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    Atp8b2 ATPase, class I, type 8B, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 54667, updated on 28-Apr-2024

    Summary

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    Official Symbol
    Atp8b2provided by MGI
    Official Full Name
    ATPase, class I, type 8B, member 2provided by MGI
    Primary source
    MGI:MGI:1859660
    See related
    Ensembl:ENSMUSG00000060671 AllianceGenome:MGI:1859660
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Id
    Summary
    Predicted to enable phosphatidylcholine flippase activity. Predicted to be involved in Golgi organization and phospholipid translocation. Predicted to act upstream of or within lipid transport. Predicted to be located in Golgi apparatus. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane and trans-Golgi network. Is expressed in several structures, including hindbrain; limb; sensory organ; skeleton; and ventral grey horn. Orthologous to human ATP8B2 (ATPase phospholipid transporting 8B2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 20.9), limb E14.5 (RPKM 18.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 F1; 3 39.19 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89846795..89870645, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89939481..89963338, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene src homology 2 domain-containing transforming protein E Neighboring gene STARR-positive B cell enhancer ABC_E9217 Neighboring gene STARR-positive B cell enhancer ABC_E4556 Neighboring gene interleukin 6 receptor, alpha Neighboring gene STARR-seq mESC enhancer starr_08265 Neighboring gene STARR-positive B cell enhancer ABC_E2670 Neighboring gene STARR-seq mESC enhancer starr_08266 Neighboring gene STARR-positive B cell enhancer ABC_E7921 Neighboring gene STARR-positive B cell enhancer ABC_E7922 Neighboring gene aquaporin 10, pseudogene Neighboring gene predicted gene, 24046 Neighboring gene STARR-positive B cell enhancer ABC_E4557 Neighboring gene HCLS1 associated X-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MIDA1, a protein associated with Id, regulates cell growth. Shoji W, et al. J Biol Chem, 1995 Oct 20. PMID 7559602
    2. Activated Notch1 target genes during embryonic cell differentiation depend on the cellular context and include lineage determinants and inhibitors. Meier-Stiegen F, et al. PLoS One, 2010 Jul 8. PMID 20628604, Free PMC Article
    3. A trans-eQTL network regulates osteoclast multinucleation and bone mass. Pereira M, et al. Elife, 2020 Jun 19. PMID 32553114, Free PMC Article
    4. Differential expression of putative transbilayer amphipath transporters. Halleck MS, et al. Physiol Genomics, 1999 Nov 11. PMID 11015572
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Notch1 activates the expression of regulatory transcription factors such as Sox9, Pax6, Runx1, Myf5 and Id proteins that are critically involved in lineage decisions in the absence of protein synthesis.
      Title: Activated Notch1 target genes during embryonic cell differentiation depend on the cellular context and include lineage determinants and inhibitors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylcholine flippase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phospholipid-translocating ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid-transporting ATPase ID
    Names
    Atpase 8B2, p type
    P4-ATPase flippase complex alpha subunit ATP8B2
    probable phospholipid-transporting ATPase ID
    NP_001074651.2
    NP_001355579.1
    XP_006501778.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081182.3 → NP_001074651.2  phospholipid-transporting ATPase ID isoform 2

      See identical proteins and their annotated locations for NP_001074651.2

      Status: VALIDATED

      Source sequence(s)
      AC163616
      Consensus CDS
      CCDS38497.2
      UniProtKB/TrEMBL
      D3YXQ5, E9QAL4
      Related
      ENSMUSP00000128423.2, ENSMUST00000168276.8
      Conserved Domains (1) summary
      cd02073
      Location:31 → 972
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    2. NM_001368650.2 → NP_001355579.1  phospholipid-transporting ATPase ID isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163616
      Consensus CDS
      CCDS89658.1
      UniProtKB/Swiss-Prot
      P98199
      UniProtKB/TrEMBL
      D3YXQ5
      Related
      ENSMUSP00000063384.8, ENSMUST00000069805.14
      Conserved Domains (1) summary
      cd02073
      Location:50 → 991
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      89846795..89870645 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501715.4 → XP_006501778.1  phospholipid-transporting ATPase ID isoform X1

      See identical proteins and their annotated locations for XP_006501778.1

      UniProtKB/TrEMBL
      D3YXQ5, E9QAL4
      Conserved Domains (1) summary
      cd02073
      Location:31 → 972
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P98199.2 GenPept UniProtKB/Swiss-Prot:P98199

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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