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    Zfr zinc finger RNA binding protein [ Mus musculus (house mouse) ]

    Gene ID: 22763, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfrprovided by MGI
    Official Full Name
    zinc finger RNA binding proteinprovided by MGI
    Primary source
    MGI:MGI:1341890
    See related
    Ensembl:ENSMUSG00000022201 AllianceGenome:MGI:1341890
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C920030H05Rik
    Summary
    Predicted to enable double-stranded RNA binding activity and single-stranded RNA binding activity. Predicted to be located in chromosome; cytoplasm; and nucleus. Is expressed in several structures, including early conceptus; genitourinary system; nervous system; submandibular gland primordium; and vibrissa. Orthologous to human ZFR (zinc finger RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 32.5), cortex adult (RPKM 29.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 A1; 15 5.9 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (12117649..12185535)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (12117563..12185449)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38007 Neighboring gene predicted gene 2559 Neighboring gene predicted gene, 34759 Neighboring gene microRNA 1898 Neighboring gene predicted gene 2573 Neighboring gene STARR-positive B cell enhancer ABC_E2438 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene myotubularin related protein 12 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:12160369-12160618

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Requirement for the murine zinc finger protein ZFR in perigastrulation growth and survival. Meagher MJ, et al. Mol Cell Biol, 2001 Apr. PMID 11283266, Free PMC Article
    2. ZFR promotes cell proliferation and tumor development in colorectal and liver cancers. Long Y, et al. Biochem Biophys Res Commun, 2019 Jun 11. PMID 31010678
    3. Early developmental expression of Mus musculus zinc finger RNA-binding protein compared to orthologs in Caenorhabditis elegans and Danio rerio and subcellular localization of Mus musculus and Caenorhabditis elegans zinc finger RNA-binding protein in 2-cell Mus musculus embryos. Doğanlı C, et al. DNA Cell Biol, 2010 Dec. PMID 21091219
    4. Cloning and expression of the human single copy homologue of the mouse zinc finger protein zfr. Kleines M, et al. Gene, 2001 Sep 5. PMID 11574164
    5. Identification of ZFR, an ancient and highly conserved murine chromosome-associated zinc finger protein. Meagher MJ, et al. Gene, 1999 Mar 4. PMID 10072773

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZFR overexpression also promoted tumor development of immortalized mouse liver cells.
      Title: ZFR promotes cell proliferation and tumor development in colorectal and liver cancers.
    2. Mouse Zfr mRNA was detected in all stages tested during mouse preimplantation, with higher levels at the 1-cell stage that includes the maternal contribution of Zfr mRNA.
      Title: Early developmental expression of Mus musculus zinc finger RNA-binding protein compared to orthologs in Caenorhabditis elegans and Danio rerio and subcellular localization of Mus musculus and Caenorhabditis elegans zinc finger RNA-binding protein in 2-cell Mus musculus embryos.
    3. ZFR is a native component of Staufen2-containing granules and likely plays its role during early steps of RNA transport and localization
      Title: The zinc-finger protein ZFR is critical for Staufen 2 isoform specific nucleocytoplasmic shuttling in neurons.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC176100

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger RNA-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358823.1 → NP_001345752.1  zinc finger RNA-binding protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC161269
      UniProtKB/TrEMBL
      B2RUG7
      Conserved Domains (3) summary
      smart00572
      Location:720 → 974
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      smart00451
      Location:517 → 548
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:520 → 542
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_011767.2 → NP_035897.2  zinc finger RNA-binding protein isoform 1

      See identical proteins and their annotated locations for NP_035897.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AF071059, AK034963, AK041429, BC058570, BU757317
      Consensus CDS
      CCDS37044.2
      UniProtKB/Swiss-Prot
      O88532, Q3TY30, Q8BS85, Q8CGG5, Q91VZ0, Q9CT34
      UniProtKB/TrEMBL
      B2RUG7
      Related
      ENSMUSP00000118911.2, ENSMUST00000122941.8
      Conserved Domains (4) summary
      smart00572
      Location:784 → 1038
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      PHA03255
      Location:382 → 551
      PHA03255; BDLF3; Provisional
      smart00451
      Location:581 → 612
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:584 → 606
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      12117649..12185535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520057.2 → XP_006520120.1  zinc finger RNA-binding protein isoform X1

      UniProtKB/TrEMBL
      B2RUG7
      Conserved Domains (4) summary
      smart00572
      Location:792 → 1046
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      PHA03255
      Location:390 → 559
      PHA03255; BDLF3; Provisional
      smart00451
      Location:589 → 620
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:341 → 363
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_006520059.3 → XP_006520122.1  zinc finger RNA-binding protein isoform X5

      UniProtKB/TrEMBL
      B2RUG7
      Conserved Domains (3) summary
      smart00572
      Location:728 → 982
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      smart00451
      Location:525 → 556
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:528 → 550
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_030248530.1 → XP_030104390.1  zinc finger RNA-binding protein isoform X3

      UniProtKB/TrEMBL
      B2RUG7
      Conserved Domains (4) summary
      smart00572
      Location:772 → 1026
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      PHA03255
      Location:370 → 539
      PHA03255; BDLF3; Provisional
      smart00451
      Location:569 → 600
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:321 → 343
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_036159388.1 → XP_036015281.1  zinc finger RNA-binding protein isoform X6

      UniProtKB/TrEMBL
      B2RUG7
      Conserved Domains (3) summary
      smart00572
      Location:708 → 962
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      smart00451
      Location:505 → 536
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:508 → 530
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_006520058.4 → XP_006520121.1  zinc finger RNA-binding protein isoform X2

      UniProtKB/TrEMBL
      B2RUG7
      Conserved Domains (4) summary
      smart00572
      Location:780 → 1034
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      PHA03255
      Location:378 → 547
      PHA03255; BDLF3; Provisional
      smart00451
      Location:577 → 608
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:329 → 351
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_017316588.1 → XP_017172077.1  zinc finger RNA-binding protein isoform X4

      UniProtKB/TrEMBL
      B2RUG7
      Conserved Domains (4) summary
      smart00572
      Location:740 → 994
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      PHA03255
      Location:338 → 507
      PHA03255; BDLF3; Provisional
      smart00451
      Location:537 → 568
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:289 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. XR_001781521.2 RNA Sequence

    2. XR_001781520.3 RNA Sequence

    3. XR_001781522.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88532.2 GenPept UniProtKB/Swiss-Prot:O88532

    Gene LinkOut

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