Rab15 RAB15, member RAS oncogene family [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rab15provided by RGD
Official Full Name: RAB15, member RAS oncogene familyprovided by RGD
Primary source: RGD:735172
See related: Ensembl:ENSRNOG00000007364 AllianceGenome:RGD:735172
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTP binding activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; protein localization to plasma membrane; and secretion by cell. Predicted to be located in cilium; endosome membrane; and perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus; cytoplasmic vesicle; and plasma membrane. Orthologous to human RAB15 (RAB15, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 227.0), Lung (RPKM 109.3) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (101232740..101257388, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (95499584..95524073, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (99845952..99870320, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BI296877 (e-PCR)
- UniSTS:247622

RH133654 (e-PCR)
- UniSTS:216937

BI284471 (e-PCR)
- UniSTS:244125

RH138006 (e-PCR)
- UniSTS:220093

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	TAS Traceable Author Statement more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Rab protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter secretion	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of regulated secretory pathway	ISO Inferred from Sequence Orthology more info
involved_in protein secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ras-related protein Rab-15

Names: RAB15, member RAS onocogene family

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198749.2 → NP_942044.1 ras-related protein Rab-15

See identical proteins and their annotated locations for NP_942044.1

Status: PROVISIONAL

Source sequence(s)

BC094954

UniProtKB/Swiss-Prot

P35289, Q504L6

UniProtKB/TrEMBL

A6HCC2, A6HCC3

Related

ENSRNOP00000010043.3, ENSRNOT00000010043.6

Conserved Domains (1) summary

cd04117
Location:9 → 172

Rab15; Rab GTPase family 15 (Rab15)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

101232740..101257388 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063261727.1 → XP_063117797.1 ras-related protein Rab-15 isoform X1
XM_039112018.2 → XP_038967946.1 ras-related protein Rab-15 isoform X2

Conserved Domains (1) summary

cl38936
Location:1 → 126

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_039112017.2 → XP_038967945.1 ras-related protein Rab-15 isoform X2

Conserved Domains (1) summary

cl38936
Location:1 → 126

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases