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    Angel2 angel homolog 2 [ Mus musculus (house mouse) ]

    Gene ID: 52477, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Angel2provided by MGI
    Official Full Name
    angel homolog 2provided by MGI
    Primary source
    MGI:MGI:1196310
    See related
    Ensembl:ENSMUSG00000026634 AllianceGenome:MGI:1196310
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D1Ertd396e; D1Ertd654e; 2610307I21Rik; 5730410O10Rik
    Summary
    Predicted to enable 3'-5'-exoribonuclease activity and mRNA 3'-UTR binding activity. Predicted to be involved in 3'-UTR-mediated mRNA stabilization and negative regulation of mitotic cell cycle. Predicted to be located in Cajal body and cytoplasm. Orthologous to human ANGEL2 (angel homolog 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 13.5), CNS E18 (RPKM 13.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 H6; 1 96.28 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (190657305..190679160)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (190925108..190946963)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39738 Neighboring gene ribosomal protein S6 kinase polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_03421 Neighboring gene predicted gene, 51740 Neighboring gene STARR-positive B cell enhancer mm9_chr1:192705345-192705646 Neighboring gene STARR-positive B cell enhancer ABC_E3353 Neighboring gene predicted gene, 53493 Neighboring gene vasohibin 2 Neighboring gene predicted gene, 31373

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse centromere protein F (Cenpf) gene maps to the distal region of chromosome 1 by interspecific backcross analysis. Fowler KJ, et al. Cytogenet Cell Genet, 1998. PMID 9858811
    2. ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing. Clemente P, et al. Nat Commun, 2022 Sep 30. PMID 36180430, Free PMC Article
    3. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing.
      Title: ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 3'-UTR-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein angel homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199020.1 → NP_001185949.1  protein angel homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_001185949.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region which results in the use of an in-frame downstream translation initiation site, compared to variant 1. It encodes an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC112675, AK135709, CJ081516
      Consensus CDS
      CCDS56667.1
      UniProtKB/Swiss-Prot
      Q8K1C0
      Related
      ENSMUSP00000027947.7, ENSMUST00000027947.13
      Conserved Domains (1) summary
      cl00490
      Location:147 → 520
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    2. NM_001357131.1 → NP_001344060.1  protein angel homolog 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC112675
      Consensus CDS
      CCDS56667.1
      Related
      ENSMUSP00000106524.2, ENSMUST00000110899.7
      Conserved Domains (1) summary
      cl00490
      Location:147 → 520
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    3. NM_001357132.1 → NP_001344061.1  protein angel homolog 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC112675
      Conserved Domains (1) summary
      cl00490
      Location:1 → 373
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    4. NM_001357133.1 → NP_001344062.1  protein angel homolog 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC112675
      Consensus CDS
      CCDS56667.1
      Related
      ENSMUST00000144693.2
      Conserved Domains (1) summary
      cl00490
      Location:147 → 520
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    5. NM_001357134.1 → NP_001344063.1  protein angel homolog 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC112675
      Conserved Domains (1) summary
      cl00490
      Location:1 → 373
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    6. NM_021421.4 → NP_067396.3  protein angel homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_067396.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC112675, AK158731
      Consensus CDS
      CCDS15612.1
      UniProtKB/Swiss-Prot
      Q3TEH1, Q3TL94, Q8BTT0, Q8K1C0, Q9JJB0
      Related
      ENSMUSP00000064556.8, ENSMUST00000066632.14
      Conserved Domains (1) summary
      cl00490
      Location:169 → 542
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    RNA

    1. NR_151630.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC112675
      Related
      ENSMUST00000123384.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      190657305..190679160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255505.2 → XP_030111365.1  protein angel homolog 2 isoform X3

      Conserved Domains (1) summary
      cl00490
      Location:8 → 298
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    2. XM_030255501.2 → XP_030111361.1  protein angel homolog 2 isoform X2

      Conserved Domains (1) summary
      cl00490
      Location:43 → 416
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    3. XM_017321690.3 → XP_017177179.1  protein angel homolog 2 isoform X3

      Conserved Domains (1) summary
      cl00490
      Location:8 → 298
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    4. XM_036152389.1 → XP_036008282.1  protein angel homolog 2 isoform X3

      Conserved Domains (1) summary
      cl00490
      Location:8 → 298
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    5. XM_006497186.3 → XP_006497249.1  protein angel homolog 2 isoform X2

      Conserved Domains (1) summary
      cl00490
      Location:43 → 416
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    6. XM_006497184.5 → XP_006497247.1  protein angel homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_006497247.1

      UniProtKB/Swiss-Prot
      Q8K1C0
      Conserved Domains (1) summary
      cl00490
      Location:147 → 520
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    7. XM_030255504.2 → XP_030111364.1  protein angel homolog 2 isoform X2

      Conserved Domains (1) summary
      cl00490
      Location:43 → 416
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    8. XM_006497183.5 → XP_006497246.1  protein angel homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_006497246.1

      UniProtKB/Swiss-Prot
      Q8K1C0
      Conserved Domains (1) summary
      cl00490
      Location:147 → 520
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    9. XM_030255506.2 → XP_030111366.1  protein angel homolog 2 isoform X3

      Conserved Domains (1) summary
      cl00490
      Location:8 → 298
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    RNA

    1. XR_373773.1 RNA Sequence

    2. XR_003956236.2 RNA Sequence

    3. XR_003956234.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K1C0.1 GenPept UniProtKB/Swiss-Prot:Q8K1C0

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