Snap23 synaptosome associated protein 23 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Snap23provided by RGD
Official Full Name: synaptosome associated protein 23provided by RGD
Primary source: RGD:620221
See related: Ensembl:ENSRNOG00000050552 AllianceGenome:RGD:620221
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables SNAP receptor activity and syntaxin binding activity. Involved in several processes, including exocytic insertion of neurotransmitter receptor to postsynaptic membrane; regulation of exocytosis; and vesicle-mediated transport in synapse. Located in plasma membrane. Part of SNARE complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynapse. Orthologous to human SNAP23 (synaptosome associated protein 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 334.0), Spleen (RPKM 216.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (127966184..127999929)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (107514088..107546177)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (112333972..112362960)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SNAP23 decreases insulin secretion by competitively inhibiting the interaction between SNAP25 and STX1A.
Title: SNAP23 decreases insulin secretion by competitively inhibiting the interaction between SNAP25 and STX1A.
Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes.
Title: Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes.
PKCepsilon controls the fusion of secretory vesicles in mast cells in a phosphatidic acid-dependent mode.
Title: PKCε controls the fusion of secretory vesicles in mast cells in a phosphatidic acid-dependent mode.
Blocking dephosphorylation at serine 120 residue in SNAP-23 leads to massive inhibition in exocytosis from mast cells.
Title: Blocking dephosphorylation at Serine 120 residue in t-SNARE SNAP-23 leads to massive inhibition in exocytosis from mast cells.
Syntaxin-4 and SNAP23 act as exocytic soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) to release nerve growth factors from cultured Schwann cells.
Title: Syntaxin-4 and SNAP23 act as exocytic SNAREs to release NGF from cultured Schwann cells.
Electrostatic anchoring precedes stable membrane attachment of SNAP25 and SNAP23 to the plasma membrane.
Title: Electrostatic anchoring precedes stable membrane attachment of SNAP25/SNAP23 to the plasma membrane.
Low expression of SNAP23 in lipid rafts of vascular smooth muscle cells might be a potential cause for hypertension in spontaneously hypertensive rats.
Title: Diminished Lipid Raft SNAP23 Increases Blood Pressure by Inhibiting the Membrane Fluidity of Vascular Smooth-Muscle Cells.
SNAP23-VAMP2 interaction plays a key role in cAMP-mediated exocytosis from parotid glands.
Title: Isoproterenol stimulates transient SNAP23-VAMP2 interaction in rat parotid glands.
Annexin A7 may function in co-ordination with SNARE proteins and that protein kinase activation may be required for annexin A7 trafficking.
Title: Annexin A7 and SNAP23 interactions in alveolar type II cells and in vitro: a role for Ca(2+) and PKC.
SNAP23 and SNAP25 palmitoylation is regulated by DHHC palmitoyl transferases
Title: Palmitoylation of the SNAP25 protein family: specificity and regulation by DHHC palmitoyl transferases.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141559 (e-PCR)
- UniSTS:223553

BF386077 (e-PCR)
- UniSTS:243568

RH140008 (e-PCR)
- UniSTS:222090

RH127866 (e-PCR)
- UniSTS:211176

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	ISO Inferred from Sequence Orthology more info
enables syntaxin-1 binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within exocytosis	ISO Inferred from Sequence Orthology more info
involved_in histamine secretion by mast cell	IEA Inferred from Electronic Annotation more info
involved_in histamine secretion by mast cell	ISO Inferred from Sequence Orthology more info
involved_in membrane fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle fusion to presynaptic active zone membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle priming	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport in synapse	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated transport in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of SNARE complex	IDA Inferred from Direct Assay more info	PubMed
part_of SNARE complex	ISO Inferred from Sequence Orthology more info
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in azurophil granule	IEA Inferred from Electronic Annotation more info
located_in azurophil granule	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info
located_in specific granule	IEA Inferred from Electronic Annotation more info
located_in specific granule	ISO Inferred from Sequence Orthology more info
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex	IBA Inferred from Biological aspect of Ancestor more info
located_in terminal bouton	HDA more info	PubMed

General protein information

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Preferred Names: synaptosomal-associated protein 23

Names: SNAP-23; synaptosomal-associated protein, 23 kD; vesicle-membrane fusion protein SNAP-23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429469.1 → NP_001416398.1 synaptosomal-associated protein 23 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003
NM_001429470.1 → NP_001416399.1 synaptosomal-associated protein 23 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003
NM_022689.2 → NP_073180.1 synaptosomal-associated protein 23 isoform 1

See identical proteins and their annotated locations for NP_073180.1

Status: PROVISIONAL

Source sequence(s)

BC127494

UniProtKB/Swiss-Prot

A0JPL8, O70377

Related

ENSRNOP00000091304.1, ENSRNOT00000096953.1

Conserved Domains (3) summary

cd15884
Location:148 → 206

SNARE_SNAP23C; C-terminal SNARE motif of SNAP23

cd15895
Location:9 → 75

SNARE_SNAP23N; N-terminal SNARE motif of SNAP23

pfam00835
Location:86 → 146

SNAP-25; SNAP-25 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

127966184..127999929

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105811.2 → XP_038961739.1 synaptosomal-associated protein 23 isoform X1

UniProtKB/TrEMBL

M0R4V3

Related

ENSRNOP00000064401.3

Conserved Domains (3) summary

cd15884
Location:159 → 217

SNARE_SNAP23C; C-terminal SNARE motif of SNAP23

cd15895
Location:9 → 75

SNARE_SNAP23N; N-terminal SNARE motif of SNAP23

pfam00835
Location:100 → 157

SNAP-25; SNAP-25 family
XM_039105813.2 → XP_038961741.1 synaptosomal-associated protein 23 isoform X2

UniProtKB/Swiss-Prot

A0JPL8, O70377

Conserved Domains (3) summary

cd15884
Location:148 → 206

SNARE_SNAP23C; C-terminal SNARE motif of SNAP23

cd15895
Location:9 → 75

SNARE_SNAP23N; N-terminal SNARE motif of SNAP23

pfam00835
Location:86 → 146

SNAP-25; SNAP-25 family
XM_063284525.1 → XP_063140595.1 synaptosomal-associated protein 23 isoform X2

UniProtKB/Swiss-Prot

A0JPL8, O70377
XM_039105812.2 → XP_038961740.1 synaptosomal-associated protein 23 isoform X1

UniProtKB/TrEMBL

M0R4V3

Conserved Domains (3) summary

cd15884
Location:159 → 217

SNARE_SNAP23C; C-terminal SNARE motif of SNAP23

cd15895
Location:9 → 75

SNARE_SNAP23N; N-terminal SNARE motif of SNAP23

pfam00835
Location:100 → 157

SNAP-25; SNAP-25 family
XM_063284526.1 → XP_063140596.1 synaptosomal-associated protein 23 isoform X2

UniProtKB/Swiss-Prot

A0JPL8, O70377