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    Rgl1 ral guanine nucleotide dissociation stimulator,-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 19731, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rgl1provided by MGI
    Official Full Name
    ral guanine nucleotide dissociation stimulator,-like 1provided by MGI
    Primary source
    MGI:MGI:107484
    See related
    Ensembl:ENSMUSG00000026482
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    R; Rgl; mKIAA0959
    Summary
    This gene encodes a member of the Ras-like (Ral) -selective guanine nucleotide exchange factor (RalGEF) family of small GTPase activators which function both as downstream effectors of activated Ras GTPase and as regulators of certain Ral GTPases in the RalGEF - Ral GTPase signaling pathway. The encoded protein, like other RalGEFs, has an N-terminal ras exchanger motif domain, a catalytic CDC25 homology domain, and a C-terminal ras binding domain that stimulates guanine nucleotide exchange when bound to a Ral GTPase. RalGEF family members bridge the Ras and Ral signaling pathways and are thought to play a role in oncogenic transformation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
    Expression
    Ubiquitous expression in kidney adult (RPKM 21.8), placenta adult (RPKM 12.6) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rgl1 in Genome Data Viewer
    Location:
    1; 1 G2- G3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (152392513..152642089, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (152516762..152766308, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (154364660..154472241, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 15 Neighboring gene collagen beta(1-O)galactosyltransferase 2 Neighboring gene basic transcription factor 3, pseudogene 14 Neighboring gene predicted gene, 51749 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) Neighboring gene actin related protein 2/3 complex, subunit 5 Neighboring gene neutrophil cytosolic factor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0959

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ral guanine nucleotide dissociation stimulator-like 1
    Names
    ralGDS-like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346117.1NP_001333046.1  ral guanine nucleotide dissociation stimulator-like 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC118051, AC123613, AC123732, AK169109, BY245021, CN693385
      Consensus CDS
      CCDS87891.1
      UniProtKB/Swiss-Prot
      Q60695
      UniProtKB/TrEMBL
      E9Q8M9
    2. NM_001346118.1NP_001333047.1  ral guanine nucleotide dissociation stimulator-like 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC118051, AC123613, AC123732, AK169109, BY245021, CN693385
      Consensus CDS
      CCDS87891.1
      UniProtKB/Swiss-Prot
      Q60695
      UniProtKB/TrEMBL
      E9Q8M9
      Related
      ENSMUSP00000107490.2, ENSMUST00000111859.8
    3. NM_001346119.1NP_001333048.1  ral guanine nucleotide dissociation stimulator-like 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC118051, AC123613, AC123732, AK169109, BY245021, CN693385
      Consensus CDS
      CCDS87890.1
      UniProtKB/Swiss-Prot
      Q60695
      UniProtKB/TrEMBL
      E9Q8N0
      Related
      ENSMUSP00000107488.2, ENSMUST00000111857.3
      Conserved Domains (3) summary
      smart00229
      Location:63194
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:226495
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd17210
      Location:645731
      RA_RGL; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins
    4. NM_016846.4NP_058542.2  ral guanine nucleotide dissociation stimulator-like 1 isoform 3

      See identical proteins and their annotated locations for NP_058542.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate start codon and result in an isoform (3) with a shorter and distinct N-terminus, compared to isoform 1
      Source sequence(s)
      AC118051, AC123732, AK169109
      Consensus CDS
      CCDS15365.1
      UniProtKB/Swiss-Prot
      Q60695
      Related
      ENSMUSP00000027760.8, ENSMUST00000027760.14
      Conserved Domains (3) summary
      cd00153
      Location:648733
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00229
      Location:65196
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:228497
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      152392513..152642089 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162813.1XP_036018706.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X1

      Conserved Domains (3) summary
      smart00229
      Location:63194
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:226495
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd17210
      Location:645731
      RA_RGL; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins
    2. XM_006529268.5XP_006529331.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X3

      Conserved Domains (3) summary
      smart00229
      Location:20151
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:183452
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd17210
      Location:602688
      RA_RGL; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins
    3. XM_006529267.5XP_006529330.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X2

      Conserved Domains (2) summary
      cd00155
      Location:51320
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd17210
      Location:470556
      RA_RGL; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins
    4. XM_006529266.5XP_006529329.1  ral guanine nucleotide dissociation stimulator-like 1 isoform X1

      UniProtKB/TrEMBL
      E9Q8N0
      Conserved Domains (3) summary
      smart00229
      Location:63194
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:226495
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd17210
      Location:645731
      RA_RGL; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) and similar proteins
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