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    E130308A19Rik RIKEN cDNA E130308A19 gene [ Mus musculus (house mouse) ]

    Gene ID: 230259, updated on 5-Mar-2024

    Summary

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    Official Symbol
    E130308A19Rikprovided by MGI
    Official Full Name
    RIKEN cDNA E130308A19 geneprovided by MGI
    Primary source
    MGI:MGI:2442164
    See related
    Ensembl:ENSMUSG00000045071 AllianceGenome:MGI:2442164
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Is expressed in neural retina. Orthologous to human KIAA1958 (KIAA1958). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 1.9), whole brain E14.5 (RPKM 1.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 B3; 4 32.73 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (59626116..59757649)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (59626116..59757649)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene polypyrimidine tract binding protein 3 Neighboring gene STARR-seq mESC enhancer starr_10379 Neighboring gene STARR-positive B cell enhancer ABC_E4631 Neighboring gene STARR-positive B cell enhancer ABC_E6183 Neighboring gene STARR-positive B cell enhancer ABC_E835 Neighboring gene STARR-seq mESC enhancer starr_10381 Neighboring gene hydroxysteroid dehydrogenase like 2 Neighboring gene predicted gene, 54283 Neighboring gene STARR-seq mESC enhancer starr_10382 Neighboring gene STARR-positive B cell enhancer ABC_E421 Neighboring gene STARR-seq mESC enhancer starr_10383 Neighboring gene STARR-positive B cell enhancer ABC_E7970 Neighboring gene STARR-positive B cell enhancer ABC_E3493 Neighboring gene INTS3 and NABP interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E6184 Neighboring gene STARR-positive B cell enhancer ABC_E9590 Neighboring gene STARR-positive B cell enhancer ABC_E10237 Neighboring gene sorting nexin family member 30 Neighboring gene sorting nexin 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC47072

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein KIAA1958 homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015681.2 → NP_001015681.1  uncharacterized protein KIAA1958 homolog isoform 2

      See identical proteins and their annotated locations for NP_001015681.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longer isoform (2).
      Source sequence(s)
      AK047478, AK081604
      Consensus CDS
      CCDS18223.1
      UniProtKB/Swiss-Prot
      B1AX79, Q8BN62, Q8C4P0, Q8K1X8
      UniProtKB/TrEMBL
      Q0P6E2
      Related
      ENSMUSP00000065702.5, ENSMUST00000070150.11
      Conserved Domains (1) summary
      pfam12012
      Location:532 → 686
      DUF3504; Domain of unknown function (DUF3504)

    2. NM_153158.5 → NP_694798.1  uncharacterized protein KIAA1958 homolog isoform 1

      See identical proteins and their annotated locations for NP_694798.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) contains an alternate 3' terminal exon compared to variant 2. It encodes isoform 1, which is shorter and has a distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      AK047478, AK047601, AL806512
      Consensus CDS
      CCDS18224.1
      UniProtKB/Swiss-Prot
      Q8C4P0
      Related
      ENSMUSP00000062493.7, ENSMUST00000052420.7
      Conserved Domains (2) summary
      COG3456
      Location:255 → 411
      COG3456; Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport]
      cl00213
      Location:523 → 669
      DNA_BRE_C; DNA breaking-rejoining enzymes, C-terminal catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      59626116..59757649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537855.4 → XP_006537918.1  uncharacterized protein KIAA1958 homolog isoform X1

      See identical proteins and their annotated locations for XP_006537918.1

      Conserved Domains (2) summary
      pfam12012
      Location:577 → 725
      DUF3504; Domain of unknown function (DUF3504)
      pfam17823
      Location:226 → 386
      DUF5585; Family of unknown function (DUF5585)

    2. XM_006537861.3 → XP_006537924.1  uncharacterized protein KIAA1958 homolog isoform X2

      See identical proteins and their annotated locations for XP_006537924.1

      UniProtKB/Swiss-Prot
      Q8C4P0
      Conserved Domains (2) summary
      COG3456
      Location:255 → 411
      COG3456; Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport]
      cl00213
      Location:523 → 669
      DNA_BRE_C; DNA breaking-rejoining enzymes, C-terminal catalytic domain

    3. XM_006537864.4 → XP_006537927.1  uncharacterized protein KIAA1958 homolog isoform X3

      Conserved Domains (1) summary
      COG3456
      Location:255 → 387
      COG3456; Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport]

    4. XM_011250008.4 → XP_011248310.1  uncharacterized protein KIAA1958 homolog isoform X1

      See identical proteins and their annotated locations for XP_011248310.1

      Conserved Domains (2) summary
      pfam12012
      Location:577 → 725
      DUF3504; Domain of unknown function (DUF3504)
      pfam17823
      Location:226 → 386
      DUF5585; Family of unknown function (DUF5585)

    5. XM_036163991.1 → XP_036019884.1  uncharacterized protein KIAA1958 homolog isoform X2

      Conserved Domains (2) summary
      COG3456
      Location:255 → 411
      COG3456; Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport]
      cl00213
      Location:523 → 669
      DNA_BRE_C; DNA breaking-rejoining enzymes, C-terminal catalytic domain

    6. XM_006537858.3 → XP_006537921.1  uncharacterized protein KIAA1958 homolog isoform X1

      See identical proteins and their annotated locations for XP_006537921.1

      Conserved Domains (2) summary
      pfam12012
      Location:577 → 725
      DUF3504; Domain of unknown function (DUF3504)
      pfam17823
      Location:226 → 386
      DUF5585; Family of unknown function (DUF5585)

    RNA

    1. XR_004941861.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C4P0.1 GenPept UniProtKB/Swiss-Prot:Q8C4P0

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