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    Maneal mannosidase, endo-alpha-like [ Mus musculus (house mouse) ]

    Gene ID: 215090, updated on 25-May-2024

    Summary

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    Official Symbol
    Manealprovided by MGI
    Official Full Name
    mannosidase, endo-alpha-likeprovided by MGI
    Primary source
    MGI:MGI:2684896
    See related
    Ensembl:ENSMUSG00000042763 AllianceGenome:MGI:2684896
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm50
    Summary
    Predicted to enable alpha-mannosidase activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Orthologous to human MANEAL (mannosidase endo-alpha like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 15.7), CNS E18 (RPKM 15.1) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Maneal in Genome Data Viewer
    Location:
    4 D2.2; 4 57.92 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124749032..124774731, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (124855239..124880938, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene metal response element binding transcription factor 1 Neighboring gene RIKEN cDNA 1110065P20 gene Neighboring gene predicted gene, 54256 Neighboring gene yrdC domain containing (E.coli) Neighboring gene RIKEN cDNA 1700125G02 gene Neighboring gene Eph receptor A10 Neighboring gene cell division cycle associated 8 Neighboring gene STARR-positive B cell enhancer ABC_E424

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Homology

    Clone Names

    • MGC86147

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glycoprotein endo-alpha-1,2-mannosidase-like protein
    NP_001007574.1
    XP_030109255.1
    XP_030109256.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007573.3 → NP_001007574.1  glycoprotein endo-alpha-1,2-mannosidase-like protein

      See identical proteins and their annotated locations for NP_001007574.1

      Status: VALIDATED

      Source sequence(s)
      AL606933
      Consensus CDS
      CCDS18629.1
      UniProtKB/Swiss-Prot
      Q3UVP2, Q6P1J0
      Related
      ENSMUSP00000066000.8, ENSMUST00000064444.8
      Conserved Domains (1) summary
      cd11574
      Location:100 → 441
      GH99; Glycoside hydrolase family 99, an endo-alpha-1,2-mannosidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      124749032..124774731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253396.1 → XP_030109256.1  glycoprotein endo-alpha-1,2-mannosidase-like protein isoform X2

      Conserved Domains (1) summary
      cd11574
      Location:24 → 224
      GH99; Glycoside hydrolase family 99, an endo-alpha-1,2-mannosidase

    2. XM_030253395.2 → XP_030109255.1  glycoprotein endo-alpha-1,2-mannosidase-like protein isoform X1

      Conserved Domains (1) summary
      cl01529
      Location:100 → 215
      GH99_GH71_like; Glycoside hydrolase families 71, 99, and related domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P1J0.1 GenPept UniProtKB/Swiss-Prot:Q6P1J0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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