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    Arsb arylsulfatase B [ Mus musculus (house mouse) ]

    Gene ID: 11881, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Arsbprovided by MGI
    Official Full Name
    arylsulfatase Bprovided by MGI
    Primary source
    MGI:MGI:88075
    See related
    Ensembl:ENSMUSG00000042082 AllianceGenome:MGI:88075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    As1; As-1; As-1r; As-1s; As-1t; As1-r; As1-s; As1-t; Asr-1; Ast-1; 1110007C02Rik
    Summary
    Enables arylsulfatase activity. Acts upstream of or within anterior head development. Located in cell surface. Is expressed in skeleton. Used to study mucopolysaccharidosis VI. Human ortholog(s) of this gene implicated in mucopolysaccharidosis VI. Orthologous to human ARSB (arylsulfatase B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 45.3), ovary adult (RPKM 25.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arsb in Genome Data Viewer
    Location:
    13 C3; 13 47.88 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (93908187..94079524)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (93771679..93943016)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene dimethylglycine dehydrogenase precursor Neighboring gene expressed sequence AW495222 Neighboring gene predicted gene, 41021 Neighboring gene microRNA 5624 Neighboring gene STARR-seq mESC enhancer starr_35297 Neighboring gene predicted gene, 24737 Neighboring gene STARR-seq mESC enhancer starr_35299 Neighboring gene STARR-seq mESC enhancer starr_35300 Neighboring gene cytochrome c, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Early enzyme replacement therapy prevents dental and craniofacial abnormalities in a mouse model of mucopolysaccharidosis type VI. Nagpal R, et al. Front Physiol, 2022. PMID 36213247, Free PMC Article
    2. Increased CHST15 follows decline in arylsulfatase B (ARSB) and disinhibition of non-canonical WNT signaling: potential impact on epithelial and mesenchymal identity. Bhattacharyya S, et al. Oncotarget, 2020 Jun 16. PMID 32595831, Free PMC Article
    3. Odiparcil, a potential glycosaminoglycans clearance therapy in mucopolysaccharidosis VI-Evidence from in vitro and in vivo models. Entchev E, et al. PLoS One, 2020. PMID 32413051, Free PMC Article
    4. Enzyme replacement therapy in mice lacking arylsulfatase B targets bone-remodeling cells, but not chondrocytes. Hendrickx G, et al. Hum Mol Genet, 2020 Mar 27. PMID 31943020, Free PMC Article
    5. Expression and Distribution of Arylsulfatase B are Closely Associated with Neuron Death in SOD1 G93A Transgenic Mice. Zhang J, et al. Mol Neurobiol, 2018 Feb. PMID 28124772

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arsb-deficient mice and the underlying bone cell deficits were fully corrected by enzyme replacement therapy in the trabecular compartment.
      Title: The Lysosomal Protein Arylsulfatase B Is a Key Enzyme Involved in Skeletal Turnover.
    2. Our data suggested that the abnormal expression and distribution of ARSB were closely associated with the neuron death in the SOD1 G93A transgenic mice.
      Title: Expression and Distribution of Arylsulfatase B are Closely Associated with Neuron Death in SOD1 G93A Transgenic Mice.
    3. Arylsulfatase B regulates versican expression by galectin-3 and AP-1 mediated transcriptional effects.
      Title: Arylsulfatase B regulates versican expression by galectin-3 and AP-1 mediated transcriptional effects.
    4. These studies reveal how carrageenan exposure can lead to transcriptional events in colonic epithelial cells through decline in arylsulfatase B activity, with subsequent impact on C4S, galectin-3, Sp1, and Wnt9A
      Title: Increased expression of colonic Wnt9A through Sp1-mediated transcriptional effects involving arylsulfatase B, chondroitin 4-sulfate, and galectin-3.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetylgalactosamine-4-sulfatase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables N-acetylgalactosamine-6-sulfatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables arylsulfatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfuric ester hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior head development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chondroitin sulfate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in colon epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dermatan sulfate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to estrogen ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to methylmercury ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to nutrient ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arylsulfatase B
    Names
    ASB
    G4S
    N-acetylgalactosamine-4-sulfatase
    arylsulfatase B complex
    arylsulfatase B regulation
    arylsulfatase B structural
    arylsulfatase B temporal regulation
    NP_033842.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009712.3 → NP_033842.3  arylsulfatase B precursor

      See identical proteins and their annotated locations for NP_033842.3

      Status: VALIDATED

      Source sequence(s)
      AC136976, AK140163, AK158312
      Consensus CDS
      CCDS36749.1
      UniProtKB/Swiss-Prot
      P50429, Q32KJ1, Q3TYV7, Q3U4Q6, Q8C404
      UniProtKB/TrEMBL
      A0A0R4J138
      Related
      ENSMUSP00000088964.5, ENSMUST00000091403.6
      Conserved Domains (2) summary
      COG3119
      Location:42 → 490
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cd16029
      Location:46 → 489
      4-S; N-acetylgalactosamine 4-sulfatase, also called arylsulftase B

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      93908187..94079524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50429.3 GenPept UniProtKB/Swiss-Prot:P50429

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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