Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) [ Mus musculus (house mouse) ]

    Gene ID: 21354, updated on 16-Oct-2021

    Summary

    Official Symbol
    Tap1provided by MGI
    Official Full Name
    transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)provided by MGI
    Primary source
    MGI:MGI:98483
    See related
    Ensembl:ENSMUSG00000037321
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Y3; TAP; APT1; Ham1; MTP1; PSF1; ABC17; Abcb2; Ham-1; RING4; Tap-1
    Summary
    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This protein forms a heterodimer with Tap2 that transports short peptides from the cytosol into the endoplasmic reticulum lumen. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
    Expression
    Broad expression in spleen adult (RPKM 66.8), thymus adult (RPKM 59.4) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tap1 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34406530..34416199)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34187556..34197225)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34324501..34334170)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, class II, locus Mb1 Neighboring gene proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) Neighboring gene proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) Neighboring gene transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ABC-type peptide antigen transporter activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables ABC-type peptide antigen transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ABC-type peptide antigen transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ABC-type peptide transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables MHC class I protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables MHC class I protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MHC class Ib protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MHC protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables TAP1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables TAP1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables TAP2 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to peptide antigen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide antigen binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to peptide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tapasin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of MHC class I peptide loading complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of MHC class I peptide loading complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of TAP complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in phagocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    antigen peptide transporter 1
    Names
    ABC transporter, MHC, 1
    ATP dependent transport protein family member
    ATP-binding cassette sub-family B member 2
    ATP-binding cassette transporter, major histocompatibility complex, 1
    ATP-binding cassette, sub-family B (MDR/TAP), member 2
    histocompatibility antigen modifier 1
    peptide supply factor 1
    peptide transporter PSF1
    peptide transporter TAP1
    transporter 1 ATP-binding cassette sub-family B
    transporter 1, ABC (ATP binding cassette)
    transporter associated with antigen processing 1
    transporter, ABC, MHC, 1
    transporter, ATP-binding cassette, major histocompatibility complex, 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161730.1NP_001155202.1  antigen peptide transporter 1 isoform 2

      See identical proteins and their annotated locations for NP_001155202.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK152953, AK167485, AK171363
      Consensus CDS
      CCDS50072.1
      UniProtKB/TrEMBL
      Q3TBA3, Q3U6V4
      Related
      ENSMUSP00000039264.9, ENSMUST00000041633.15
      Conserved Domains (3) summary
      TIGR00958
      Location:21688
      3a01208; Conjugate Transporter-2 (CT2) Family protein
      pfam00664
      Location:176398
      ABC_membrane; ABC transporter transmembrane region
      cl21455
      Location:440668
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_013683.2NP_038711.2  antigen peptide transporter 1 isoform 1

      See identical proteins and their annotated locations for NP_038711.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK152953, AK162731, AK167485
      Consensus CDS
      CCDS28643.1
      UniProtKB/Swiss-Prot
      P21958
      UniProtKB/TrEMBL
      Q3U6V4
      Related
      ENSMUSP00000128401.2, ENSMUST00000170086.8
      Conserved Domains (3) summary
      TIGR00958
      Location:21716
      3a01208; Conjugate Transporter-2 (CT2) Family protein
      pfam00664
      Location:176434
      ABC_membrane; ABC transporter transmembrane region
      cl21455
      Location:468696
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34406530..34416199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center