Fyn FYN proto-oncogene, Src family tyrosine kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fynprovided by RGD
Official Full Name: FYN proto-oncogene, Src family tyrosine kinaseprovided by RGD
Primary source: RGD:2641
See related: Ensembl:ENSRNOG00000000596 AllianceGenome:RGD:2641
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including phosphatidylinositol 3-kinase binding activity; protein tyrosine kinase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to organonitrogen compound; negative regulation of cell death; and protein phosphorylation. Located in several cellular components, including mitochondrion; perinuclear endoplasmic reticulum; and postsynaptic density. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease and schizophrenia. Orthologous to human FYN (FYN proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 146.3), Brain (RPKM 137.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (44322635..44514498)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (42767733..42960903)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (44436354..44630316)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tyrosine kinase Fyn promotes apoptosis after intracerebral hemorrhage in rats by activating Drp1 signaling.
Title: Tyrosine kinase Fyn promotes apoptosis after intracerebral hemorrhage in rats by activating Drp1 signaling.
Linkage of Non-receptor Tyrosine Kinase Fyn to mGlu5 Receptors in Striatal Neurons in a Depression Model.
Title: Linkage of Non-receptor Tyrosine Kinase Fyn to mGlu5 Receptors in Striatal Neurons in a Depression Model.
Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorder.
Title: Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorder.
leptin-signaling pathway in the hippocampus involves NR2B and Fyn
Title: Leptin Controls Glutamatergic Synaptogenesis and NMDA-Receptor Trafficking via Fyn Kinase Regulation of NR2B.
Fyn gene silencing reduced the apoptosis of OLs through inhibiting the phosphorylation of ERK1/2 in epileptic model
Title: Fyn gene silencing reduces oligodendrocytes apoptosis through inhibiting ERK1/2 phosphorylation in epilepsy.
all data suggest that H2S can attenuate uranium-induced kidney cell apoptosis mediated by ER stress via 20S proteasome involving in Akt/GSK-3beta/Fyn-Nrf2 signaling axis.
Title: Hydrogen sulfide alleviates uranium-induced kidney cell apoptosis mediated by ER stress via 20S proteasome involving in Akt/GSK-3β/Fyn-Nrf2 signaling.
Fyn binds to mGluR1a at a consensus binding motif located in the intracellular C-terminus (CT) of mGluR1a in vitro. Active Fyn phosphorylates mGluR1a at a conserved tyrosine residue in the CT region. In cerebellar neurons and transfected HEK293T cells, Fyn-mediated tyrosine phosphorylation of mGluR1a is constitutively active and facilitates surface expression of mGluR1a and potentiates mGluR1a postreceptor signaling.
Title: An Essential Role of Fyn in the Modulation of Metabotropic Glutamate Receptor 1 in Neurons.
the BDNF-Fyn-GluN2B signaling cascade in the spinal dorsal horn may constitute a key mechanism underlying central sensitization and neuropathic pain development after peripheral nerve injury
Title: BDNF Contributes to Spinal Long-Term Potentiation and Mechanical Hypersensitivity Via Fyn-Mediated Phosphorylation of NMDA Receptor GluN2B Subunit at Tyrosine 1472 in Rats Following Spinal Nerve Ligation.
We find that BDNF mediates NMDAR potentiation through activation of TrkB and phosphorylation of the GluN2B subunit by the Src-family kinase Fyn
Title: Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing.
results indicate that D2Rs inhibit SFK (mainly Fyn) phosphorylation in the striatum
Title: Dopamine D2 receptors are involved in the regulation of Fyn and metabotropic glutamate receptor 5 phosphorylation in the rat striatum in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

FYN_1578 (e-PCR)
- UniSTS:277262

BE113818 (e-PCR)
- UniSTS:246813

RH137616 (e-PCR)
- UniSTS:219703

BF405827 (e-PCR)
- UniSTS:247968

D20RAT55 (e-PCR)
- UniSTS:121567

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CD4 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables CD8 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables T cell receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables alpha-tubulin binding	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables disordered domain specific binding	IEA Inferred from Electronic Annotation more info
enables disordered domain specific binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables ephrin receptor binding	IEA Inferred from Electronic Annotation more info
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info
enables growth factor receptor binding	IEA Inferred from Electronic Annotation more info
enables growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables peptide hormone receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatidylinositol 3-kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase activator activity	IEA Inferred from Electronic Annotation more info
enables phospholipase activator activity	ISO Inferred from Sequence Orthology more info
enables phospholipase binding	IEA Inferred from Electronic Annotation more info
enables phospholipase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables tau protein binding	IEA Inferred from Electronic Annotation more info
enables tau protein binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info
enables type 5 metabotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in activated T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to L-glutamate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amyloid-beta	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glycine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hydrogen peroxide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to peptide hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to platelet-derived growth factor stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to platelet-derived growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in dendrite morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in detection of mechanical stimulus involved in sensory perception of pain	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in forebrain development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in heart process	IEA Inferred from Electronic Annotation more info
involved_in heart process	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in ionotropic glutamate receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dendritic spine maintenance	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dendritic spine maintenance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hydrogen peroxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in regulation of calcium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in response to singlet oxygen	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in actin filament	IEA Inferred from Electronic Annotation more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in cell body	IEA Inferred from Electronic Annotation more info
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in glial cell projection	IEA Inferred from Electronic Annotation more info
located_in glial cell projection	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perinuclear endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tyrosine-protein kinase Fyn

Names: FYN oncogene related to SRC, FGR, YES; p59-Fyn; proto-oncogene c-Fyn; proto-oncogene tyrosine-protein kinase Fyn

NP_036887.1

EC 2.7.10.2

XP_006256584.1

EC 2.7.10.2

XP_017457038.2

EC 2.7.10.2

XP_038954364.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012755.2 → NP_036887.1 tyrosine-protein kinase Fyn

See identical proteins and their annotated locations for NP_036887.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

Q62844

UniProtKB/TrEMBL

A0A096MKC1

Related

ENSRNOP00000000733.1, ENSRNOT00000000733.5

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

44322635..44514498

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256522.3 → XP_006256584.1 tyrosine-protein kinase Fyn isoform X1

UniProtKB/TrEMBL

A0A096MKC1, A0A8I6A612

Related

ENSRNOP00000088889.1

Conserved Domains (4) summary

cd10418
Location:183 → 283

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:123 → 178

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:299 → 572

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

pfam07714
Location:309 → 558

Pkinase_Tyr; Protein tyrosine kinase
XM_017601549.3 → XP_017457038.2 tyrosine-protein kinase Fyn isoform X2

UniProtKB/TrEMBL

A0A096MKC1

Related

ENSRNOP00000068458.1

Conserved Domains (3) summary

cd10368
Location:183 → 283

SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn

cd12006
Location:123 → 178

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:296 → 569

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
XM_039098436.2 → XP_038954364.1 tyrosine-protein kinase Fyn isoform X3

UniProtKB/Swiss-Prot

Q62844

UniProtKB/TrEMBL

A0A096MKC1

Conserved Domains (3) summary

cd10418
Location:145 → 245

SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins

cd12006
Location:85 → 140

SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases

cd05070
Location:261 → 534

PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn