Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tap1provided by MGI
Official Full Name: transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)provided by MGI
Primary source: MGI:MGI:98483
See related: Ensembl:ENSMUSG00000037321 AllianceGenome:MGI:98483
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Y3; TAP; APT1; Ham1; MTP1; PSF1; ABC17; Abcb2; Ham-1; RING4; Tap-1
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This protein forms a heterodimer with Tap2 that transports short peptides from the cytosol into the endoplasmic reticulum lumen. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Expression: Broad expression in spleen adult (RPKM 66.8), thymus adult (RPKM 59.4) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34406530..34416199)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (34187556..34197225)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming.
Title: TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming.
TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors.
Title: TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors.
It transport class I antigens to cell surface of CD8 positive lymphocytes which have a vital role in liver inflammation like fructose-induced steatosis.
Title: Antigen peptide transporter 1 is involved in the development of fructose-induced hepatic steatosis in mice.
Knocking out Tap1 abolishes NMDAR-dependent LTD in area CA1 of adult mouse hippocampus and is accompanied by memory deficits. MHC class I expression could be an unexpected cause of disrupted synaptic plasticity and cognitive deficits.
Title: MHC class I immune proteins are critical for hippocampus-dependent memory and gate NMDAR-dependent hippocampal long-term depression.
Apoe(-/-)Tap1(-/-) mice develop atherosclerosis equal to Apoe(-/-) mice, indicating a minor role for CD8(+) T cells and TAP1-dependent antigen presentation in the disease process.
Title: TAP1-deficiency does not alter atherosclerosis development in Apoe-/- mice.
Role of metalloproteases in vaccinia virus epitope processing for transporter associated with antigen processing (TAP)-independent human leukocyte antigen (HLA)-B7 class I antigen presentation.
Title: Role of metalloproteases in vaccinia virus epitope processing for transporter associated with antigen processing (TAP)-independent human leukocyte antigen (HLA)-B7 class I antigen presentation.
Our data suggest that the normal influx of TAP-transported peptides in the ER during routine processing creates an efficient barrier for peptides from alternative processing routes.
Title: Peptide transporter TAP mediates between competing antigen sources generating distinct surface MHC class I peptide repertoires.
A complete overview is presented of the applicability of herpesvirus-encoded TAP and tapasin inhibitors in mouse cells of different genetic background.
Title: Inhibition of mouse TAP by immune evasion molecules encoded by non-murine herpesviruses.
downregulation of expression in PBMC of chronic hepatitis B patients
Title: Impaired antigen processing and presentation machinery is associated with immunotolerant state in chronic hepatitis B virus infection.
Our results do not support a role for MHC class I (TAP1) in adult neurogenesis, although it may still have a role in the maturation and integration of newborn neurons.
Title: Adult neurogenesis is unaffected by a functional knock-out of MHC class I in mice.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Chemically induced (ENU) (3) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH139868 (e-PCR)
- UniSTS:221952

M55637 (e-PCR)
- UniSTS:181008

M55637 (e-PCR)
- UniSTS:124955

Tap1 (e-PCR), detects polymorphism
- UniSTS:474694

AFM275yb9 (e-PCR)
- UniSTS:48881

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ABC-type peptide antigen transporter activity	EXP Inferred from Experiment more info	PubMed
enables ABC-type peptide antigen transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ABC-type peptide antigen transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables MHC class I protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables MHC class I protein binding	ISO Inferred from Sequence Orthology more info
enables MHC class Ib protein binding	ISO Inferred from Sequence Orthology more info
enables TAP1 binding	IBA Inferred from Biological aspect of Ancestor more info
enables TAP1 binding	ISO Inferred from Sequence Orthology more info
enables TAP2 binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	ISO Inferred from Sequence Orthology more info
contributes_to peptide antigen binding	ISO Inferred from Sequence Orthology more info
enables peptide antigen binding	ISO Inferred from Sequence Orthology more info
contributes_to peptide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables peptide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables tapasin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I	ISO Inferred from Sequence Orthology more info
involved_in cytosol to endoplasmic reticulum transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in peptide transport	ISO Inferred from Sequence Orthology more info
involved_in protection from natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MHC class I peptide loading complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MHC class I peptide loading complex	ISO Inferred from Sequence Orthology more info
part_of TAP complex	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in phagocytic vesicle membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: antigen peptide transporter 1

Names: ABC transporter, MHC, 1; ATP dependent transport protein family member; ATP-binding cassette sub-family B member 2; ATP-binding cassette transporter, major histocompatibility complex, 1; ATP-binding cassette, sub-family B (MDR/TAP), member 2; histocompatibility antigen modifier 1; peptide supply factor 1; peptide transporter PSF1; peptide transporter TAP1; transporter 1 ATP-binding cassette sub-family B; transporter 1, ABC (ATP binding cassette); transporter associated with antigen processing 1; transporter, ABC, MHC, 1; transporter, ATP-binding cassette, major histocompatibility complex, 1

NP_001155202.1

EC 7.4.2.14

NP_038711.2

EC 7.4.2.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161730.1 → NP_001155202.1 antigen peptide transporter 1 isoform 2

See identical proteins and their annotated locations for NP_001155202.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK152953, AK167485, AK171363

Consensus CDS

CCDS50072.1

UniProtKB/TrEMBL

Q3TBA3, Q3U543, Q3U6V4

Related

ENSMUSP00000039264.9, ENSMUST00000041633.15

Conserved Domains (3) summary

TIGR00958
Location:21 → 688

3a01208; Conjugate Transporter-2 (CT2) Family protein

pfam00664
Location:176 → 398

ABC_membrane; ABC transporter transmembrane region

cl21455
Location:440 → 668

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_013683.2 → NP_038711.2 antigen peptide transporter 1 isoform 1

See identical proteins and their annotated locations for NP_038711.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK152953, AK162731, AK167485

Consensus CDS

CCDS28643.1

UniProtKB/Swiss-Prot

P21958, Q62427

UniProtKB/TrEMBL

Q3U6V4

Related

ENSMUSP00000128401.2, ENSMUST00000170086.8

Conserved Domains (3) summary

TIGR00958
Location:21 → 716

3a01208; Conjugate Transporter-2 (CT2) Family protein

pfam00664
Location:176 → 434

ABC_membrane; ABC transporter transmembrane region

cl21455
Location:468 → 696

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases