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    Slc47a1 solute carrier family 47, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 67473, updated on 23-Jun-2021

    Summary

    Official Symbol
    Slc47a1provided by MGI
    Official Full Name
    solute carrier family 47, member 1provided by MGI
    Primary source
    MGI:MGI:1914723
    See related
    Ensembl:ENSMUSG00000010122
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MATE; MATE1; mMATE; mMATE1; AI036982; 1300013J15Rik
    Expression
    Biased expression in kidney adult (RPKM 97.2), liver adult (RPKM 32.0) and 3 other tissues See more
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    Genomic context

    See Slc47a1 in Genome Data Viewer
    Location:
    11; 11 B2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61234226..61269668, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61343400..61378842, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (61156902..61191577, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase family 3, subfamily A2 Neighboring gene solute carrier family 47, member 2 Neighboring gene predicted gene, 25929 Neighboring gene POU domain, class 5, transcription factor 1, related sequence 12 Neighboring gene predicted gene, 42081 Neighboring gene nuclear encoded tRNA trytophan 5 (anticodon CCA)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    • Homologs of the Slc47a1 gene: The Slc47a1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
    • Orthologs

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-arginine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables amide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables xenobiotic transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-arginine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amino acid import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cation transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cation transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in organic cation transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in organic cation transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    multidrug and toxin extrusion protein 1
    Names
    MATE-1
    mMATE-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026183.5NP_080459.2  multidrug and toxin extrusion protein 1

      See identical proteins and their annotated locations for NP_080459.2

      Status: VALIDATED

      Source sequence(s)
      AK009038, BB556514, BB661673, BY006577
      Consensus CDS
      CCDS24811.2
      UniProtKB/Swiss-Prot
      Q8K0H1
      Related
      ENSMUSP00000010267.4, ENSMUST00000010267.10
      Conserved Domains (2) summary
      COG0534
      Location:26464
      NorM; Na+-driven multidrug efflux pump [Defense mechanisms]
      cd13132
      Location:34468
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      61234226..61269668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249188.3XP_011247490.1  multidrug and toxin extrusion protein 1 isoform X2

      Conserved Domains (1) summary
      cd13132
      Location:1418
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
    2. XM_006533993.2XP_006534056.1  multidrug and toxin extrusion protein 1 isoform X1

      Conserved Domains (1) summary
      cd13132
      Location:70492
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
    3. XM_036156909.1XP_036012802.1  multidrug and toxin extrusion protein 1 isoform X4

      Conserved Domains (1) summary
      cd13132
      Location:22308
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
    4. XM_036156910.1XP_036012803.1  multidrug and toxin extrusion protein 1 isoform X4

      Conserved Domains (1) summary
      cd13132
      Location:22308
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
    5. XM_011249189.4XP_011247491.1  multidrug and toxin extrusion protein 1 isoform X3

      See identical proteins and their annotated locations for XP_011247491.1

      UniProtKB/Swiss-Prot
      Q8K0H1
      Conserved Domains (1) summary
      cd13132
      Location:40326
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
    6. XM_006533995.4XP_006534058.1  multidrug and toxin extrusion protein 1 isoform X5

      Conserved Domains (1) summary
      cd13132
      Location:1280
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

    RNA

    1. XR_003949493.1 RNA Sequence

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