S100a9 S100 calcium binding protein A9 (calgranulin B) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: S100a9provided by MGI
Official Full Name: S100 calcium binding protein A9 (calgranulin B)provided by MGI
Primary source: MGI:MGI:1338947
See related: Ensembl:ENSMUSG00000056071 AllianceGenome:MGI:1338947
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p14; Cagb; GAGB; L1Ag; BEE22; MRP14; 60B8Ag
Summary: Predicted to enable calcium ion binding activity and calcium-dependent protein binding activity. Involved in peptidyl-cysteine S-nitrosylation; positive regulation of blood coagulation; and regulation of translation. Acts upstream of or within several processes, including actin cytoskeleton reorganization; astrocyte development; and regulation of integrin biosynthetic process. Predicted to be located in cell junction; cytosol; and nucleoplasm. Predicted to be active in cytoplasm; extracellular space; and nucleus. Is expressed in several structures, including jaw; liver; otic capsule; skeleton; and spleen red pulp. Human ortholog(s) of this gene implicated in myocarditis. Orthologous to human S100A9 (S100 calcium binding protein A9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 1633.0), liver E14 (RPKM 204.2) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.91 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (90599937..90603028, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (90692630..90695721, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MDSC-derived S100A8/9 contributes to lupus pathogenesis by promoting TLR7-mediated activation of macrophages and dendritic cells.
Title: MDSC-derived S100A8/9 contributes to lupus pathogenesis by promoting TLR7-mediated activation of macrophages and dendritic cells.
Deficiency of S100A8/A9 attenuates pulmonary microvascular leakage in septic mice.
Title: Deficiency of S100A8/A9 attenuates pulmonary microvascular leakage in septic mice.
S100A9[-/-] alleviates LPS-induced acute lung injury by regulating M1 macrophage polarization and inhibiting pyroptosis via the TLR4/MyD88/NFkappaB signaling axis.
Title: S100A9(-/-) alleviates LPS-induced acute lung injury by regulating M1 macrophage polarization and inhibiting pyroptosis via the TLR4/MyD88/NFκB signaling axis.
CD146 deficiency aggravates chronic obstructive pulmonary disease via the increased production of S100A9 and MMP-9 in macrophages.
Title: CD146 deficiency aggravates chronic obstructive pulmonary disease via the increased production of S100A9 and MMP-9 in macrophages.
Effect of Proinflammatory S100A9 Protein on Migration and Proliferation of Microglial Cells.
Title: Effect of Proinflammatory S100A9 Protein on Migration and Proliferation of Microglial Cells.
Inhibition of S100A9 alleviates neurogenic pulmonary edema after subarachnoid hemorrhage.
Title: Inhibition of S100A9 alleviates neurogenic pulmonary edema after subarachnoid hemorrhage.
S100A8/A9-alarmin promotes local myeloid-derived suppressor cell activation restricting severe autoimmune arthritis.
Title: S100A8/A9-alarmin promotes local myeloid-derived suppressor cell activation restricting severe autoimmune arthritis.
S100a9 inhibits Atg9a transcription and participates in suppression of autophagy in cardiomyocytes induced by beta1-adrenoceptor autoantibodies.
Title: S100a9 inhibits Atg9a transcription and participates in suppression of autophagy in cardiomyocytes induced by β(1)-adrenoceptor autoantibodies.
A positive feedback cycle between the alarmin S100A8/A9 and NLRP3 inflammasome-GSDMD signalling reinforces the innate immune response in Candida albicans keratitis.
Title: A positive feedback cycle between the alarmin S100A8/A9 and NLRP3 inflammasome-GSDMD signalling reinforces the innate immune response in Candida albicans keratitis.
S100A9 Drives the Chronification of Psoriasiform Inflammation by Inducing IL-23/Type 3 Immunity.
Title: S100A9 Drives the Chronification of Psoriasiform Inflammation by Inducing IL-23/Type 3 Immunity.

Submit: New GeneRIF Correction See all GeneRIFs (161)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

S100a9 (e-PCR), detects polymorphism
- UniSTS:465408

AW546964 (e-PCR)
- UniSTS:178886

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in astrocyte development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within astrocyte development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in autocrine signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in autocrine signaling	ISO Inferred from Sequence Orthology more info
involved_in autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in chronic inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in endothelial cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within leukocyte chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukocyte migration involved in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte migration involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in modulation of process of another organism	ISO Inferred from Sequence Orthology more info
involved_in neutrophil aggregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil aggregation	ISO Inferred from Sequence Orthology more info
involved_in neutrophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of peptide secretion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of peptide secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-cysteine S-nitrosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-cysteine S-nitrosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-cysteine S-trans-nitrosylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptide secretion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of peptide secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of integrin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of integrin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of respiratory burst involved in inflammatory response	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of toll-like receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of S100A9 complex	ISO Inferred from Sequence Orthology more info
part_of calprotectin complex	ISO Inferred from Sequence Orthology more info
is_active_in cornified envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein S100-A9

Names: S100 calcium-binding protein A9; leukocyte L1 complex heavy chain; migration inhibitory factor-related protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001281852.1 → NP_001268781.1 protein S100-A9

See identical proteins and their annotated locations for NP_001268781.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC122425, AK143826, BC027635, BF732133

Consensus CDS

CCDS17543.1

UniProtKB/Swiss-Prot

P31725

UniProtKB/TrEMBL

Q3UP42

Related

ENSMUSP00000070842.6, ENSMUST00000069960.12

Conserved Domains (2) summary

cd05030
Location:7 → 95

calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...

pfam13499
Location:32 → 79

EF-hand_7; EF-hand domain pair
NM_009114.3 → NP_033140.1 protein S100-A9

See identical proteins and their annotated locations for NP_033140.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC122425, BC027635, BF732133, BY112406

Consensus CDS

CCDS17543.1

UniProtKB/Swiss-Prot

P31725

UniProtKB/TrEMBL

Q3UP42

Related

ENSMUSP00000112843.2, ENSMUST00000117167.2

Conserved Domains (2) summary

cd05030
Location:7 → 95

calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...

pfam13499
Location:32 → 79

EF-hand_7; EF-hand domain pair