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    Myh2 myosin, heavy polypeptide 2, skeletal muscle, adult [ Mus musculus (house mouse) ]

    Gene ID: 17882, updated on 20-Jul-2021

    Summary

    Official Symbol
    Myh2provided by MGI
    Official Full Name
    myosin, heavy polypeptide 2, skeletal muscle, adultprovided by MGI
    Primary source
    MGI:MGI:1339710
    See related
    Ensembl:ENSMUSG00000033196
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MHC2; MHC2A; MyHC-; Myh2a; Myhs-; Myhsf; Myhs-f; Myhsf1; Myhs-f1; MyHC-IIa
    Expression
    Biased expression in mammary gland adult (RPKM 15.2), kidney adult (RPKM 2.7) and 3 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Myh2 in Genome Data Viewer
    Location:
    11 B3; 11 40.59 cM
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (67061853..67088343)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67171027..67197517)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (66984529..67011019)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31285 Neighboring gene predicted gene, 53683 Neighboring gene myosin, heavy polypeptide 1, skeletal muscle, adult Neighboring gene myosin heavy chain gene antisense RNA Neighboring gene myosin, heavy polypeptide 4, skeletal muscle

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in A band IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    part_of muscle myosin complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in myofibril IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in myofibril ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    myosin-2
    Names
    myosin heavy chain 2A
    skeletal muscle myosin heavy chain II-a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039545.2NP_001034634.2  myosin-2

      See identical proteins and their annotated locations for NP_001034634.2

      Status: VALIDATED

      Source sequence(s)
      AL596129
      Consensus CDS
      CCDS24854.2
      UniProtKB/TrEMBL
      G3UW82
      Related
      ENSMUSP00000129544.2, ENSMUST00000170159.8
      Conserved Domains (7) summary
      cl22853
      Location:100773
      Motor_domain; Myosin and Kinesin motor domain
      pfam00063
      Location:88773
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:8531930
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3673
      Myosin_N; Myosin N-terminal SH3-like domain
      cl00459
      Location:13021414
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl19219
      Location:16731770
      DUF342; Protein of unknown function (DUF342)
      cl23720
      Location:9681101
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      67061853..67088343
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_144961.1: Suppressed sequence

      Description
      NM_144961.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
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