Fosb FBJ osteosarcoma oncogene B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fosbprovided by MGI
Official Full Name: FBJ osteosarcoma oncogene Bprovided by MGI
Primary source: MGI:MGI:95575
See related: Ensembl:ENSMUSG00000003545 AllianceGenome:MGI:95575
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within cellular response to calcium ion. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; gut; male reproductive gland or organ; skin; and urinary system. Orthologous to human FOSB (FosB proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in frontal lobe adult (RPKM 2.7), small intestine adult (RPKM 1.8) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 9.56 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (19036621..19043970, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (19302696..19310118, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Manipulating DeltaFOSB in D1-Type Medium Spiny Neurons of the Nucleus Accumbens Reshapes Whole-Brain Functional Connectivity.
Title: Manipulating ΔFOSB in D1-Type Medium Spiny Neurons of the Nucleus Accumbens Reshapes Whole-Brain Functional Connectivity.
LINC00963-FOSB-mediated transcription activation of UBE3C enhances radioresistance of breast cancer cells by inducing ubiquitination-dependent protein degradation of TP73.
Title: LINC00963-FOSB-mediated transcription activation of UBE3C enhances radioresistance of breast cancer cells by inducing ubiquitination-dependent protein degradation of TP73.
Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates DeltaFosB and GluR2 expression.
Title: Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates ΔFosB and GluR2 expression.
Circuit-specific hippocampal DeltaFosB underlies resilience to stress-induced social avoidance.
Title: Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance.
DeltaFosB Requires Galanin, but not Leptin, to Increase Bone Mass via the Hypothalamus, but both are needed to increase Energy expenditure.
Title: ΔFosB Requires Galanin, but not Leptin, to Increase Bone Mass via the Hypothalamus, but both are needed to increase Energy expenditure.
Using transgenic expression of mouse DeltaFosB in the striatum of parkinsonian primates, study shows that elevated levels of DeltaFosB lead to l-Dopa-induced dyskinesia (LID) development in the absence of chronic l-Dopa exposure. The physiological and molecular changes associated with LID are also replicated in this model. These findings suggest that DeltaFosB elevation is responsible for LID generation.
Title: Role of striatal ΔFosB in l-Dopa-induced dyskinesias of parkinsonian nonhuman primates.
Fosb expression in the hippocampal subgranular zone is necessary for both hippocampal neurogenesis and memory formation.
Title: Hippocampal Subgranular Zone FosB Expression Is Critical for Neurogenesis and Learning.
data strongly support a dissociable cell-type-specific role for DeltaFosB in the nucleus accumbens in modulating aggression and aggression reward
Title: Cell-Type-Specific Role of ΔFosB in Nucleus Accumbens In Modulating Intermale Aggression.
Fosb-targeted histone acetylation in D2-MSNs or histone methylation in D1-MSNs promotes a stress-susceptible, depressive-like phenotype, while histone methylation in D2-MSNs or histone acetylation in D1-MSNs increases resilience to social stress as quantified by social interaction behavior and sucrose preference.
Title: Cell-Type-Specific Epigenetic Editing at the Fosb Gene Controls Susceptibility to Social Defeat Stress.
study provides key insights into functional domains regulated by FosB in the hippocampus, emphasizing remarkably different programs of gene regulation under physiological and pathological conditions
Title: Genome-wide profiling reveals functional diversification of ∆FosB gene targets in the hippocampus of an Alzheimer's disease mouse model.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein FosB

Names: osteosarcoma oncoprotein B FosB; protein fosB; transcription factor AP-1 subunit FosB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347586.1 → NP_001334515.1 protein FosB isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region which results in a frameshift, compared to variant 1. This difference results in a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1

Source sequence(s)

AC148988, AI846927, BC145082

Consensus CDS

CCDS85225.1

UniProtKB/TrEMBL

A0A140LIE4

Related

ENSMUSP00000146789.2, ENSMUST00000208446.2

Conserved Domains (1) summary

cd14721
Location:165 → 218

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
NM_008036.2 → NP_032062.1 protein FosB isoform 1

See identical proteins and their annotated locations for NP_032062.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC148988, AI846927, BU698478, BY337108, BY547195, CF356426, CK795975

Consensus CDS

CCDS20897.1

UniProtKB/Swiss-Prot

A0A140LIE4, P13346

UniProtKB/TrEMBL

A0A140LHW0, A2RSD4

Related

ENSMUSP00000003640.3, ENSMUST00000003640.4

Conserved Domains (1) summary

cd14721
Location:165 → 218

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain