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    Alg11 asparagine-linked glycosylation 11 (alpha-1,2-mannosyltransferase) [ Mus musculus (house mouse) ]

    Gene ID: 207958, updated on 23-Jun-2021

    Summary

    Official Symbol
    Alg11provided by MGI
    Official Full Name
    asparagine-linked glycosylation 11 (alpha-1,2-mannosyltransferase)provided by MGI
    Primary source
    MGI:MGI:2142632
    See related
    Ensembl:ENSMUSG00000063362
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI849156; AW492253; Mmat-4(5); B230397C21
    Expression
    Ubiquitous expression in placenta adult (RPKM 5.0), bladder adult (RPKM 4.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Alg11 in Genome Data Viewer
    Location:
    8; 8 A2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22550731..22561643)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22060721..22071627)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (23171192..23178761)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 70 Neighboring gene ATPase, Cu++ transporting, beta polypeptide Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 5 Neighboring gene small nucleolar RNA U13 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in oligosaccharide-lipid intermediate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
    Names
    asparagine-linked glycosylation 11 homolog (yeast, alpha-1,2-mannosyltransferase)
    asparagine-linked glycosylation protein 11 homolog
    defective mannosyltransferase IV(V)
    glycolipid 2-alpha-mannosyltransferase
    mannosyltransferase IV(V)
    NP_001230090.1
    NP_898965.1
    XP_006509108.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243161.1NP_001230090.1  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase isoform 1

      See identical proteins and their annotated locations for NP_001230090.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK157746, BC061469
      Consensus CDS
      CCDS57613.1
      UniProtKB/Swiss-Prot
      Q3TZM9
      UniProtKB/TrEMBL
      A0A077K846
      Related
      ENSMUSP00000072382.7, ENSMUST00000072572.13
      Conserved Domains (2) summary
      cd03806
      Location:64480
      GT1_ALG11_like; This family is most closely related to the GT1 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown ...
      PLN02949
      Location:64492
      PLN02949; transferase, transferring glycosyl groups
    2. NM_183142.4NP_898965.1  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase isoform 2

      See identical proteins and their annotated locations for NP_898965.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK046475, AK157746, BC061469
      Consensus CDS
      CCDS40292.1
      UniProtKB/Swiss-Prot
      Q3TZM9
      Related
      ENSMUSP00000106365.3, ENSMUST00000110737.3
      Conserved Domains (2) summary
      cd03806
      Location:64438
      GT1_ALG11_like; This family is most closely related to the GT1 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown ...
      PLN02949
      Location:64450
      PLN02949; transferase, transferring glycosyl groups

    RNA

    1. NR_040650.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site that introduces a premature stop codon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK157746, BC061469

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      22550731..22561643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509045.3XP_006509108.1  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase isoform X1

      Conserved Domains (1) summary
      cd03806
      Location:39455
      GT4_ALG11-like; alpha-1,2-mannosyltransferase ALG11 and similar proteins
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