Fut8 fucosyltransferase 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fut8provided by RGD
Official Full Name: fucosyltransferase 8provided by RGD
Primary source: RGD:1303096
See related: Ensembl:ENSRNOG00000008451 AllianceGenome:RGD:1303096
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable glycoprotein 6-alpha-L-fucosyltransferase activity. Predicted to be involved in GDP-L-fucose metabolic process; N-glycan fucosylation; and protein N-linked glycosylation via asparagine. Predicted to act upstream of or within several processes, including N-glycan processing; cell surface receptor signaling pathway; and regulation of cellular response to oxidative stress. Predicted to be located in Golgi cisterna membrane. Predicted to be integral component of membrane. Orthologous to human FUT8 (fucosyltransferase 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 118.8), Kidney (RPKM 102.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (101682354..101909784)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (95949246..96176677)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (100305957..100537208)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The cDNAs encoding the rat alpha1,6-fucosyltransferase (FucT VIII) were cloned from YB2/0 cells by polymerase chain reaction-based and 5' RNA-Ligase-Mediated RACE methods.
Title: Molecular cloning, characterization, genomic organization and promoter analysis of the α1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0.

Submit: New GeneRIF Correction

General gene information

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Markers

Fut8 (e-PCR), detects polymorphism
- UniSTS:256668

RH127620 (e-PCR)
- UniSTS:210930

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables alpha-(1->6)-fucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-(1->6)-fucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glycoprotein 6-alpha-L-fucosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycoprotein 6-alpha-L-fucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glycoprotein 6-alpha-L-fucosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glycosyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in GDP-L-fucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in GDP-L-fucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in GDP-L-fucose metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in N-glycan fucosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-glycan fucosylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within N-glycan fucosylation	ISO Inferred from Sequence Orthology more info
involved_in N-glycan processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within N-glycan processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
involved_in fibroblast migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation via asparagine	IEA Inferred from Electronic Annotation more info
involved_in protein N-linked glycosylation via asparagine	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation via asparagine	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in receptor metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within receptor metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in respiratory gaseous exchange by respiratory system	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-(1,6)-fucosyltransferase

Names: GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; GDP-fucose--glycoprotein fucosyltransferase; alpha1-6FucT; fucosyltransferase 8 (alpha (1,6) fucosyltransferase); glycoprotein 6-alpha-L-fucosyltransferase

NP_001002289.2

EC 2.4.1.68

NP_001399118.1

EC 2.4.1.68

XP_038968588.1

EC 2.4.1.68

XP_063118317.1

EC 2.4.1.68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002289.2 → NP_001002289.2 alpha-(1,6)-fucosyltransferase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A6HCC9, D4IGX4, D4IGX5

Related

ENSRNOP00000089026.1, ENSRNOT00000096219.1
NM_001412189.1 → NP_001399118.1 alpha-(1,6)-fucosyltransferase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A6HCC9, D4IGX4, D4IGX5

Related

ENSRNOP00000011220.2, ENSRNOT00000011220.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

101682354..101909784

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039112660.2 → XP_038968588.1 alpha-(1,6)-fucosyltransferase isoform X2

UniProtKB/Swiss-Prot

Q6EV76

Conserved Domains (2) summary

cd11300
Location:208 → 533

Fut8_like; Alpha 1-6-fucosyltransferase

cd11792
Location:540 → 594

SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)
XM_063262247.1 → XP_063118317.1 alpha-(1,6)-fucosyltransferase isoform X1

UniProtKB/TrEMBL

A6HCC9, D4IGX4, D4IGX5