Nr3c2 nuclear receptor subfamily 3, group C, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nr3c2provided by MGI
Official Full Name: nuclear receptor subfamily 3, group C, member 2provided by MGI
Primary source: MGI:MGI:99459
See related: Ensembl:ENSMUSG00000031618 AllianceGenome:MGI:99459
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MR; Mlr
Summary: Enables steroid binding activity. Involved in regulation of postsynaptic membrane potential and regulation of synaptic vesicle exocytosis. Acts upstream of or within cellular sodium ion homeostasis and excretion. Located in GABA-ergic synapse. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system and genitourinary system. Used to study autosomal dominant pseudohypoaldosteronism type 1. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1 and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in colon adult (RPKM 12.0), frontal lobe adult (RPKM 3.4) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C1; 8 36.34 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (77626422..77971641)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (76898083..77245012)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Atlas of cardiac endothelial cell enhancer elements linking the mineralocorticoid receptor to pathological gene expression.
Title: Atlas of cardiac endothelial cell enhancer elements linking the mineralocorticoid receptor to pathological gene expression.
NR3C2 activates LCN2 transcription to promote endoplasmic reticulum stress and cell apoptosis in ischemic cerebral infarction.
Title: NR3C2 activates LCN2 transcription to promote endoplasmic reticulum stress and cell apoptosis in ischemic cerebral infarction.
Brown adipocyte mineralocorticoid receptor deficiency impairs metabolic regulation in diet-induced obese mice.
Title: Brown adipocyte mineralocorticoid receptor deficiency impairs metabolic regulation in diet-induced obese mice.
Mineralocorticoid receptor knockout in Schwann cells alters myelin sheath thickness.
Title: Mineralocorticoid receptor knockout in Schwann cells alters myelin sheath thickness.
Conditional Ablation of Glucocorticoid and Mineralocorticoid Receptors from Cochlear Supporting Cells Reveals Their Differential Roles for Hearing Sensitivity and Dynamics of Recovery from Noise-Induced Hearing Loss.
Title: Conditional Ablation of Glucocorticoid and Mineralocorticoid Receptors from Cochlear Supporting Cells Reveals Their Differential Roles for Hearing Sensitivity and Dynamics of Recovery from Noise-Induced Hearing Loss.
Smooth muscle mineralocorticoid receptor as an epigenetic regulator of vascular ageing.
Title: Smooth muscle mineralocorticoid receptor as an epigenetic regulator of vascular ageing.
miR-324-5p and miR-30c-2-3p Alter Renal Mineralocorticoid Receptor Signaling under Hypertonicity.
Title: miR-324-5p and miR-30c-2-3p Alter Renal Mineralocorticoid Receptor Signaling under Hypertonicity.
Aldosterone Inhibits In Vitro Myogenesis by Increasing Intracellular Oxidative Stress via Mineralocorticoid Receptor.
Title: Aldosterone Inhibits In Vitro Myogenesis by Increasing Intracellular Oxidative Stress via Mineralocorticoid Receptor.
Myeloid mineralocorticoid receptors contribute to skeletal muscle repair in muscular dystrophy and acute muscle injury.
Title: Myeloid mineralocorticoid receptors contribute to skeletal muscle repair in muscular dystrophy and acute muscle injury.
Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5.
Title: Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5.

Submit: New GeneRIF Correction See all GeneRIFs (87)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G42952 (e-PCR)
- UniSTS:94839

PMC124545P1 (e-PCR)
- UniSTS:270474

NoName (e-PCR)
- UniSTS:235932

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables TBP-class protein binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables estrogen response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone acetyltransferase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear steroid receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables steroid binding	IDA Inferred from Direct Assay more info	PubMed
enables steroid binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in angiotensin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to aldosterone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular sodium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular steroid hormone receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in potassium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of blood volume by renal aldosterone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane potential	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of potassium:proton exchanging ATPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within renal sodium excretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density, intracellular component	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone cytoplasmic component	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: mineralocorticoid receptor

Names: aldosterone receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083906.3 → NP_001077375.1 mineralocorticoid receptor

See identical proteins and their annotated locations for NP_001077375.1

Status: VALIDATED

Source sequence(s)

AC116768, AC118019, AC119248

Consensus CDS

CCDS40393.1

UniProtKB/Swiss-Prot

Q8VII8, Q8VII9

UniProtKB/TrEMBL

A3KN90

Related

ENSMUSP00000105538.2, ENSMUST00000109912.8

Conserved Domains (3) summary

cd07075
Location:733 → 980

NR_LBD_MR; Ligand binding domain of the mineralocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:599 → 673

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam05109
Location:200 → 394

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
NM_001426575.1 → NP_001413504.1 mineralocorticoid receptor

Status: VALIDATED

Source sequence(s)

AC116768, AC118019, AC119248

UniProtKB/TrEMBL

A3KN90
NM_001426576.1 → NP_001413505.1 mineralocorticoid receptor

Status: VALIDATED

Source sequence(s)

AC116768, AC118019, AC119248

UniProtKB/TrEMBL

A3KN90
NM_001426577.1 → NP_001413506.1 mineralocorticoid receptor

Status: VALIDATED

Source sequence(s)

AC116768, AC118019, AC119248

UniProtKB/TrEMBL

A3KN90
NM_001426578.1 → NP_001413507.1 mineralocorticoid receptor

Status: VALIDATED

Source sequence(s)

AC116768, AC118019, AC119248

UniProtKB/TrEMBL

A3KN90

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

77626422..77971641

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153720.1 → XP_036009613.1 mineralocorticoid receptor isoform X2

UniProtKB/TrEMBL

D6RIL1

Related

ENSMUSP00000118222.2, ENSMUST00000148106.8

Conserved Domains (2) summary

cd07172
Location:599 → 671

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam15921
Location:112 → 308

CCDC158; Coiled-coil domain-containing protein 158