764
    See related
    Ensembl:ENSMUSG00000041741 AllianceGenome:MGI:1860764
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A930022O17Rik
    Summary
    Enables 3',5'-cyclic-AMP phosphodiesterase activity. Acts upstream of or within several processes, including oocyte maturation; positive regulation of oocyte development; and regulation of meiotic nuclear division. Located in cytosol and membrane. Is expressed in several structures, including alimentary system; central nervous system; cranium; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in hypertension and brachydactyly syndrome. Orthologous to human PDE3A (phosphodiesterase 3A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 3.5), heart adult (RPKM 3.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pde3a in Genome Data Viewer
    Location:
    6 G2; 6 71.87 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (141194995..141452588)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (141249269..141506862)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30215 Neighboring gene ribosomal protein L38, pseudogene 2 Neighboring gene STARR-positive B cell enhancer mm9_chr6:140765370-140765671 Neighboring gene STARR-seq mESC enhancer starr_17681 Neighboring gene STARR-seq mESC enhancer starr_17683 Neighboring gene STARR-seq mESC enhancer starr_17684 Neighboring gene predicted gene, 30524 Neighboring gene ribosomal protein L11 pseudogene Neighboring gene predicted gene 28523 Neighboring gene STARR-seq mESC enhancer starr_17687 Neighboring gene STARR-seq mESC enhancer starr_17688 Neighboring gene STARR-seq mESC enhancer starr_17689 Neighboring gene STARR-seq mESC enhancer starr_17690 Neighboring gene predicted gene 10400 Neighboring gene STARR-seq mESC enhancer starr_17691 Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene solute carrier organic anion transporter family, member 1c1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibition of Phosphodiesterase 3A by Cilostazol Dampens Proinflammatory Platelet Functions. Coenen DM, et al. Cells, 2021 Aug 5. PMID 34440764, Free PMC Article
    2. Phosphodiesterase 3A expression and activity in the murine vasculature is influenced by NO-sensitive guanylyl cyclase. Dünnes S, et al. Pflugers Arch, 2018 Apr. PMID 29294149
    3. Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury. Oikawa M, et al. J Mol Cell Cardiol, 2013 Nov. PMID 23988739, Free PMC Article
    4. Role of PDE3A in regulation of cell cycle progression in mouse vascular smooth muscle cells and oocytes: implications in cardiovascular diseases and infertility. Begum N, et al. Curr Opin Pharmacol, 2011 Dec. PMID 22051884, Free PMC Article
    5. Cyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility. Masciarelli S, et al. J Clin Invest, 2004 Jul. PMID 15254586, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure.
      Title: Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure.
    2. High PDE3A expression is associated with adverse cardiac remodeling.
      Title: Phosphodiesterase type 3A (PDE3A), but not type 3B (PDE3B), contributes to the adverse cardiac remodeling induced by pressure overload.
    3. Study demonstrated the presence of PDE3 protein and mRNA in human and murine airway tissues and concluded that PDE3A or PDE3B deficiency or pharmacological inhibition of PDE3 may alleviate the symptoms of allergic airway inflammation in a house dust mite-driven allergic airway inflammation mouse model.
      Title: A pathophysiological role of PDE3 in allergic airway inflammation.
    4. NO-GC modulates PDE3A expression.
      Title: Phosphodiesterase 3A expression and activity in the murine vasculature is influenced by NO-sensitive guanylyl cyclase.
    5. Data show that phosphodiesterase 3A (PDE3A) was expressed throughout interstitial cells of Cajal (ICC) development and that ICC density was halved in PDE3A-deficient mice.
      Title: Phosphodiesterase 3A: a new player in development of interstitial cells of Cajal and a prospective target in gastrointestinal stromal tumors (GIST).
    6. PDE3A is a low-affinity and high-velocity enzyme for hydrolysis of cUMP in cardiac myocytes.
      Title: cUMP hydrolysis by PDE3A.
    7. These together indicate that PDE3A1 negatively regulates beta-AR signaling and protects against I/R injury by inhibiting cardiomyocyte apoptosis.
      Title: Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury.
    8. PDE3A is the primary isozyme modulating basal myocardial contractility and sarcoplasmic reticulum divalent calcium ion (Ca2+) content.
      Title: Phosphodiesterase type 3A regulates basal myocardial contractility through interacting with sarcoplasmic reticulum calcium ATPase type 2a signaling complexes in mouse heart.
    9. Discussion of role of PDE3A, not PDE3B, in cell cycle progression in vascular smooth muscle and oocytes via regulation of cAMP levels. Is inhibition of PDE3A a possible target for treatment of cardiovascular diseases or female infertility? [REVIEW]
      Title: Role of PDE3A in regulation of cell cycle progression in mouse vascular smooth muscle cells and oocytes: implications in cardiovascular diseases and infertility.
    10. PDE3A regulates VSMC growth via two complementary pathways
      Title: Phosphodiesterase 3A (PDE3A) deletion suppresses proliferation of cultured murine vascular smooth muscle cells (VSMCs) via inhibition of mitogen-activated protein kinase (MAPK) signaling and alterations in critical cell cycle regulatory proteins.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cGMP-inhibited cyclic-nucleotide phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables estrogen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear estrogen receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cGMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to cGMP ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of vascular permeability ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of oocyte development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within oocyte maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of oocyte development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of vascular permeability ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of meiotic nuclear division IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
    Names
    CGI-PDE A
    cGMP-inhibited 3',5'-cyclic phosphodiesterase A
    cGMP-inhibited phosphodiesterase
    cyclic GMP-inhibited phosphodiesterase A
    NP_061249.1
    XP_006507042.1
    XP_011239897.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018779.2 → NP_061249.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

      See identical proteins and their annotated locations for NP_061249.1

      Status: VALIDATED

      Source sequence(s)
      AC155835, AF099187
      Consensus CDS
      CCDS20676.1
      UniProtKB/Swiss-Prot
      Q9Z0X4
      UniProtKB/TrEMBL
      B2RR84
      Related
      ENSMUSP00000038749.8, ENSMUST00000043259.10
      Conserved Domains (1) summary
      pfam00233
      Location:751 → 1012
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      141194995..141452588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506979.5 → XP_006507042.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X2

      Conserved Domains (1) summary
      pfam00233
      Location:451 → 712
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. XM_011241595.4 → XP_011239897.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X1

      Conserved Domains (1) summary
      pfam00233
      Location:456 → 717
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0X4.1 GenPept UniProtKB/Swiss-Prot:Q9Z0X4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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