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    Ighg Immunoglobulin heavy chain (gamma polypeptide) [ Mus musculus (house mouse) ]

    Gene ID: 380794, updated on 25-Jan-2024

    Summary

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    Official Symbol
    Ighgprovided by MGI
    Official Full Name
    Immunoglobulin heavy chain (gamma polypeptide)provided by MGI
    Primary source
    MGI:MGI:2144967
    See related
    AllianceGenome:MGI:2144967
    Gene type
    protein coding
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IGHG2A
    Summary
    Enables immunoglobulin receptor binding activity. Acts upstream of or within response to bacterium. Predicted to be part of immunoglobulin complex, circulating. Predicted to be active in external side of plasma membrane. Used to study type 1 diabetes mellitus. [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    not in current annotation release
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    Genomic context

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    Location:
    12 F2; 12 62.1 cM

    Bibliography

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    Related articles in PubMed

    1. Sequence analysis of anti-AChR antibodies in experimental autoimmune myasthenia gravis. Graus Y, et al. J Immunol, 1995 Jun 15. PMID 7539019
    2. O-glycosylation in hinge region of mouse immunoglobulin G2b. Kim H, et al. J Biol Chem, 1994 Apr 22. PMID 7512967
    3. Structure of the constant and 3' untranslated regions of the murine gamma 2b heavy chain messenger RNA. Tucker PW, et al. Science, 1979 Dec 14. PMID 117548
    4. Mouse immunoglobulin allotypes: post-duplication divergence of gamma 2a and gamma 2b chain genes. Ollo R, et al. Nature, 1982 Apr 22. PMID 6803173
    5. Structure of the constant and 3' untranslated regions of the murine Balb/c gamma 2a heavy chain messenger RNA. Sikorav JL, et al. Nucleic Acids Res, 1980 Jul 25. PMID 6777755, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Clone Names

    • MGC102604, MGC102659

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Fc-gamma receptor I complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables immunoglobulin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables immunoglobulin receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antibacterial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in complement activation, classical pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of IgG immunoglobulin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of immunoglobulin complex, circulating IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Names
    Immunoglobulin heavy chain (gamma polypeptide)

    NCBI Reference Sequences (RefSeq)

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    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_212451.1: Suppressed sequence

      Description
      NM_212451.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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