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    ITPKA inositol-trisphosphate 3-kinase A [ Homo sapiens (human) ]

    Gene ID: 3706, updated on 2-Aug-2021

    Summary

    Official Symbol
    ITPKAprovided by HGNC
    Official Full Name
    inositol-trisphosphate 3-kinase Aprovided by HGNC
    Primary source
    HGNC:HGNC:6178
    See related
    Ensembl:ENSG00000137825 MIM:147521
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IP3KA; IP3-3KA
    Summary
    Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]
    Expression
    Biased expression in brain (RPKM 9.4), duodenum (RPKM 6.8) and 5 other tissues See more
    Orthologs
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    Genomic context

    See ITPKA in Genome Data Viewer
    Location:
    15q15.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (41493874..41503555)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41786072..41795749)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RTF1 homolog, Paf1/RNA polymerase II complex component Neighboring gene uncharacterized LOC105370790 Neighboring gene Sharpr-MPRA regulatory region 6351 Neighboring gene leukocyte receptor tyrosine kinase Neighboring gene RNA polymerase II associated protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    GeneReviews: Not available

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of inositol-trisphosphate 3-kinase A (ITPKA) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol hexakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables inositol-1,4,5-trisphosphate 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dendritic spine maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inositol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of dendritic spine morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    inositol-trisphosphate 3-kinase A
    Names
    IP3 3-kinase A
    IP3K A
    inositol 1,4,5-trisphosphate 3-kinase A
    insP 3-kinase A
    NP_002211.1
    XP_011519824.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002220.3NP_002211.1  inositol-trisphosphate 3-kinase A

      See identical proteins and their annotated locations for NP_002211.1

      Status: REVIEWED

      Source sequence(s)
      AC087721, DB543073, X54938
      Consensus CDS
      CCDS10076.1
      UniProtKB/Swiss-Prot
      P23677
      Related
      ENSP00000260386.5, ENST00000260386.7
      Conserved Domains (1) summary
      pfam03770
      Location:245455
      IPK; Inositol polyphosphate kinase

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

      Range
      41493874..41503555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521522.2XP_011519824.1  inositol-trisphosphate 3-kinase A isoform X1

      Conserved Domains (1) summary
      pfam03770
      Location:73283
      IPK; Inositol polyphosphate kinase
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