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    FBXO32 F-box protein 32 [ Homo sapiens (human) ]

    Gene ID: 114907, updated on 19-Jul-2021

    Summary

    Official Symbol
    FBXO32provided by HGNC
    Official Full Name
    F-box protein 32provided by HGNC
    Primary source
    HGNC:HGNC:16731
    See related
    Ensembl:ENSG00000156804 MIM:606604
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Fbx32; MAFbx
    Summary
    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
    Expression
    Broad expression in endometrium (RPKM 28.7), heart (RPKM 22.1) and 18 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See FBXO32 in Genome Data Viewer
    Location:
    8q24.13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (123497889..123541206, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (124510129..124553446, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375737 Neighboring gene N-terminal glutamine amidase 1 Neighboring gene RN7SK pseudogene 155 Neighboring gene kelch like family member 38

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ32424, MGC33610

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to dexamethasone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to denervation involved in regulation of muscle adaptation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    F-box only protein 32
    Names
    atrogin 1
    muscle atrophy F-box protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242463.2NP_001229392.1  F-box only protein 32 isoform 3

      See identical proteins and their annotated locations for NP_001229392.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the coding region, compared to variant 1. This encodes a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC090193, AI077844, AK125888, EF143260
      Consensus CDS
      CCDS56553.1
      UniProtKB/Swiss-Prot
      Q969P5
      Related
      ENSP00000390790.2, ENST00000443022.2
      Conserved Domains (1) summary
      pfam06881
      Location:164209
      Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
    2. NM_058229.4NP_478136.1  F-box only protein 32 isoform 1

      See identical proteins and their annotated locations for NP_478136.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) has a longer and alternate 5' terminal sequence containing an in-frame translation start codon, as compared to variant 2. It encodes a longer isoform (1).
      Source sequence(s)
      AC090193, AI077844, AK056986, AK125888
      Consensus CDS
      CCDS6345.1
      UniProtKB/Swiss-Prot
      Q969P5
      UniProtKB/TrEMBL
      A0A024R9F3
      Related
      ENSP00000428205.1, ENST00000517956.5
      Conserved Domains (1) summary
      pfam06881
      Location:257302
      Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
    3. NM_148177.3NP_680482.1  F-box only protein 32 isoform 2

      See identical proteins and their annotated locations for NP_680482.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a shorter and alternate 5' terminal sequence lacking an in-frame translation start codon, as compared to variant 1. It uses a downstream in-frame translation start codon and encodes a shorter isoform (2).
      Source sequence(s)
      AC090193, AI077844, AK125888, BC024030, BC100020
      UniProtKB/TrEMBL
      I6L984, Q0VAQ6, Q498Y9
      Conserved Domains (1) summary
      pfam06881
      Location:120157
      Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      123497889..123541206 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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