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    Pde3a phosphodiesterase 3A, cGMP inhibited [ Mus musculus (house mouse) ]

    Gene ID: 54611, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pde3aprovided by MGI
    Official Full Name
    phosphodiesterase 3A, cGMP inhibitedprovided by MGI
    Primary source
    MGI:MGI:1860764
    See related
    Ensembl:ENSMUSG00000041741
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C87899; A930022O17Rik
    Expression
    Broad expression in lung adult (RPKM 3.5), heart adult (RPKM 3.3) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pde3a in Genome Data Viewer
    Location:
    6; 6 G2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (141194995..141452588)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (141249269..141506862)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (141197790..141447872)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30215 Neighboring gene ribosomal protein L38, pseudogene 2 Neighboring gene predicted gene, 30524 Neighboring gene ribosomal protein L11 pseudogene Neighboring gene predicted gene 28523 Neighboring gene predicted gene 10400 Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene solute carrier organic anion transporter family, member 1c1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cGMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cGMP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular permeability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oocyte maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within oocyte maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of oocyte development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of oocyte development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of vascular permeability ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of meiotic nuclear division IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to drug IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cGMP-inhibited 3',5'-cyclic phosphodiesterase A
    Names
    CGI-PDE A
    cGMP-inhibited phosphodiesterase
    cyclic GMP-inhibited phosphodiesterase A
    NP_061249.1
    XP_006507042.1
    XP_011239897.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018779.2NP_061249.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase A

      See identical proteins and their annotated locations for NP_061249.1

      Status: VALIDATED

      Source sequence(s)
      AC155835, AF099187
      Consensus CDS
      CCDS20676.1
      UniProtKB/Swiss-Prot
      Q9Z0X4
      UniProtKB/TrEMBL
      B2RR84
      Related
      ENSMUSP00000038749.8, ENSMUST00000043259.10
      Conserved Domains (1) summary
      pfam00233
      Location:7511012
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      141194995..141452588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506979.5XP_006507042.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X2

      Conserved Domains (1) summary
      pfam00233
      Location:451712
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    2. XM_011241595.4XP_011239897.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1

      Conserved Domains (1) summary
      pfam00233
      Location:456717
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
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