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    Tmem100 transmembrane protein 100 [ Mus musculus (house mouse) ]

    Gene ID: 67888, updated on 5-Jan-2022

    Summary

    Official Symbol
    Tmem100provided by MGI
    Official Full Name
    transmembrane protein 100provided by MGI
    Primary source
    MGI:MGI:1915138
    See related
    Ensembl:ENSMUSG00000069763
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AV011897; 1810057C19Rik
    Summary
    Involved in positive regulation of endothelial cell differentiation; positive regulation of vasculogenesis; and regulation of sensory perception of pain. Acts upstream of or within several processes, including circulatory system development; protein kinase B signaling; and regulation of calcium-mediated signaling. Located in perikaryon; perinuclear region of cytoplasm; and plasma membrane. Is expressed in several structures, including cardiovascular system; eye; genitourinary system; hemolymphoid system gland; and spinal cord. Orthologous to human TMEM100 (transmembrane protein 100). [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Biased expression in lung adult (RPKM 79.8), subcutaneous fat pad adult (RPKM 7.4) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Tmem100 in Genome Data Viewer
    Location:
    11; 11 C
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (89921174..89927334)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (90030348..90036508)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (89891662..89897819)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34677 Neighboring gene phosphatidylcholine transfer protein Neighboring gene predicted gene, 53693 Neighboring gene glutathione S-transferase alpha-4 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within arterial endothelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to BMP stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to BMP stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endocardial cushion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within epithelial to mesenchymal transition involved in endocardial cushion formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026433.2NP_080709.1  transmembrane protein 100

      See identical proteins and their annotated locations for NP_080709.1

      Status: PROVISIONAL

      Source sequence(s)
      AK007878
      Consensus CDS
      CCDS25239.1
      UniProtKB/Swiss-Prot
      Q9CQG9
      Related
      ENSMUSP00000090464.4, ENSMUST00000092788.4
      Conserved Domains (1) summary
      pfam16311
      Location:1133
      TMEM100; Transmembrane protein 100

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      89921174..89927334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534031.2XP_006534094.1  transmembrane protein 100 isoform X1

      See identical proteins and their annotated locations for XP_006534094.1

      UniProtKB/Swiss-Prot
      Q9CQG9
      Conserved Domains (1) summary
      pfam16311
      Location:1133
      TMEM100; Transmembrane protein 100
    2. XM_006534030.5XP_006534093.1  transmembrane protein 100 isoform X1

      See identical proteins and their annotated locations for XP_006534093.1

      UniProtKB/Swiss-Prot
      Q9CQG9
      Conserved Domains (1) summary
      pfam16311
      Location:1133
      TMEM100; Transmembrane protein 100
    3. XM_036156923.1XP_036012816.1  transmembrane protein 100 isoform X1

      Conserved Domains (1) summary
      pfam16311
      Location:1133
      TMEM100; Transmembrane protein 100
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