Szt2 SZT2 subunit of KICSTOR complex [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Szt2provided by RGD
Full Name: SZT2 subunit of KICSTOR complexprovided by RGD
Primary source: RGD:1308616
See related: Ensembl:ENSRNOG00000028659 AllianceGenome:RGD:1308616
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1308616
Summary: Predicted to be involved in several processes, including cellular response to starvation; corpus callosum morphogenesis; and negative regulation of TORC1 signaling. Predicted to act upstream of or within pigmentation. Predicted to be located in lysosomal membrane. Predicted to be part of KICSTOR complex. Predicted to be active in peroxisome. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 18. Orthologous to human SZT2 (SZT2 subunit of KICSTOR complex). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 48.5), Thymus (RPKM 43.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 74

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (137182648..137229349, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (131897250..131943953, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (137192120..137238384, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH134176 (e-PCR)
- UniSTS:217458

RH143947 (e-PCR)
- UniSTS:233193

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within central nervous system development	ISO Inferred from Sequence Orthology more info
involved_in central nervous system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in corpus callosum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pigmentation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in post-embryonic development	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to lysosome	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient levels	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of GATOR1 complex	ISO Inferred from Sequence Orthology more info
part_of GATOR2 complex	ISO Inferred from Sequence Orthology more info
part_of KICSTOR complex	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: KICSTOR complex protein SZT2

Names: SZT2, KICSTOR complex subunit; protein SZT2; protein SZT2-like; seizure threshold 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427598.1 → NP_001414527.1 KICSTOR complex protein SZT2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

D3ZUQ8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

137182648..137229349 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238744.5 → XP_006238806.1 KICSTOR complex protein SZT2 isoform X1

UniProtKB/TrEMBL

D3ZUQ8
XM_039111188.2 → XP_038967116.1 KICSTOR complex protein SZT2 isoform X2
XM_063287980.1 → XP_063144050.1 KICSTOR complex protein SZT2 isoform X3
XM_039111189.2 → XP_038967117.1 KICSTOR complex protein SZT2 isoform X3