ALD4 aldehyde dehydrogenase (NADP(+)) ALD4 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: ALD4
Gene description: aldehyde dehydrogenase (NADP(+)) ALD4
Primary source: SGD:S000005901
Locus tag: YOR374W
See related: AllianceGenome:SGD:S000005901
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ALD7
Summary: Enables aldehyde dehydrogenase (NAD+) activity. Involved in NADPH regeneration; ethanol metabolic process; and monocarboxylic acid metabolic process. Located in mitochondrial nucleoid. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); isolated microphthalmia 8; and liver disease (multiple). Orthologous to several human genes including ALDH1A1 (aldehyde dehydrogenase 1 family member A1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ALD4 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (1039840..1041399)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Robust assembly of the aldehyde dehydrogenase Ald4p in Saccharomyces cerevisiae.
Title: Robust assembly of the aldehyde dehydrogenase Ald4p in Saccharomyces cerevisiae.
there are two sources of mitochondrial NADPH in yeast: one is the mitochondrial Pos5p-NADH kinase reaction and the other is the mitochondrial Pos5p-NAD kinase reaction followed by the mitochondrial Ald4/5 reaction.
Title: Two sources of mitochondrial NADPH in the yeast Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables aldehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldehyde dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables aldehyde dehydrogenase (NAD+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables aldehyde dehydrogenase [NAD(P)+] activity	IDA Inferred from Direct Assay more info	PubMed
enables aldehyde dehydrogenase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADPH regeneration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in acetate biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ethanol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyruvate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aldehyde dehydrogenase (NADP(+)) ALD4

NP_015019.1

EC 1.2.1.4

Mitochondrial aldehyde dehydrogenase; required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed; can substitute for cytosolic NADP-dependent aldehyde dehydrogenase when directed to the cytosol; human homolog ALDH2 can complement yeast ald4 mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

1039840..1041399

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183794.1 → NP_015019.1 TPA: aldehyde dehydrogenase (NADP(+)) ALD4 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015019.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W367, P46367, Q08898

UniProtKB/TrEMBL

A0A6A5Q4N4, A6ZPK2, B5VSP8, C8ZHC2, G2WNN4, N1NZ13

Conserved Domains (1) summary

cd07091
Location:42 → 514

ALDH_F1-2_Ald2-like; ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins