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    Mgst1 microsomal glutathione S-transferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 56615, updated on 6-May-2021

    Summary

    Official Symbol
    Mgst1provided by MGI
    Official Full Name
    microsomal glutathione S-transferase 1provided by MGI
    Primary source
    MGI:MGI:1913850
    See related
    Ensembl:ENSMUSG00000008540
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gst; 1500002K10Rik
    Expression
    Biased expression in liver adult (RPKM 1165.6), liver E18 (RPKM 396.4) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mgst1 in Genome Data Viewer
    Location:
    6; 6 G1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (138117525..138133753)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (138140527..138156755)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (138089058..138105273)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38552 Neighboring gene solute carrier family 15, member 5 Neighboring gene predicted gene, 30213 Neighboring gene RIKEN cDNA A830011K09 gene Neighboring gene LIM domain only 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glutathione binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    microsomal glutathione S-transferase 1
    Names
    microsomal GST-1
    microsomal GST-I
    NP_001334418.1
    NP_001348236.1
    NP_001348237.1
    NP_001348238.1
    NP_064330.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347489.2NP_001334418.1  microsomal glutathione S-transferase 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. These differences result in translation from an alternate start codon. The encoded isoform (2) has a longer N-terminus, compared to isoform 1.
      Source sequence(s)
      AC121849, AC131766
      Consensus CDS
      CCDS85177.1
      UniProtKB/TrEMBL
      E9QJW0
      Related
      ENSMUSP00000112923.2, ENSMUST00000118091.8
    2. NM_001361307.1NP_001348236.1  microsomal glutathione S-transferase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121849, AC131766
      Consensus CDS
      CCDS90131.1
      Related
      ENSMUSP00000112646.2, ENSMUST00000120939.8
    3. NM_001361308.1NP_001348237.1  microsomal glutathione S-transferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121849, AC131766
      Consensus CDS
      CCDS20668.1
      Related
      ENSMUSP00000113257.2, ENSMUST00000120302.8
      Conserved Domains (1) summary
      pfam01124
      Location:19150
      MAPEG; MAPEG family
    4. NM_001361309.1NP_001348238.1  microsomal glutathione S-transferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121849, AC131766
      Consensus CDS
      CCDS20668.1
      Related
      ENSMUSP00000113859.2, ENSMUST00000120230.8
      Conserved Domains (1) summary
      pfam01124
      Location:19150
      MAPEG; MAPEG family
    5. NM_019946.5NP_064330.2  microsomal glutathione S-transferase 1 isoform 1

      See identical proteins and their annotated locations for NP_064330.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (1).
      Source sequence(s)
      AC121849, AC131766, AK005122
      Consensus CDS
      CCDS20668.1
      UniProtKB/Swiss-Prot
      Q91VS7
      UniProtKB/TrEMBL
      Q53ZD4
      Related
      ENSMUSP00000008684.5, ENSMUST00000008684.11
      Conserved Domains (1) summary
      pfam01124
      Location:19150
      MAPEG; MAPEG family

    RNA

    1. NR_154597.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121849, AC131766
    2. NR_154598.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121849, AC131766
      Related
      ENSMUST00000140932.2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      138117525..138133753
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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