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    Msr1 macrophage scavenger receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 20288, updated on 26-Jun-2021

    Summary

    Official Symbol
    Msr1provided by MGI
    Official Full Name
    macrophage scavenger receptor 1provided by MGI
    Primary source
    MGI:MGI:98257
    See related
    Ensembl:ENSMUSG00000025044
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S; MR; MS; Sc; MSR; Scvr; MRS-A; MSR-A; SR-AI; SR-AII; Scara1
    Expression
    Broad expression in liver E18 (RPKM 1.9), liver E14 (RPKM 1.1) and 18 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Msr1 in Genome Data Viewer
    Location:
    8 A4; 8 23.89 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (39996284..40095790, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (39543232..39642750, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (40667054..40728032, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6213 Neighboring gene voltage-dependent anion channel 3 pseudogene Neighboring gene copine VIII pseudogene Neighboring gene H/ACA ribonucleoprotein complex subunit 3 pseudogene Neighboring gene predicted gene, 36741

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amyloid-beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables amyloid-beta binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables cargo receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables low-density lipoprotein particle binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables low-density lipoprotein particle binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of low-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    macrophage scavenger receptor types I and II
    Names
    SR-A
    macrophage acetylated LDL receptor I and II
    scavenger receptor type A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113326.1NP_001106797.1  macrophage scavenger receptor types I and II isoform b

      See identical proteins and their annotated locations for NP_001106797.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes alternate exons in the 5' coding region, compared to variant 1. The resulting protein (isoform b) has a distinct C-terminus and is longer than isoform a.
      Source sequence(s)
      AF203781, AK150518
      Consensus CDS
      CCDS52542.1
      UniProtKB/Swiss-Prot
      P30204
      UniProtKB/TrEMBL
      Q8CED7
      Related
      ENSMUSP00000026021.7, ENSMUST00000026021.14
      Conserved Domains (4) summary
      pfam01391
      Location:277338
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:357457
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:362457
      SRCR; Scavenger receptor cysteine-rich domain
      pfam03523
      Location:125173
      Macscav_rec; Macrophage scavenger receptor
    2. NM_031195.2NP_112472.2  macrophage scavenger receptor types I and II isoform a

      See identical proteins and their annotated locations for NP_112472.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (a).
      Source sequence(s)
      AC111028, AK151855, AK155589
      Consensus CDS
      CCDS52543.1
      UniProtKB/TrEMBL
      Q8CED7
      Related
      ENSMUSP00000132535.2, ENSMUST00000170091.3
      Conserved Domains (3) summary
      pfam01391
      Location:277338
      Collagen; Collagen triple helix repeat (20 copies)
      COG0840
      Location:118275
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      pfam03523
      Location:125173
      Macscav_rec; Macrophage scavenger receptor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      39996284..40095790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509311.4XP_006509374.1  macrophage scavenger receptor types I and II isoform X1

      Conserved Domains (4) summary
      pfam01391
      Location:306367
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:386443
      SR; Scavenger receptor Cys-rich
      COG0840
      Location:147304
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      pfam03523
      Location:154202
      Macscav_rec; Macrophage scavenger receptor
    2. XM_006509312.4XP_006509375.1  macrophage scavenger receptor types I and II isoform X2

      Conserved Domains (4) summary
      pfam01391
      Location:273334
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:353453
      SR; Scavenger receptor Cys-rich
      COG0840
      Location:114271
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      pfam03523
      Location:121169
      Macscav_rec; Macrophage scavenger receptor
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