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    Map2 microtubule-associated protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25595, updated on 3-Apr-2024

    Summary

    Official Symbol
    Map2provided by RGD
    Official Full Name
    microtubule-associated protein 2provided by RGD
    Primary source
    RGD:3044
    See related
    Ensembl:ENSRNOG00000011841 AllianceGenome:RGD:3044
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MAP2R; Mtap2
    Summary
    Enables actin binding activity; microtubule binding activity; and protein kinase binding activity. Involved in several processes, including negative regulation of cellular component organization; positive regulation of vesicle transport along microtubule; and response to progesterone. Located in several cellular components, including axon; dendrite; and endoplasmic reticulum. Part of protein-containing complex. Used to study Alzheimer's disease and cerebral infarction. Biomarker of arteriovenous malformation; asphyxia neonatorum; brain ischemia; sciatic neuropathy; and temporal lobe epilepsy. Orthologous to human MAP2 (microtubule associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 797.4) and Adrenal (RPKM 83.9) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    9q32
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (75173038..75431606)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (67723422..67981886)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (73204753..73462965)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene crystallin, gamma F Neighboring gene splicing regulatory glutamic acid and lysine rich protein 1, pseudogene 1 Neighboring gene unc-80 homolog, NALCN channel complex subunit Neighboring gene KAT8 regulatory NSL complex subunit 1-like Neighboring gene ribulose-5-phosphate-3-epimerase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables dystroglycan binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables dystroglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to organic substance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in central nervous system neuron development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in central nervous system neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of anterograde dense core granule transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of anterograde synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of organelle transport along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to progesterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in CA3 pyramidal cell dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in apical dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical distal dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon hillock IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon hillock ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon initial segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon initial segment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic branch IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic shaft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in distal dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT located_in main axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear periphery ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in primary dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in proximal dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in proximal neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in proximal neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    microtubule-associated protein 2
    Names
    MAP-2
    microtubule-associated protein 2C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013066.1NP_037198.1  microtubule-associated protein 2

      See identical proteins and their annotated locations for NP_037198.1

      Status: PROVISIONAL

      Source sequence(s)
      X54100
      UniProtKB/Swiss-Prot
      P15146
      UniProtKB/TrEMBL
      Q64715
      Related
      ENSRNOP00000089734.1, ENSRNOT00000110600.1
      Conserved Domains (2) summary
      pfam00418
      Location:16901719
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:3741507
      MAP2_projctn; MAP2/Tau projection domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      75173038..75431606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266724.1XP_063122794.1  microtubule-associated protein 2 isoform X11

    2. XM_063266731.1XP_063122801.1  microtubule-associated protein 2 isoform X16

      UniProtKB/TrEMBL
      A6KFC4
    3. XM_063266715.1XP_063122785.1  microtubule-associated protein 2 isoform X8

      UniProtKB/TrEMBL
      F1MAQ5
    4. XM_063266720.1XP_063122790.1  microtubule-associated protein 2 isoform X9

    5. XM_063266734.1XP_063122804.1  microtubule-associated protein 2 isoform X20

      UniProtKB/TrEMBL
      A0A9K3Y814, E9PTL3, Q78DZ1
    6. XM_063266718.1XP_063122788.1  microtubule-associated protein 2 isoform X10

    7. XM_017596293.3XP_017451782.1  microtubule-associated protein 2 isoform X1

      UniProtKB/Swiss-Prot
      P15146
      UniProtKB/TrEMBL
      F1LNK0
      Conserved Domains (3) summary
      PTZ00449
      Location:14981772
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam08377
      Location:4601593
      MAP2_projctn; MAP2/Tau projection domain
      pfam00418
      Location:17761806
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    8. XM_063266713.1XP_063122783.1  microtubule-associated protein 2 isoform X6

    9. XM_063266707.1XP_063122777.1  microtubule-associated protein 2 isoform X3

    10. XM_063266717.1XP_063122787.1  microtubule-associated protein 2 isoform X9

    11. XM_063266708.1XP_063122778.1  microtubule-associated protein 2 isoform X4

    12. XM_063266711.1XP_063122781.1  microtubule-associated protein 2 isoform X5

    13. XM_063266726.1XP_063122796.1  microtubule-associated protein 2 isoform X12

    14. XM_039083075.2XP_038939003.1  microtubule-associated protein 2 isoform X1

      UniProtKB/Swiss-Prot
      P15146
      UniProtKB/TrEMBL
      F1LNK0
      Conserved Domains (3) summary
      PTZ00449
      Location:14981772
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam08377
      Location:4601593
      MAP2_projctn; MAP2/Tau projection domain
      pfam00418
      Location:17761806
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    15. XM_063266709.1XP_063122779.1  microtubule-associated protein 2 isoform X3

    16. XM_063266723.1XP_063122793.1  microtubule-associated protein 2 isoform X11

    17. XM_063266722.1XP_063122792.1  microtubule-associated protein 2 isoform X10

    18. XM_063266727.1XP_063122797.1  microtubule-associated protein 2 isoform X12

    19. XM_063266714.1XP_063122784.1  microtubule-associated protein 2 isoform X8

      UniProtKB/TrEMBL
      F1MAQ5
    20. XM_063266729.1XP_063122799.1  microtubule-associated protein 2 isoform X13

    21. XM_063266732.1XP_063122802.1  microtubule-associated protein 2 isoform X16

      UniProtKB/TrEMBL
      A6KFC4
    22. XM_063266735.1XP_063122805.1  microtubule-associated protein 2 isoform X20

      UniProtKB/TrEMBL
      A0A9K3Y814, E9PTL3, Q78DZ1
    23. XM_017596291.3XP_017451780.1  microtubule-associated protein 2 isoform X1

      UniProtKB/Swiss-Prot
      P15146
      UniProtKB/TrEMBL
      F1LNK0
      Conserved Domains (3) summary
      PTZ00449
      Location:14981772
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam08377
      Location:4601593
      MAP2_projctn; MAP2/Tau projection domain
      pfam00418
      Location:17761806
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    24. XM_017596297.3XP_017451786.1  microtubule-associated protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6GHK9
      Conserved Domains (2) summary
      pfam00418
      Location:17761805
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:4601593
      MAP2_projctn; MAP2/Tau projection domain
    25. XM_008767200.4XP_008765422.1  microtubule-associated protein 2 isoform X2

      UniProtKB/Swiss-Prot
      P15146
      Conserved Domains (2) summary
      pfam00418
      Location:17751804
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:4601592
      MAP2_projctn; MAP2/Tau projection domain
    26. XM_039083078.2XP_038939006.1  microtubule-associated protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I6GHK9
      Conserved Domains (3) summary
      PTZ00449
      Location:14981771
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam08377
      Location:4601592
      MAP2_projctn; MAP2/Tau projection domain
      pfam00418
      Location:18061837
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    27. XM_008767199.4XP_008765421.1  microtubule-associated protein 2 isoform X3

      UniProtKB/Swiss-Prot
      P15146
      Conserved Domains (2) summary
      pfam00418
      Location:17751804
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:4591592
      MAP2_projctn; MAP2/Tau projection domain
    28. XM_017596298.3XP_017451787.1  microtubule-associated protein 2 isoform X8

      UniProtKB/Swiss-Prot
      P15146
      UniProtKB/TrEMBL
      F1MAQ5
      Related
      ENSRNOP00000042029.6
      Conserved Domains (2) summary
      pfam00418
      Location:16941723
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:3781511
      MAP2_projctn; MAP2/Tau projection domain
    29. XM_008767206.4XP_008765428.1  microtubule-associated protein 2 isoform X13

      UniProtKB/Swiss-Prot
      P15146
      Conserved Domains (2) summary
      pfam00418
      Location:16941723
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:3781511
      MAP2_projctn; MAP2/Tau projection domain
    30. XM_063266719.1XP_063122789.1  microtubule-associated protein 2 isoform X9

    31. XM_039083083.2XP_038939011.1  microtubule-associated protein 2 isoform X14

      UniProtKB/Swiss-Prot
      P15146
      Conserved Domains (3) summary
      PTZ00449
      Location:14161689
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam08377
      Location:3781510
      MAP2_projctn; MAP2/Tau projection domain
      pfam00418
      Location:17241755
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    32. XM_008767205.4XP_008765427.1  microtubule-associated protein 2 isoform X11

      UniProtKB/Swiss-Prot
      P15146
      Conserved Domains (2) summary
      pfam00418
      Location:16901719
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam08377
      Location:3741507
      MAP2_projctn; MAP2/Tau projection domain
    33. XM_039083086.2XP_038939014.1  microtubule-associated protein 2 isoform X17

      UniProtKB/Swiss-Prot
      P15146
      Conserved Domains (3) summary
      PTZ00449
      Location:14121685
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam08377
      Location:3741506
      MAP2_projctn; MAP2/Tau projection domain
      pfam00418
      Location:17201751
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    34. XM_008767207.4XP_008765429.1  microtubule-associated protein 2 isoform X20

      See identical proteins and their annotated locations for XP_008765429.1

      UniProtKB/TrEMBL
      A0A0U1RS04, A0A9K3Y814, E9PTL3, Q78DZ1
      Related
      ENSRNOP00000031915.5
      Conserved Domains (1) summary
      pfam00418
      Location:332361
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    35. XM_008767208.4XP_008765430.1  microtubule-associated protein 2 isoform X21

      See identical proteins and their annotated locations for XP_008765430.1

      UniProtKB/TrEMBL
      A0A0U1RS04, A6KFC7
      Conserved Domains (1) summary
      pfam00418
      Location:332361
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    36. XM_039083077.2XP_038939005.1  microtubule-associated protein 2 isoform X5

      UniProtKB/Swiss-Prot
      P15146
      Conserved Domains (3) summary
      PTZ00449
      Location:14961770
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam08377
      Location:4581591
      MAP2_projctn; MAP2/Tau projection domain
      pfam00418
      Location:17741804
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    37. XM_039083081.2XP_038939009.1  microtubule-associated protein 2 isoform X10

      UniProtKB/Swiss-Prot
      P15146
      Conserved Domains (3) summary
      PTZ00449
      Location:14151689
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam08377
      Location:3771510
      MAP2_projctn; MAP2/Tau projection domain
      pfam00418
      Location:16931723
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    38. XM_039083084.2XP_038939012.1  microtubule-associated protein 2 isoform X15

      UniProtKB/Swiss-Prot
      P15146
      Conserved Domains (3) summary
      PTZ00449
      Location:14151689
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam08377
      Location:3771510
      MAP2_projctn; MAP2/Tau projection domain
      pfam00418
      Location:17241755
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    39. XM_039083082.2XP_038939010.1  microtubule-associated protein 2 isoform X12

      UniProtKB/Swiss-Prot
      P15146
      Conserved Domains (3) summary
      PTZ00449
      Location:14111685
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam08377
      Location:3731506
      MAP2_projctn; MAP2/Tau projection domain
      pfam00418
      Location:16891719
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    40. XM_039083085.2XP_038939013.1  microtubule-associated protein 2 isoform X18

      UniProtKB/Swiss-Prot
      P15146
      Conserved Domains (3) summary
      PTZ00449
      Location:14111685
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam08377
      Location:3731506
      MAP2_projctn; MAP2/Tau projection domain
      pfam00418
      Location:17201751
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    41. XM_063266733.1XP_063122803.1  microtubule-associated protein 2 isoform X19

    42. XM_063266737.1XP_063122807.1  microtubule-associated protein 2 isoform X22

    43. XM_063266710.1XP_063122780.1  microtubule-associated protein 2 isoform X3

    44. XM_063266716.1XP_063122786.1  microtubule-associated protein 2 isoform X8

      UniProtKB/TrEMBL
      F1MAQ5
    45. XM_063266730.1XP_063122800.1  microtubule-associated protein 2 isoform X13

    46. XM_063266725.1XP_063122795.1  microtubule-associated protein 2 isoform X11

    47. XM_063266736.1XP_063122806.1  microtubule-associated protein 2 isoform X20

      UniProtKB/TrEMBL
      A0A9K3Y814, E9PTL3, Q78DZ1
    48. XM_063266712.1XP_063122782.1  microtubule-associated protein 2 isoform X5

    49. XM_063266721.1XP_063122791.1  microtubule-associated protein 2 isoform X10

    50. XM_063266728.1XP_063122798.1  microtubule-associated protein 2 isoform X12