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    Aco2 aconitase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79250, updated on 6-May-2021

    Summary

    Official Symbol
    Aco2provided by RGD
    Official Full Name
    aconitase 2provided by RGD
    Primary source
    RGD:621360
    See related
    Ensembl:ENSRNOG00000024128
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Heart (RPKM 5609.7), Muscle (RPKM 4060.0) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Aco2 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    108 current mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (113385677..113428794)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (123102493..123145608)

    Chromosome 7 - NC_051342.1Genomic Context describing neighboring genes Neighboring gene transducer of ERBB2, 2 Neighboring gene PHD finger protein 5A Neighboring gene RNA polymerase III subunit H Neighboring gene uncharacterized LOC102549144 Neighboring gene small nucleolar RNA SNORA44

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3 iron, 4 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 4 iron, 4 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables aconitate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables aconitate hydratase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables aconitate hydratase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables citrate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in citrate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within citrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in isocitrate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in liver development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to isolation stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in tricarboxylic acid cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    aconitate hydratase, mitochondrial
    Names
    aconitase 2, mitochondrial
    citrate hydro-lyase
    mitochondrial aconitase (nuclear aco2 gene)
    NP_077374.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024398.2NP_077374.2  aconitate hydratase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_077374.2

      Status: PROVISIONAL

      Source sequence(s)
      BC061999
      UniProtKB/Swiss-Prot
      Q9ER34
      Related
      ENSRNOP00000029144.3, ENSRNOT00000038612.5
      Conserved Domains (1) summary
      TIGR01340
      Location:45775
      aconitase_mito; aconitate hydratase, mitochondrial

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRatBN7.2 Primary Assembly

    Genomic

    1. NC_051342.1 Reference mRatBN7.2 Primary Assembly

      Range
      113385677..113428794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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