Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Myh10 myosin heavy chain 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79433, updated on 30-Sep-2021

    Summary

    Official Symbol
    Myh10provided by RGD
    Official Full Name
    myosin heavy chain 10provided by RGD
    Primary source
    RGD:71000
    See related
    EnsemblRapid:ENSRNOG00000002886
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MCH-B; SMemb; NMMHC-B
    Summary
    nonmuscle myosin II heavy chain: produces motor activity with actin filaments; isoform B2 may play a role in neuronal cell motility [RGD, Feb 2006]
    Expression
    Biased expression in Lung (RPKM 265.9), Brain (RPKM 225.3) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Myh10 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (53393901..53525174)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (55274910..55406738)

    Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 42 Neighboring gene similar to microfibrillar-associated protein 1 Neighboring gene 60S ribosomal protein L30-like Neighboring gene nudE neurodevelopment protein 1-like 1 Neighboring gene peroxiredoxin-6-like Neighboring gene ring finger protein 222

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA stem-loop binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA stem-loop binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA 5'-UTR binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA 5'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microfilament motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to microfilament motor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables microfilament motor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament bundle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin filament bundle distribution IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin filament-based movement IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within actin filament-based movement ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actomyosin structure organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actomyosin structure organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within adult heart development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within aorta development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in brain development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within brain development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac myofibril assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac septum development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cerebellar Purkinje cell layer development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within coronary vasculature development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fourth ventricle development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lateral ventricle development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in modification of postsynaptic actin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within myofibril assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuromuscular process controlling balance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nuclear migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within plasma membrane repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in postsynaptic actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of modification of postsynaptic actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of modification of postsynaptic actin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within retina development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within substrate-dependent cell migration, cell extension ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within third ventricle development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ventricular cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in actomyosin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    part_of myosin II complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of myosin II complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myosin II filament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in myosin II filament ISO
    Inferred from Sequence Orthology
    more info
     
    part_of myosin complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of polysome IEA
    Inferred from Electronic Annotation
    more info
     
    part_of polysome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
     
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    myosin-10
    Names
    MCH-B(B2)
    NMMHC II-b
    NMMHC-IIB
    cellular myosin heavy chain, type B
    myosin heavy chain, non-muscle IIb
    myosin heavy chain, nonmuscle type B
    myosin, heavy chain 10, non-muscle
    myosin, heavy polypeptide 10, non-muscle
    non-muscle myosin heavy chain B
    non-muscle myosin heavy chain IIb
    nonmuscle myosin heavy chain IIB
    nonmuscle myosin heavy chain-B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031520.2NP_113708.2  myosin-10

      Status: PROVISIONAL

      Source sequence(s)
      JACYVU010000220
      Related
      ENSRNOP00000077816.1, ENSRNOT00000105761.1
      Conserved Domains (3) summary
      cd14920
      Location:99771
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam01576
      Location:8481928
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3372
      Myosin_N; Myosin N-terminal SH3-like domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRatBN7.2 Primary Assembly

    Genomic

    1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

      Range
      53393901..53525174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597544.2XP_017453033.1  myosin-10 isoform X1

      Conserved Domains (10) summary
      cd14920
      Location:99802
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam00063
      Location:87802
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:8791959
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3472
      Myosin_N; Myosin N-terminal SH3-like domain
      cd16269
      Location:16311641
      GBP_C; coiled coil [structural motif]
      cl19511
      Location:11421253
      DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)
      cl19818
      Location:16761727
      DUF106; Integral membrane protein DUF106
      cl20817
      Location:15351641
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21509
      Location:12241371
      ApoLp-III_like; Apolipophorin-III and similar insect proteins
      cl24005
      Location:18001898
      DUF2570; Protein of unknown function (DUF2570)
    2. XM_008767881.3XP_008766103.1  myosin-10 isoform X1

      Related
      ENSRNOP00000095410.1, ENSRNOT00000107493.1
      Conserved Domains (10) summary
      cd14920
      Location:99802
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam00063
      Location:87802
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:8791959
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3472
      Myosin_N; Myosin N-terminal SH3-like domain
      cd16269
      Location:16311641
      GBP_C; coiled coil [structural motif]
      cl19511
      Location:11421253
      DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)
      cl19818
      Location:16761727
      DUF106; Integral membrane protein DUF106
      cl20817
      Location:15351641
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21509
      Location:12241371
      ApoLp-III_like; Apolipophorin-III and similar insect proteins
      cl24005
      Location:18001898
      DUF2570; Protein of unknown function (DUF2570)
    3. XM_006246821.4XP_006246883.1  myosin-10 isoform X2

      See identical proteins and their annotated locations for XP_006246883.1

      Related
      ENSRNOP00000087937.1, ENSRNOT00000113616.1
      Conserved Domains (10) summary
      cd14920
      Location:99792
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam00063
      Location:87792
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:8691949
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3472
      Myosin_N; Myosin N-terminal SH3-like domain
      cd16269
      Location:16211631
      GBP_C; coiled coil [structural motif]
      cl19511
      Location:11321243
      DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)
      cl19818
      Location:16661717
      DUF106; Integral membrane protein DUF106
      cl20817
      Location:15251631
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21509
      Location:12141361
      ApoLp-III_like; Apolipophorin-III and similar insect proteins
      cl24005
      Location:17901888
      DUF2570; Protein of unknown function (DUF2570)
    4. XM_039086920.1XP_038942848.1  myosin-10 isoform X3

      Related
      ENSRNOP00000062744.2, ENSRNOT00000065895.2
      Conserved Domains (3) summary
      cd14920
      Location:99781
      MYSc_Myh10; class II myosin heavy chain 10, motor domain
      pfam01576
      Location:8581938
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3372
      Myosin_N; Myosin N-terminal SH3-like domain
    Support Center