Cdk2ap2 cyclin dependent kinase 2 associated protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdk2ap2provided by MGI
Official Full Name: cyclin dependent kinase 2 associated protein 2provided by MGI
Primary source: MGI:MGI:1098779
See related: Ensembl:ENSMUSG00000024856 AllianceGenome:MGI:1098779
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Doc-1r; D19Ertd144e; 5830466O21Rik
Summary: Involved in regulation of microtubule cytoskeleton organization and regulation of stem cell division. Located in cytoplasm; microtubule; and nucleus. Orthologous to human CDK2AP2 (cyclin dependent kinase 2 associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in duodenum adult (RPKM 135.5), adrenal adult (RPKM 120.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 3.8 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (4146204..4149019)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (4096206..4099019)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cdk2ap2 under normal conditions has a biphasic expression, suggesting regulatory roles in early-versus-late stem cell differentiation.
Title: Cdk2ap2 is a novel regulator for self-renewal of murine embryonic stem cells.
cyclin-dependent kinase 2-associated protein 1 (CDK2AP1), an essential gene for early embryonic development, plays a role in pluripotency of ESC by engaging MBD3 to the promoter region of Wnt signaling genes
Title: A novel regulatory factor recruits the nucleosome remodeling complex to wingless integrated (Wnt) signaling gene promoters in mouse embryonic stem cells.
identified a mitogen-activated protein kinase partner, DOC1R, a murine homologue of a potential human tumor suppressor gene; characterized DOC1R during mouse oocyte meiosis resumption
Title: DOC1R: a MAP kinase substrate that control microtubule organization of metaphase II mouse oocytes.
Mouse DOC-1R gene can significantly inhibit cell growth and colony formation capacity.
Title: [Construction and expression of mouse DOC-1R antisense gene vector].

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NuRD complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cyclin-dependent kinase 2-associated protein 2

Names: CDK2-associated protein 2; DOC-1 related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026373.4 → NP_080649.1 cyclin-dependent kinase 2-associated protein 2

See identical proteins and their annotated locations for NP_080649.1

Status: VALIDATED

Source sequence(s)

AC109138

Consensus CDS

CCDS29414.1

UniProtKB/Swiss-Prot

Q9CPY4

UniProtKB/TrEMBL

G3UYI1

Related

ENSMUSP00000025779.5, ENSMUST00000025779.11

Conserved Domains (2) summary

TIGR00601
Location:5 → 107

rad23; UV excision repair protein Rad23

pfam09806
Location:63 → 126

CDK2AP; Cyclin-dependent kinase 2-associated protein