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    NR4A1 nuclear receptor subfamily 4 group A member 1 [ Homo sapiens (human) ]

    Gene ID: 3164, updated on 19-Jul-2021

    Summary

    Official Symbol
    NR4A1provided by HGNC
    Official Full Name
    nuclear receptor subfamily 4 group A member 1provided by HGNC
    Primary source
    HGNC:HGNC:7980
    See related
    Ensembl:ENSG00000123358 MIM:139139
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HMR; N10; TR3; NP10; GFRP1; NAK-1; NGFIB; NUR77
    Summary
    This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
    Expression
    Broad expression in adrenal (RPKM 103.3), ovary (RPKM 73.7) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See NR4A1 in Genome Data Viewer
    Location:
    12q13.13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (52022832..52059507)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (52416616..52453287)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene activin A receptor type 1B Neighboring gene RNA, U6 small nuclear 574, pseudogene Neighboring gene TAMALIN antisense RNA 1 Neighboring gene trafficking regulator and scaffold protein tamalin Neighboring gene Sharpr-MPRA regulatory region 2055 Neighboring gene uncharacterized LOC107984510 Neighboring gene NR4A1 antisense RNA Neighboring gene autophagy related 101 Neighboring gene uncharacterized LOC112268096 Neighboring gene small integral membrane protein 41 Neighboring gene olfactory receptor family 7 subfamily E member 47 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The gene expression of NR4A1 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed
    Vpr vpr HIV-1 Vpr downregulates expression of the gene coding for growth factor-inducible nuclear protein N10 in PHA-stimulated PBMC PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC9485

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables glucocorticoid receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration involved in sprouting angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to corticotropin-releasing hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to corticotropin-releasing hormone stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to fibroblast growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to vascular endothelial growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endothelial cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neurotransmitter secretion involved in regulation of skeletal muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of type B pancreatic cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to electrical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in skeletal muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear receptor subfamily 4 group A member 1
    Names
    ST-59
    TR3 orphan receptor
    early response protein NAK1
    growth factor-inducible nuclear protein N10
    hormone receptor
    nerve growth factor IB nuclear receptor variant 1
    nuclear hormone receptor NUR/77
    orphan nuclear receptor HMR
    orphan nuclear receptor TR3
    steroid receptor TR3
    testicular receptor 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001202233.2NP_001189162.1  nuclear receptor subfamily 4 group A member 1 isoform 2

      See identical proteins and their annotated locations for NP_001189162.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 4. The encoded isoform (2) has a shorter N-terminus compared to isoform 3.
      Source sequence(s)
      AC025259, AK297526, BG057763
      Consensus CDS
      CCDS55828.1
      UniProtKB/Swiss-Prot
      P22736
      Related
      ENSP00000353427.3, ENST00000360284.7
      Conserved Domains (2) summary
      cd07348
      Location:374611
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:278352
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    2. NM_001202234.2NP_001189163.1  nuclear receptor subfamily 4 group A member 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC025259, AK131566, BG057763
      Consensus CDS
      CCDS73471.1
      UniProtKB/TrEMBL
      F5GXF0, Q6ZMM6
      Related
      ENSP00000440864.1, ENST00000545748.5
      Conserved Domains (2) summary
      cd07348
      Location:415652
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:319393
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    3. NM_002135.5NP_002126.2  nuclear receptor subfamily 4 group A member 1 isoform 1

      See identical proteins and their annotated locations for NP_002126.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 4. The encoded isoform (1) has a shorter N-terminus compared to isoform 3. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC025259, BC016147
      Consensus CDS
      CCDS8818.1
      UniProtKB/Swiss-Prot
      P22736
      UniProtKB/TrEMBL
      A0A024R126
      Related
      ENSP00000243050.1, ENST00000243050.5
      Conserved Domains (3) summary
      cd07348
      Location:361598
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:265339
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
      pfam15694
      Location:135230
      Med26_M; Mediator complex subunit 26 middle domain
    4. NM_173157.3NP_775180.1  nuclear receptor subfamily 4 group A member 1 isoform 1

      See identical proteins and their annotated locations for NP_775180.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 4. The encoded isoform (1) has a shorter N-terminus compared to isoform 3. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC025259, BG057763, L13740
      Consensus CDS
      CCDS8818.1
      UniProtKB/Swiss-Prot
      P22736
      UniProtKB/TrEMBL
      A0A024R126
      Related
      ENSP00000378302.1, ENST00000394825.6
      Conserved Domains (3) summary
      cd07348
      Location:361598
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:265339
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
      pfam15694
      Location:135230
      Med26_M; Mediator complex subunit 26 middle domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      52022832..52059507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006719364.4XP_006719427.1  nuclear receptor subfamily 4 group A member 1 isoform X3

      See identical proteins and their annotated locations for XP_006719427.1

      UniProtKB/Swiss-Prot
      P22736
      UniProtKB/TrEMBL
      A0A024R126
      Conserved Domains (3) summary
      cd07348
      Location:361598
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:265339
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
      pfam15694
      Location:135230
      Med26_M; Mediator complex subunit 26 middle domain
    2. XM_005268822.3XP_005268879.1  nuclear receptor subfamily 4 group A member 1 isoform X1

      See identical proteins and their annotated locations for XP_005268879.1

      Conserved Domains (2) summary
      cd07348
      Location:433670
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:337411
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    3. XM_017019248.1XP_016874737.1  nuclear receptor subfamily 4 group A member 1 isoform X4

    4. XM_017019249.1XP_016874738.1  nuclear receptor subfamily 4 group A member 1 isoform X5

    5. XM_005268824.3XP_005268881.1  nuclear receptor subfamily 4 group A member 1 isoform X3

      See identical proteins and their annotated locations for XP_005268881.1

      UniProtKB/Swiss-Prot
      P22736
      UniProtKB/TrEMBL
      A0A024R126
      Conserved Domains (3) summary
      cd07348
      Location:361598
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:265339
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
      pfam15694
      Location:135230
      Med26_M; Mediator complex subunit 26 middle domain
    6. XM_006719363.1XP_006719426.1  nuclear receptor subfamily 4 group A member 1 isoform X3

      See identical proteins and their annotated locations for XP_006719426.1

      UniProtKB/Swiss-Prot
      P22736
      UniProtKB/TrEMBL
      A0A024R126
      Conserved Domains (3) summary
      cd07348
      Location:361598
      NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
      cd06969
      Location:265339
      NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
      pfam15694
      Location:135230
      Med26_M; Mediator complex subunit 26 middle domain
    7. XM_017019247.1XP_016874736.1  nuclear receptor subfamily 4 group A member 1 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_173158.1: Suppressed sequence

      Description
      NM_173158.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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