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    Defa39 defensin, alpha, 39 [ Mus musculus (house mouse) ]

    Gene ID: 382000, updated on 26-Jun-2021

    Summary

    Official Symbol
    Defa39provided by MGI
    Official Full Name
    defensin, alpha, 39provided by MGI
    Primary source
    MGI:MGI:3611585
    See related
    Ensembl:ENSMUSG00000058618
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CRS1C; AY76118; CRS1C-3; CRS1C-6
    Expression
    Biased expression in large intestine adult (RPKM 462.8), small intestine adult (RPKM 265.0) and 1 other tissue See more
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    Genomic context

    See Defa39 in Genome Data Viewer
    Location:
    8; 8 A2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22192540..22193663, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (21702524..21703647, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (22812996..22814119, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene defensin, alpha, 34 Neighboring gene defensin, alpha, pseudogene 1 Neighboring gene predicted gene, 22447 Neighboring gene zinc finger, MYM-type 5 pseudogene Neighboring gene defensin, alpha, pseudogene 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in antibacterial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in defense response to Gram-negative bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in innate immune response in mucosa IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in membrane disruption in other organism IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in azurophil granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    Alpha-defensin-related sequence 1-like
    Names
    novel defensin-related cryptidin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007582.3NP_001007583.1  Alpha-defensin-related sequence 1-like precursor

      See identical proteins and their annotated locations for NP_001007583.1

      Status: VALIDATED

      Source sequence(s)
      AC134533, AK008498
      Consensus CDS
      CCDS22156.1
      UniProtKB/TrEMBL
      Q9D848
      Related
      ENSMUSP00000071783.7, ENSMUST00000071886.7
      Conserved Domains (1) summary
      pfam00879
      Location:1551
      Defensin_propep; Defensin propeptide

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      22192540..22193663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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