U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    FNBP1 formin binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 23048, updated on 3-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    FNBP1provided by HGNC
    Official Full Name
    formin binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:17069
    See related
    Ensembl:ENSG00000187239 MIM:606191; AllianceGenome:HGNC:17069
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBP17
    Summary
    The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 19.9), spleen (RPKM 17.6) and 24 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    9q34.11
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (129887187..130053879, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (142091913..142247931, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (132649466..132805468, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20391 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:132597987-132598487 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:132601680-132602180 Neighboring gene chromosome 9 open reading frame 78 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29123 Neighboring gene Sharpr-MPRA regulatory region 12255 Neighboring gene ubiquitin specific peptidase 20 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:132632499-132632998 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:132636644-132637144 Neighboring gene Sharpr-MPRA regulatory region 12063 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:132647083-132647764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29125 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:132651249-132652136 Neighboring gene microRNA 6855 Neighboring gene Sharpr-MPRA regulatory region 3297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29128 Neighboring gene Sharpr-MPRA regulatory region 1290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29133 Neighboring gene Sharpr-MPRA regulatory region 9235 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29144 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:132786300-132786450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29146 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:132797471-132797971 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:132796970-132797470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20395 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20396 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20397 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:132811133-132811633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20398 Neighboring gene G protein-coupled receptor 107 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:132878169-132878714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:132881191-132882139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20399 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29149 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:132904135-132904908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:132905683-132906456 Neighboring gene GPR107 adjacent cis regulating lncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Membrane tension sensing molecule-FNBP1 is a prognostic biomarker related to immune infiltration in BRCA, LUAD and STAD. Wang Z, et al. BMC Immunol, 2022 Jan 8. PMID 34998385, Free PMC Article
    2. High formin binding protein 17 (FBP17) expression indicates poor differentiation and invasiveness of ductal carcinomas. Suman P, et al. Sci Rep, 2020 Jul 14. PMID 32665637, Free PMC Article
    3. An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation. Echarri A, et al. Nat Commun, 2019 Dec 20. PMID 31862885, Free PMC Article
    4. High expression of FBP17 in invasive breast cancer cells promotes invadopodia formation. Suman P, et al. Med Oncol, 2018 Apr 12. PMID 29651632
    5. Feedback regulation between plasma membrane tension and membrane-bending proteins organizes cell polarity during leading edge formation. Tsujita K, et al. Nat Cell Biol, 2015 Jun. PMID 25938814

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FNBP1 Facilitates Cervical Cancer Cell Survival by the Constitutive Activation of FAK/PI3K/AKT/mTOR Signaling.
      Title: FNBP1 Facilitates Cervical Cancer Cell Survival by the Constitutive Activation of FAK/PI3K/AKT/mTOR Signaling.
    2. Wild-type p53 suppresses formin-binding protein-17 (FBP17) to reduce invasion.
      Title: Wild-type p53 suppresses formin-binding protein-17 (FBP17) to reduce invasion.
    3. Membrane tension sensing molecule-FNBP1 is a prognostic biomarker related to immune infiltration in BRCA, LUAD and STAD.
      Title: Membrane tension sensing molecule-FNBP1 is a prognostic biomarker related to immune infiltration in BRCA, LUAD and STAD.
    4. Sp1-Induced FNBP1 Drives Rigorous 3D Cell Motility in EMT-Type Gastric Cancer Cells.
      Title: Sp1-Induced FNBP1 Drives Rigorous 3D Cell Motility in EMT-Type Gastric Cancer Cells.
    5. High formin binding protein 17 (FBP17) expression indicates poor differentiation and invasiveness of ductal carcinomas.
      Title: High formin binding protein 17 (FBP17) expression indicates poor differentiation and invasiveness of ductal carcinomas.
    6. Study shows that plasma membrane (PM) mechanoadaptation is controlled by a tension-sensing pathway composed of c-Abl tyrosine kinase and membrane curvature regulator FBP17. FBP17 is recruited to caveolae to induce the formation of caveolar rosettes. FBP17 deficient cells have reduced rosette density, lack PM tension buffering capacity under osmotic shock, and cannot adapt to mechanical strain.
      Title: An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation.
    7. FBP17 and CIP4 prime the membrane of resting cells for fast endophilin-mediated endocytosis by recruiting the 5'-lipid phosphatase SHIP2 and lamellipodin to mediate the local production of phosphatidylinositol-3,4-bisphosphate and endophilin pre-enrichment.
      Title: FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis.
    8. Results suggest that FBP17 is highly expressed in breast cancer cells and facilitates the invasion of breast cancer cells.
      Title: High expression of FBP17 in invasive breast cancer cells promotes invadopodia formation.
    9. FBP17 is the local activator of actin polymerization that is inhibited by PM tension in the feedback loop that regulates cell migration.
      Title: Feedback regulation between plasma membrane tension and membrane-bending proteins organizes cell polarity during leading edge formation.
    10. Knockdown of PSTPIP2 inmacrophages enhances the assembly of FBP17, leading to'hyperactivation' of actin nucleation at podosomes and ECM degradation.
      Title: Antagonistic regulation of F-BAR protein assemblies controls actin polymerization during podosome formation.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • KIAA0554, MGC126804

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    formin-binding protein 1
    Names
    formin-binding protein 17

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033946.2 RefSeqGene

      Range
      15690..171692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001363755.1 → NP_001350684.1  formin-binding protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AA848014, AK023681, AL158207, DA043485
      Consensus CDS
      CCDS87699.1
      UniProtKB/TrEMBL
      A0A994J4A3
      Related
      ENSP00000347907.3, ENST00000355681.3
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:378 → 454
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cl17036
      Location:524 → 579
      SH3; Src Homology 3 domain superfamily

    2. NM_001411018.1 → NP_001397947.1  formin-binding protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL136141, AL158207
      Consensus CDS
      CCDS94507.1
      UniProtKB/TrEMBL
      A0A994J3U5
      Related
      ENSP00000515359.1, ENST00000703533.1

    3. NM_015033.3 → NP_055848.1  formin-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_055848.1

      Status: REVIEWED

      Source sequence(s)
      AB011126, AL158207, AW575478, CK005680
      Consensus CDS
      CCDS48040.1
      UniProtKB/Swiss-Prot
      B7ZL12, E9PGQ4, O60301, Q3MIN8, Q5TC87, Q5TC88, Q6P658, Q7LGG2, Q96RU3, Q9H8H8, Q9NWD1
      UniProtKB/TrEMBL
      A0A994J4A3
      Related
      ENSP00000413625.1, ENST00000446176.7
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:407 → 483
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cl17036
      Location:553 → 608
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      129887187..130053879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005251834.3 → XP_005251891.1  formin-binding protein 1 isoform X33

      See identical proteins and their annotated locations for XP_005251891.1

      UniProtKB/TrEMBL
      A0A994J4A3, B7ZL14, E7EPB7
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:341 → 417
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cl17036
      Location:487 → 542
      SH3; Src Homology 3 domain superfamily

    2. XM_047423022.1 → XP_047278978.1  formin-binding protein 1 isoform X32

    3. XM_047423021.1 → XP_047278977.1  formin-binding protein 1 isoform X28

    4. XM_047423020.1 → XP_047278976.1  formin-binding protein 1 isoform X27

      Related
      ENSP00000515374.1, ENST00000703558.1

    5. XM_047423018.1 → XP_047278974.1  formin-binding protein 1 isoform X24

    6. XM_047423017.1 → XP_047278973.1  formin-binding protein 1 isoform X23

    7. XM_005251826.3 → XP_005251883.1  formin-binding protein 1 isoform X20

      See identical proteins and their annotated locations for XP_005251883.1

      UniProtKB/TrEMBL
      A0A994J4A3, B7ZL13
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:397 → 473
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cl17036
      Location:543 → 598
      SH3; Src Homology 3 domain superfamily

    8. XM_047423014.1 → XP_047278970.1  formin-binding protein 1 isoform X9

    9. XM_005251824.3 → XP_005251881.1  formin-binding protein 1 isoform X17

      See identical proteins and their annotated locations for XP_005251881.1

      UniProtKB/TrEMBL
      A0A994J4A3
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:402 → 478
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cl17036
      Location:548 → 603
      SH3; Src Homology 3 domain superfamily

    10. XM_047423016.1 → XP_047278972.1  formin-binding protein 1 isoform X16

    11. XM_047423013.1 → XP_047278969.1  formin-binding protein 1 isoform X7

    12. XM_011518402.2 → XP_011516704.1  formin-binding protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8V8TQ35, A0A994J6U4
      Related
      ENSP00000514403.1, ENST00000699492.1
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:435 → 511
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cd12071
      Location:581 → 636
      SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17

    13. XM_011518401.2 → XP_011516703.1  formin-binding protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A994J6U4
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:435 → 511
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cd12071
      Location:582 → 637
      SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17

    14. XM_017014492.3 → XP_016869981.1  formin-binding protein 1 isoform X29

      UniProtKB/TrEMBL
      A0A994J6U4

    15. XM_005251833.4 → XP_005251890.1  formin-binding protein 1 isoform X31

      UniProtKB/TrEMBL
      A0A994J4A3
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:341 → 417
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cl17036
      Location:487 → 542
      SH3; Src Homology 3 domain superfamily

    16. XM_005251831.4 → XP_005251888.1  formin-binding protein 1 isoform X30

      UniProtKB/TrEMBL
      A0A994J4A3
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:346 → 422
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cl17036
      Location:493 → 548
      SH3; Src Homology 3 domain superfamily

    17. XM_047423019.1 → XP_047278975.1  formin-binding protein 1 isoform X26

    18. XM_005251830.4 → XP_005251887.1  formin-binding protein 1 isoform X25

      UniProtKB/TrEMBL
      A0A994J4A3
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:373 → 449
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cl17036
      Location:520 → 575
      SH3; Src Homology 3 domain superfamily

    19. XM_047423015.1 → XP_047278971.1  formin-binding protein 1 isoform X15

    20. XM_006717016.4 → XP_006717079.1  formin-binding protein 1 isoform X12

      UniProtKB/TrEMBL
      A0A994J6U4
      Related
      ENSP00000515376.1, ENST00000703560.1
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:406 → 482
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cl17036
      Location:553 → 608
      SH3; Src Homology 3 domain superfamily

    21. XM_005251828.4 → XP_005251885.1  formin-binding protein 1 isoform X22

      UniProtKB/TrEMBL
      A0A994J4A3, H0Y7W6
      Related
      ENSP00000415602.3, ENST00000449089.7
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:392 → 468
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cl17036
      Location:538 → 593
      SH3; Src Homology 3 domain superfamily

    22. XM_005251827.4 → XP_005251884.1  formin-binding protein 1 isoform X21

      UniProtKB/TrEMBL
      A0A994J4A3
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:392 → 468
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cl17036
      Location:539 → 594
      SH3; Src Homology 3 domain superfamily

    23. XM_005251825.4 → XP_005251882.1  formin-binding protein 1 isoform X19

      UniProtKB/TrEMBL
      A0A994J4A3
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:397 → 473
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cl17036
      Location:543 → 598
      SH3; Src Homology 3 domain superfamily

    24. XM_017014488.3 → XP_016869977.1  formin-binding protein 1 isoform X18

      UniProtKB/TrEMBL
      A0A994J4A3

    25. XM_005251815.4 → XP_005251872.1  formin-binding protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A994J6U4
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:425 → 501
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cl17036
      Location:572 → 627
      SH3; Src Homology 3 domain superfamily

    26. XM_005251823.4 → XP_005251880.1  formin-binding protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A994J4A3
      Related
      ENSP00000515358.1, ENST00000703532.1
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:402 → 478
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cl17036
      Location:548 → 603
      SH3; Src Homology 3 domain superfamily

    27. XM_005251822.4 → XP_005251879.1  formin-binding protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A994J4A3
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:402 → 478
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cl17036
      Location:549 → 604
      SH3; Src Homology 3 domain superfamily

    28. XM_005251821.4 → XP_005251878.1  formin-binding protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A994J4A3
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:407 → 483
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cl17036
      Location:553 → 608
      SH3; Src Homology 3 domain superfamily

    29. XM_005251820.4 → XP_005251877.1  formin-binding protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A994J3V8, A0A994J4A3
      Related
      ENSP00000515375.1, ENST00000703559.1
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:407 → 483
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cl17036
      Location:554 → 609
      SH3; Src Homology 3 domain superfamily

    30. XM_047423012.1 → XP_047278968.1  formin-binding protein 1 isoform X6

    31. XM_047423011.1 → XP_047278967.1  formin-binding protein 1 isoform X4

    32. XM_011518400.4 → XP_011516702.1  formin-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A994J6U4
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:435 → 511
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cd12071
      Location:581 → 636
      SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17

    33. XM_011518399.4 → XP_011516701.1  formin-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A994J6U4
      Conserved Domains (3) summary
      cd07676
      Location:5 → 257
      F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
      cd11629
      Location:435 → 511
      HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
      cd12071
      Location:582 → 637
      SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      142091913..142247931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362428.1 → XP_054218403.1  formin-binding protein 1 isoform X33

    2. XM_054362427.1 → XP_054218402.1  formin-binding protein 1 isoform X32

    3. XM_054362424.1 → XP_054218399.1  formin-binding protein 1 isoform X28

    4. XM_054362423.1 → XP_054218398.1  formin-binding protein 1 isoform X27

    5. XM_054362420.1 → XP_054218395.1  formin-binding protein 1 isoform X24

    6. XM_054362419.1 → XP_054218394.1  formin-binding protein 1 isoform X23

    7. XM_054362416.1 → XP_054218391.1  formin-binding protein 1 isoform X20

    8. XM_054362405.1 → XP_054218380.1  formin-binding protein 1 isoform X9

    9. XM_054362413.1 → XP_054218388.1  formin-binding protein 1 isoform X17

    10. XM_054362412.1 → XP_054218387.1  formin-binding protein 1 isoform X16

    11. XM_054362403.1 → XP_054218378.1  formin-binding protein 1 isoform X7

    12. XM_054362401.1 → XP_054218376.1  formin-binding protein 1 isoform X5

    13. XM_054362399.1 → XP_054218374.1  formin-binding protein 1 isoform X3

    14. XM_054362426.1 → XP_054218401.1  formin-binding protein 1 isoform X31

    15. XM_054362425.1 → XP_054218400.1  formin-binding protein 1 isoform X30

    16. XM_054362422.1 → XP_054218397.1  formin-binding protein 1 isoform X26

    17. XM_054362421.1 → XP_054218396.1  formin-binding protein 1 isoform X25

    18. XM_054362411.1 → XP_054218386.1  formin-binding protein 1 isoform X15

    19. XM_054362408.1 → XP_054218383.1  formin-binding protein 1 isoform X12

    20. XM_054362418.1 → XP_054218393.1  formin-binding protein 1 isoform X22

    21. XM_054362417.1 → XP_054218392.1  formin-binding protein 1 isoform X21

    22. XM_054362415.1 → XP_054218390.1  formin-binding protein 1 isoform X19

    23. XM_054362414.1 → XP_054218389.1  formin-binding protein 1 isoform X18

    24. XM_054362404.1 → XP_054218379.1  formin-binding protein 1 isoform X8

    25. XM_054362410.1 → XP_054218385.1  formin-binding protein 1 isoform X14

    26. XM_054362409.1 → XP_054218384.1  formin-binding protein 1 isoform X13

    27. XM_054362407.1 → XP_054218382.1  formin-binding protein 1 isoform X11

    28. XM_054362406.1 → XP_054218381.1  formin-binding protein 1 isoform X10

    29. XM_054362402.1 → XP_054218377.1  formin-binding protein 1 isoform X6

    30. XM_054362400.1 → XP_054218375.1  formin-binding protein 1 isoform X4

    31. XM_054362398.1 → XP_054218373.1  formin-binding protein 1 isoform X2

    32. XM_054362397.1 → XP_054218372.1  formin-binding protein 1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96RU3.2 GenPept UniProtKB/Swiss-Prot:Q96RU3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous