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    Plek2 pleckstrin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314260, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Plek2provided by RGD
    Official Full Name
    pleckstrin 2provided by RGD
    Primary source
    RGD:1305786
    See related
    Ensembl:ENSRNOG00000010098 AllianceGenome:RGD:1305786
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol-3,4-bisphosphate binding activity; phosphatidylinositol-3,5-bisphosphate binding activity; and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in actin cytoskeleton reorganization and positive regulation of plasma membrane bounded cell projection assembly. Predicted to act upstream of or within actin cytoskeleton organization and positive regulation of cell projection organization. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human PLEK2 (pleckstrin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 61.3), Kidney (RPKM 15.9) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plek2 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (103434156..103452457, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (97700123..97719417, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (102076736..102095002, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V1 subunit D Neighboring gene eukaryotic translation initiation factor 2 subunit alpha Neighboring gene uncharacterized LOC102547797 Neighboring gene transmembrane protein 229B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis. Zhao B, et al. Haematologica, 2014 Jul. PMID 24747950, Free PMC Article
    2. PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization. Bach TL, et al. Blood, 2007 Feb 1. PMID 17008542, Free PMC Article
    3. Cloning and expression of pleckstrin 2, a novel member of the pleckstrin family. Inazu T, et al. Biochem Biophys Res Commun, 1999 Nov. PMID 10548495
    4. Pleckstrin 2, a widely expressed paralog of pleckstrin involved in actin rearrangement. Hu MH, et al. J Biol Chem, 1999 Jul 30. PMID 10419454
    5. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Dowler S, et al. Biochem J, 2000 Oct 1. PMID 11001876, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell projection organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of plasma membrane bounded cell projection assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114180.1 → NP_001107652.1  pleckstrin-2

      See identical proteins and their annotated locations for NP_001107652.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473947
      UniProtKB/TrEMBL
      A6HCF5, D4ACD5
      Related
      ENSRNOP00000014125.3, ENSRNOT00000014125.6
      Conserved Domains (4) summary
      cd04444
      Location:128 → 236
      DEP_PLEK2; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in pleckstrin 2-like proteins. Pleckstrin 2 is found in a wide variety of cell types, which suggest a more general role in signaling than pleckstrin 1. Pleckstrin-like proteins contain a central ...
      cd13301
      Location:3 → 113
      PH1_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 1
      cd13302
      Location:243 → 353
      PH2_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:5 → 95
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      103434156..103452457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261929.1 → XP_063117999.1  pleckstrin-2 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108035.1: Suppressed sequence

      Description
      NM_001108035.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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