Inhbb inhibin subunit beta B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Inhbbprovided by RGD
Official Full Name: inhibin subunit beta Bprovided by RGD
Primary source: RGD:2913
See related: Ensembl:ENSRNOG00000060237 AllianceGenome:RGD:2913
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables inhibin binding activity. Involved in several processes, including cellular response to Thyroglobulin triiodothyronine; cellular response to organic cyclic compound; and gonad development. Located in extracellular space. Part of inhibin B complex. Biomarker of congenital hypothyroidism. Orthologous to human INHBB (inhibin subunit beta B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 62.7), Uterus (RPKM 61.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (33083671..33089373, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (30530860..30536566, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (35436532..35442222, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activin B induced phosphorylation and activation of Smad1/5/8, the BMP-regulated (BR)-Smads. The stimulation of hepcidin transcription by activin B was mediated by ALK2 and ActRIIA, receptors for the TGF-beta family.
Title: Regulation of hepcidin expression by inflammation-induced activin B.
RhoA regulates Activin B-induced stress fiber formation and migration of Bone marrow-derived mesenchymal stem cells.
Title: RhoA regulates Activin B-induced stress fiber formation and migration of bone marrow-derived mesenchymal stromal cell through distinct signaling.
Results identified Inhbb as one factor mediating the proliferative effect of Pdx-1 on islet cells.
Title: A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation.
Fluorine had no effect on the expression of androgen binding protein and inhibin B mRNA in testis sertoli cells of Sprague Dawley rats.
Title: [Influence of fluorine on expression of androgen-binding protein and inhibin B mRNA in rat testis sertoli cells].
p,p'-DDE could inhibit the expression of inhibin B in rat Sertoli cells.
Title: [Effects of p,p'-DDE on expression of inhibin B in sertoli cells of rats].
TNFalpha and IL1alpha supresses inhibin B secretion and expression in rat Sertoli cells
Title: Regulation of Sertoli cell activin A and inhibin B by tumour necrosis factor α and interleukin 1α: interaction with follicle-stimulating hormone/adenosine 3',5'-cyclic phosphate signalling.
The effect of steroidogenic substrates and follicle stimulating hormone on steroid, inhibin A and B, Pro-alphaC and activin A production was evaluated.
Title: Regulation of inhibin/activin expression in rat early antral follicles.
Bacterial lipopolysaccharide increased the production of interleukin 1alpha and activin A, and reduced production of inhibin B, in Sertoli cells from immature male rats.
Title: Regulation of interleukin 1alpha, activin and inhibin by lipopolysaccharide in Sertoli cells from prepubertal rats.
propose hypothesis that increase in growth rate subsequent to weaning signals circulating inhibin B levels to fall and pituitary adenylate cyclase-activating polypeptide to decrease and these events facilitate the rise in follicle-stimulating hormone b
Title: Weaning and the developmental changes in follicle-stimulating hormone, pituitary adenylate cyclase-activating polypeptide, and inhibin B in the male rat.
Regulation of pituitary Nr5a2, Inhba, and Inhbb transcripts was limited to young animals.
Title: Anterior pituitary gene expression with reproductive aging in the female rat.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

d13mgh16 (e-PCR)
- UniSTS:120868

PMC155220P1 (e-PCR)
- UniSTS:271333

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in activin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in activin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to Thyroglobulin triiodothyronine	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cholesterol	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to leptin stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to leptin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to thyroid hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in female gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of follicle-stimulating hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of follicle-stimulating hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of follicle-stimulating hormone secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of hepatocyte growth factor production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hepatocyte growth factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hepatocyte growth factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in oocyte development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oocyte development	ISO Inferred from Sequence Orthology more info
involved_in pituitary gland development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of follicle-stimulating hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of follicle-stimulating hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of follicle-stimulating hormone secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ovulation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ovulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ovulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to gonadotropin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insecticide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to wounding	IEA Inferred from Electronic Annotation more info
involved_in response to wounding	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	ISS Inferred from Sequence or Structural Similarity more info
involved_in seminiferous tubule development	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	IEA Inferred from Electronic Annotation more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: inhibin beta B chain

Names: activin beta-B chain; activin betaB; inhibin beta B subunit; inhibin beta subunit B; inhibin beta-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080771.3 → NP_542949.1 inhibin beta B chain precursor

See identical proteins and their annotated locations for NP_542949.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P17491, Q8K471

UniProtKB/TrEMBL

A0A0G2K0C6

Related

ENSRNOP00000071390.2, ENSRNOT00000086350.2

Conserved Domains (2) summary

cd19405
Location:305 → 411

TGF_beta_INHBB; transforming growth factor beta (TGF-beta) like domain found in inhibin beta B chain (INHBB) and similar proteins

cl02928
Location:73 → 282

TGFb_propeptide; TGF-beta propeptide