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    Tap1 transporter 1, ATP binding cassette subfamily B member [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24811, updated on 8-Jul-2021

    Summary

    Official Symbol
    Tap1provided by RGD
    Official Full Name
    transporter 1, ATP binding cassette subfamily B memberprovided by RGD
    Primary source
    RGD:3817
    See related
    Ensembl:ENSRNOG00000000457
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cim; Tap2; Abcb2
    Summary
    has similarity to multidrug resistant transporters; may transport antigenic peptides across the endoplasmic reticulum membrane in preparation for MHC class I presentation [RGD, Feb 2006]
    Expression
    Biased expression in Thymus (RPKM 337.5), Spleen (RPKM 282.5) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tap1 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    108 current mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4656262..4666634, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3979302..3989669)

    Chromosome 20 - NC_051355.1Genomic Context describing neighboring genes Neighboring gene transporter 2, ATP binding cassette subfamily B member Neighboring gene proteasome 20S subunit beta 8 Neighboring gene proteasome 20S subunit beta 9 Neighboring gene RT1 class II, locus DMb

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC124549

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ABC-type peptide antigen transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ABC-type peptide antigen transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ABC-type peptide antigen transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ABC-type peptide antigen transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables ABC-type peptide transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ADP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables MHC class I protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables MHC class I protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables MHC class I protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MHC class Ib protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables MHC class Ib protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables TAP1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables TAP1 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables TAP2 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables TAP2 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables TAP2 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to peptide antigen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide antigen binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide antigen binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to peptide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tapasin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tapasin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytosol to endoplasmic reticulum transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytosol to endoplasmic reticulum transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within defense response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide antigen transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in peptide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peptide transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptide transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptide transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protection from natural killer cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of MHC class I peptide loading complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of MHC class I peptide loading complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of MHC class I peptide loading complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of TAP complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of TAP complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of TAP complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    antigen peptide transporter 1
    Names
    APT1
    ATP-binding cassette sub-family B member 2
    peptide transporter TAP1
    transporter 1 ABC (ATP binding cassette)
    transporter 1 ATP-binding cassette sub-family B
    transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032055.4NP_114444.2  antigen peptide transporter 1 precursor

      See identical proteins and their annotated locations for NP_114444.2

      Status: VALIDATED

      Source sequence(s)
      BC101854, BX883043, Y10234
      UniProtKB/TrEMBL
      P97561, P97949
      Related
      ENSRNOP00000000529.4, ENSRNOT00000000529.6
      Conserved Domains (3) summary
      TIGR00958
      Location:2717
      3a01208; Conjugate Transporter-2 (CT2) Family protein
      pfam00664
      Location:177435
      ABC_membrane; ABC transporter transmembrane region
      cl21455
      Location:469697
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRatBN7.2 Primary Assembly

    Genomic

    1. NC_051355.1 Reference mRatBN7.2 Primary Assembly

      Range
      4656262..4666634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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