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    Ptpro protein tyrosine phosphatase, receptor type, O [ Mus musculus (house mouse) ]

    Gene ID: 19277, updated on 5-Sep-2021

    Summary

    Official Symbol
    Ptproprovided by MGI
    Official Full Name
    protein tyrosine phosphatase, receptor type, Oprovided by MGI
    Primary source
    MGI:MGI:1097152
    See related
    Ensembl:ENSMUSG00000030223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PT; D28; GLE; PTP; PTP-; PTPBK; PTPU2; PTPoc; GLEPP1; PTPROt; PTPphi; Ptpn15; R-PTP-O
    Expression
    Biased expression in frontal lobe adult (RPKM 15.3), CNS E18 (RPKM 13.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ptpro in Genome Data Viewer
    Location:
    6; 6 G1
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (137229189..137441632)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (137252299..137464634)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (137200820..137413155)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RAS-like, estrogen-regulated, growth-inhibitor Neighboring gene predicted gene, 52923 Neighboring gene predicted gene, 38914 Neighboring gene predicted gene, 52924 Neighboring gene epidermal growth factor receptor pathway substrate 8 Neighboring gene predicted gene, 38915

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables Wnt-protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glomerular visceral epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in glomerular visceral epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glomerulus development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of glomerular filtration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-tyrosine dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-tyrosine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of glomerular filtration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of glomerular filtration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synapse organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in slit diaphragm assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    receptor-type tyrosine-protein phosphatase O
    Names
    PTPase U2
    glomerular epithelial protein 1
    protein tyrosine phosphatase U2
    protein tyrosine phosphatase, non-receptor type 15
    receptor protein tyrosine phosphatase RO
    NP_001157873.1
    NP_001157874.1
    NP_001157875.1
    NP_035346.3
    XP_036021846.1
    XP_036021847.1
    XP_036021848.1
    XP_036021849.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164401.1NP_001157873.1  receptor-type tyrosine-protein phosphatase O isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC093120, AC144767, AC163627, AW490226
      Consensus CDS
      CCDS51943.1
      UniProtKB/TrEMBL
      E9Q4I1
      Related
      ENSMUSP00000127112.2, ENSMUST00000167679.8
      Conserved Domains (4) summary
      smart00194
      Location:9191174
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:9471175
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:444536
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:735815
      fn3; Fibronectin type III domain
    2. NM_001164402.1NP_001157874.1  receptor-type tyrosine-protein phosphatase O isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences causes translation initiation at a downstream AUG, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC093120, AC163627, AW490226
      Consensus CDS
      CCDS51944.1
      UniProtKB/TrEMBL
      E9PVJ6
      Related
      ENSMUSP00000131764.2, ENSMUST00000167002.4
      Conserved Domains (2) summary
      smart00194
      Location:126381
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:154382
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    3. NM_001164403.1NP_001157875.1  receptor-type tyrosine-protein phosphatase O isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences causes translation initiation at a downstream AUG, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC093120, AC163627, AW490226
      Consensus CDS
      CCDS85176.1
      UniProtKB/TrEMBL
      A0A0N4SUY2
      Related
      ENSMUSP00000144870.2, ENSMUST00000203914.2
      Conserved Domains (2) summary
      smart00194
      Location:98353
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:126354
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    4. NM_011216.3NP_035346.3  receptor-type tyrosine-protein phosphatase O isoform 1 precursor

      See identical proteins and their annotated locations for NP_035346.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC093120, AC163627, AW490226, BC052743, CB523320
      Consensus CDS
      CCDS20664.1
      UniProtKB/Swiss-Prot
      E9Q612
      Related
      ENSMUSP00000076364.7, ENSMUST00000077115.13
      Conserved Domains (4) summary
      smart00194
      Location:9471202
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:9751203
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:444536
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:735815
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      137229189..137441632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165953.1XP_036021846.1  receptor-type tyrosine-protein phosphatase O isoform X1

      Conserved Domains (3) summary
      cd00063
      Location:479571
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14614
      Location:9961240
      R-PTPc-O; catalytic domain of receptor-type tyrosine-protein phosphatase O
      pfam00041
      Location:770850
      fn3; Fibronectin type III domain
    2. XM_036165954.1XP_036021847.1  receptor-type tyrosine-protein phosphatase O isoform X2

      Conserved Domains (3) summary
      cd00063
      Location:479571
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14614
      Location:9681212
      R-PTPc-O; catalytic domain of receptor-type tyrosine-protein phosphatase O
      pfam00041
      Location:770850
      fn3; Fibronectin type III domain
    3. XM_036165956.1XP_036021849.1  receptor-type tyrosine-protein phosphatase O isoform X4

      Conserved Domains (3) summary
      cd00063
      Location:279371
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14614
      Location:7961040
      R-PTPc-O; catalytic domain of receptor-type tyrosine-protein phosphatase O
      pfam00041
      Location:570650
      fn3; Fibronectin type III domain
    4. XM_036165955.1XP_036021848.1  receptor-type tyrosine-protein phosphatase O isoform X3

      Conserved Domains (3) summary
      cd00063
      Location:443535
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14614
      Location:9601204
      R-PTPc-O; catalytic domain of receptor-type tyrosine-protein phosphatase O
      pfam00041
      Location:734814
      fn3; Fibronectin type III domain
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