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    Cul2 cullin 2 [ Mus musculus (house mouse) ]

    Gene ID: 71745, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cul2provided by MGI
    Official Full Name
    cullin 2provided by MGI
    Primary source
    MGI:MGI:1918995
    See related
    Ensembl:ENSMUSG00000024231 AllianceGenome:MGI:1918995
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA4106; 1300003D18Rik; 4932411N15Rik
    Summary
    Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Acts upstream of or within protein catabolic process. Located in nucleolus. Part of Cul2-RING ubiquitin ligase complex. Is expressed in cervical ganglion; cervico-thoracic ganglion; dorsal root ganglion; thoracic ganglion; and trigeminal ganglion. Orthologous to human CUL2 (cullin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 8.3), CNS E18 (RPKM 7.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cul2 in Genome Data Viewer
    Location:
    18 A1; 18 2.21 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (3382970..3436700)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (3382970..3436700)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43653 Neighboring gene vomeronasal 1 receptor, 238 Neighboring gene STARR-seq mESC enhancer starr_43654 Neighboring gene STARR-seq mESC enhancer starr_43655 Neighboring gene STARR-positive B cell enhancer ABC_E5646 Neighboring gene cAMP responsive element modulator Neighboring gene predicted gene 6225 Neighboring gene STARR-seq mESC enhancer starr_43658 Neighboring gene profilin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43660 Neighboring gene STARR-positive B cell enhancer ABC_E10980 Neighboring gene BMP and activin membrane-bound inhibitor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Post-translational control of beige fat biogenesis by PRDM16 stabilization. Wang Q, et al. Nature, 2022 Sep. PMID 35978186, Free PMC Article
    2. Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responses. Curtis VF, et al. FASEB J, 2015 Jan. PMID 25326537, Free PMC Article
    3. ZSWIM8 is a myogenic protein that partly prevents C2C12 differentiation. Okumura F, et al. Sci Rep, 2021 Oct 22. PMID 34686700, Free PMC Article
    4. TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation. Shiraishi S, et al. J Biol Chem, 2007 Mar 23. PMID 17242400
    5. Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Zheng N, et al. Nature, 2002 Apr 18. PMID 11961546

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4106

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin ligase complex scaffold activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul2-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Cul2-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of VCB complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cullin-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cullin-2
    Names
    CUL-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360829.1 → NP_001347758.1  cullin-2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124336
      Consensus CDS
      CCDS29032.2
      UniProtKB/Swiss-Prot
      Q3TUR8, Q9D4H8
      UniProtKB/TrEMBL
      Q571A2
      Related
      ENSMUSP00000025073.6, ENSMUST00000025073.12
      Conserved Domains (2) summary
      pfam00888
      Location:14 → 644
      Cullin; Cullin family
      pfam10557
      Location:677 → 735
      Cullin_Nedd8; Cullin protein neddylation domain

    2. NM_029402.3 → NP_083678.2  cullin-2

      See identical proteins and their annotated locations for NP_083678.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124336, AK004875, AK144693, AK162910
      Consensus CDS
      CCDS29032.2
      UniProtKB/Swiss-Prot
      Q3TUR8, Q9D4H8
      UniProtKB/TrEMBL
      Q571A2
      Related
      ENSMUSP00000125403.2, ENSMUST00000162301.8
      Conserved Domains (2) summary
      pfam00888
      Location:14 → 644
      Cullin; Cullin family
      pfam10557
      Location:677 → 735
      Cullin_Nedd8; Cullin protein neddylation domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      3382970..3436700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526275.5 → XP_006526338.1  cullin-2 isoform X1

      See identical proteins and their annotated locations for XP_006526338.1

      UniProtKB/Swiss-Prot
      Q3TUR8, Q9D4H8
      UniProtKB/TrEMBL
      Q571A2
      Conserved Domains (2) summary
      pfam00888
      Location:14 → 644
      Cullin; Cullin family
      pfam10557
      Location:677 → 735
      Cullin_Nedd8; Cullin protein neddylation domain

    2. XM_030250610.2 → XP_030106470.1  cullin-2 isoform X1

      UniProtKB/Swiss-Prot
      Q3TUR8, Q9D4H8
      UniProtKB/TrEMBL
      Q571A2
      Conserved Domains (2) summary
      pfam00888
      Location:14 → 644
      Cullin; Cullin family
      pfam10557
      Location:677 → 735
      Cullin_Nedd8; Cullin protein neddylation domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D4H8.2 GenPept UniProtKB/Swiss-Prot:Q9D4H8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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