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    TRIM60 tripartite motif containing 60 [ Homo sapiens (human) ]

    Gene ID: 166655, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TRIM60provided by HGNC
    Official Full Name
    tripartite motif containing 60provided by HGNC
    Primary source
    HGNC:HGNC:21162
    See related
    Ensembl:ENSG00000176979 MIM:619416; AllianceGenome:HGNC:21162
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF33; RNF129
    Summary
    The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Pseudogenes of this gene are located on more than six chromosomes including chromosome 4. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    4q32.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (165031999..165041749)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (168379481..168389231)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (165953151..165962901)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 75 pseudogene Neighboring gene tripartite motif-containing 75 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:165952653-165953309 Neighboring gene tripartite motif containing 75 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:165990521-165991020 Neighboring gene transmembrane protein 192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22115 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15782 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:166033986-166034184

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-κB activation and the innate immune response. Gu Z, et al. Cell Mol Immunol, 2021 Aug. PMID 33184450, Free PMC Article
    2. Does this have a familiar RING? Saurin AJ, et al. Trends Biochem Sci, 1996 Jun. PMID 8744354
    3. Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3η as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability. Silva LE, et al. J Proteome Res, 2019 Oct 4. PMID 31478661
    4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Trynka G, et al. Gut, 2009 Aug. PMID 19240061
    5. POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1. Wang B, et al. EBioMedicine, 2019 Mar. PMID 30745168, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ35882, MGC119325

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SUMO-ubiquitin ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of non-canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 60
    Names
    ring finger protein 129
    ring finger protein 33

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001258025.2 → NP_001244954.1  tripartite motif-containing protein 60

      See identical proteins and their annotated locations for NP_001244954.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC106872, BC100986
      Consensus CDS
      CCDS3808.1
      UniProtKB/Swiss-Prot
      Q495X7, Q8NA35
      Related
      ENSP00000426496.1, ENST00000508504.1
      Conserved Domains (5) summary
      cd15828
      Location:286 → 465
      SPRY_PRY_TRIM60; PRY/SPRY domain of tripartite motif-binding protein 60 (TRIM60) also known as RING finger protein 33 (RNF33)
      pfam00643
      Location:92 → 133
      zf-B_box; B-box zinc finger
      pfam15905
      Location:139 → 260
      HMMR_N; Hyaluronan mediated motility receptor N-terminal
      cd16607
      Location:13 → 59
      RING-HC_TRIM60_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM60, TRIM61 and similar proteins
      cl26688
      Location:16 → 105
      DWNN; DWNN domain

    2. NM_152620.3 → NP_689833.1  tripartite motif-containing protein 60

      See identical proteins and their annotated locations for NP_689833.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC106872, AK093201
      Consensus CDS
      CCDS3808.1
      UniProtKB/Swiss-Prot
      Q495X7, Q8NA35
      Related
      ENSP00000421142.1, ENST00000512596.6
      Conserved Domains (5) summary
      cd15828
      Location:286 → 465
      SPRY_PRY_TRIM60; PRY/SPRY domain of tripartite motif-binding protein 60 (TRIM60) also known as RING finger protein 33 (RNF33)
      pfam00643
      Location:92 → 133
      zf-B_box; B-box zinc finger
      pfam15905
      Location:139 → 260
      HMMR_N; Hyaluronan mediated motility receptor N-terminal
      cd16607
      Location:13 → 59
      RING-HC_TRIM60_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM60, TRIM61 and similar proteins
      cl26688
      Location:16 → 105
      DWNN; DWNN domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      165031999..165041749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531683.3 → XP_011529985.1  tripartite motif-containing protein 60 isoform X1

      See identical proteins and their annotated locations for XP_011529985.1

      UniProtKB/Swiss-Prot
      Q495X7, Q8NA35
      Conserved Domains (5) summary
      cd15828
      Location:286 → 465
      SPRY_PRY_TRIM60; PRY/SPRY domain of tripartite motif-binding protein 60 (TRIM60) also known as RING finger protein 33 (RNF33)
      pfam00643
      Location:92 → 133
      zf-B_box; B-box zinc finger
      pfam15905
      Location:139 → 260
      HMMR_N; Hyaluronan mediated motility receptor N-terminal
      cd16607
      Location:13 → 59
      RING-HC_TRIM60_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM60, TRIM61 and similar proteins
      cl26688
      Location:16 → 105
      DWNN; DWNN domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      168379481..168389231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349100.1 → XP_054205075.1  tripartite motif-containing protein 60 isoform X1

      UniProtKB/Swiss-Prot
      Q495X7, Q8NA35
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q495X7.2 GenPept UniProtKB/Swiss-Prot:Q495X7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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