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    mAcon1 Mitochondrial aconitase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44149, updated on 6-Jul-2021

    Summary

    Official Symbol
    mAcon1provided by FlyBase
    Official Full Name
    Mitochondrial aconitase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0010100
    Locus tag
    Dmel_CG9244
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    acon; Acon; ACON-1; aconitase; AconM; BEST:GH10550; CG9244; Dmel\CG9244; hsp60; i204; i59; l(2)07054; m-acon; m-Acon; M-Acon; mAc; mAcon; mACON
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    Genomic context

    See mAcon1 in Genome Data Viewer
    Location:
    39A7-39A7; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21168570..21173185)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21168570..21173185)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Phospholipase D family member 3 Neighboring gene Nibbler Neighboring gene antisense RNA:CR44910 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : PsiU2-38.40.42 Neighboring gene uncharacterized protein Neighboring gene burgundy

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    • Homologs of the mAcon1 gene: The mAcon1 gene is conserved in human, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.
    • Orthologs

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables aconitate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables aconitate hydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables aconitate hydratase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in tricarboxylic acid cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    mitochondrial aconitase 1
    Names
    ACONITASE
    CG9244-PB
    CG9244-PD
    CG9244-PE
    CG9244-PF
    m-aconitase
    mAcon1-PB
    mAcon1-PD
    mAcon1-PE
    mAcon1-PF
    mitochondrial aconitase
    NP_001097186.2
    NP_001163030.1
    NP_001286119.1
    NP_524708.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21168570..21173185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299190.1NP_001286119.1  mitochondrial aconitase 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286119.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIE8
      Related
      FBpp0312178, FBtr0346587
      Conserved Domains (3) summary
      cd01584
      Location:102513
      AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
      cd01578
      Location:595743
      AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...
      TIGR01340
      Location:52782
      aconitase_mito; aconitate hydratase, mitochondrial
    2. NM_001103716.2NP_001097186.2  mitochondrial aconitase 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097186.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIE8
      Related
      FBpp0310408, FBtr0343871
      Conserved Domains (3) summary
      cd01584
      Location:102513
      AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
      cd01578
      Location:595743
      AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...
      TIGR01340
      Location:52782
      aconitase_mito; aconitate hydratase, mitochondrial
    3. NM_001169559.2NP_001163030.1  mitochondrial aconitase 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163030.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIE8
      Related
      FBpp0289654, FBtr0300425
      Conserved Domains (3) summary
      cd01584
      Location:102513
      AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
      cd01578
      Location:595743
      AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...
      TIGR01340
      Location:52782
      aconitase_mito; aconitate hydratase, mitochondrial
    4. NM_079969.5NP_524708.1  mitochondrial aconitase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524708.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIE8
      Related
      FBpp0081002, FBtr0081473
      Conserved Domains (3) summary
      cd01584
      Location:102513
      AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
      cd01578
      Location:595743
      AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...
      TIGR01340
      Location:52782
      aconitase_mito; aconitate hydratase, mitochondrial
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