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    Ubqln3 ubiquilin 3 [ Mus musculus (house mouse) ]

    Gene ID: 244178, updated on 2-May-2024

    Summary

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    Official Symbol
    Ubqln3provided by MGI
    Official Full Name
    ubiquilin 3provided by MGI
    Primary source
    MGI:MGI:3045291
    See related
    Ensembl:ENSMUSG00000051618 AllianceGenome:MGI:3045291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933400K24Rik
    Summary
    Predicted to enable polyubiquitin modification-dependent protein binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol. Is expressed in olfactory epithelium. Orthologous to human UBQLN3 (ubiquilin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 198.8) See more
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    Genomic context

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    Location:
    7 E3; 7 54.85 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (103789828..103792528, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (104140625..104143295, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily D member 1 Neighboring gene STARR-seq mESC enhancer starr_19730 Neighboring gene ubiquilin 5 Neighboring gene ubiquilin-like Neighboring gene olfactomedin 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ubqln3, a testis-specific gene, is dispensable for embryonic development and spermatogenesis in mice. Yuan S, et al. Mol Reprod Dev, 2015 Apr. PMID 25776854, Free PMC Article
    2. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ubqln3, a testis-specific gene, is dispensable for embryonic development and spermatogenesis in mice.
      Title: Ubqln3, a testis-specific gene, is dispensable for embryonic development and spermatogenesis in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquilin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001384184.1 → NP_001371113.1  ubiquilin-3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC123830
      UniProtKB/TrEMBL
      B2RWV8
      Conserved Domains (3) summary
      smart00727
      Location:212 → 256
      STI1; Heat shock chaperonin-binding motif
      cd14399
      Location:641 → 678
      UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
      cd01808
      Location:43 → 115
      Ubl_PLICs; ubiquitin-like (Ubl) domain found in eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

    2. NM_198623.3 → NP_941025.1  ubiquilin-3 isoform 2

      See identical proteins and their annotated locations for NP_941025.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC123830
      Consensus CDS
      CCDS21610.1
      UniProtKB/Swiss-Prot
      Q8C5U9
      UniProtKB/TrEMBL
      B2RWV8, Q497R3
      Conserved Domains (3) summary
      smart00727
      Location:189 → 233
      STI1; Heat shock chaperonin-binding motif
      cd14399
      Location:618 → 655
      UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
      cd01808
      Location:20 → 92
      Ubl_PLICs; ubiquitin-like (Ubl) domain found in eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      103789828..103792528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153120.1 → XP_036009013.1  ubiquilin-3 isoform X1

      UniProtKB/Swiss-Prot
      Q8C5U9
      UniProtKB/TrEMBL
      B2RWV8, Q497R3
      Related
      ENSMUSP00000055229.6, ENSMUST00000057254.6
      Conserved Domains (3) summary
      smart00727
      Location:189 → 233
      STI1; Heat shock chaperonin-binding motif
      cd14399
      Location:618 → 655
      UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
      cd01808
      Location:20 → 92
      Ubl_PLICs; ubiquitin-like (Ubl) domain found in eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C5U9.1 GenPept UniProtKB/Swiss-Prot:Q8C5U9

    Gene LinkOut

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