SULF1 sulfatase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SULF1provided by HGNC
Official Full Name: sulfatase 1provided by HGNC
Primary source: HGNC:HGNC:20391
See related: Ensembl:ENSG00000137573 MIM:610012; AllianceGenome:HGNC:20391
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SULF-1
Summary: This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression: Broad expression in urinary bladder (RPKM 23.6), prostate (RPKM 21.2) and 19 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q13.2-q13.3

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (69466781..69660912)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (69896604..70090566)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (70379016..70573147)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression.
Title: EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression.
Rs3802278 in 3'-UTR of SULF1 associated with platinum resistance and survival in Chinese epithelial ovarian cancer patients.
Title: Rs3802278 in 3'-UTR of SULF1 associated with platinum resistance and survival in Chinese epithelial ovarian cancer patients.
LncRNA NEAT1 regulated cell proliferation, invasion, migration and apoptosis by targeting has-miR-376b-3p/SULF1 axis in non-small cell lung cancer.
Title: LncRNA NEAT1 regulated cell proliferation, invasion, migration and apoptosis by targeting has-miR-376b-3p/SULF1 axis in non-small cell lung cancer.
HSulf1 and palbociclib exert synergistic antitumor effects on RBpositive triplenegative breast cancer.
Title: HSulf‑1 and palbociclib exert synergistic antitumor effects on RB‑positive triple‑negative breast cancer.
Upregulated sulfatase and downregulated MMP-3 in thoracic aortic aneurysm.
Title: Upregulated sulfatase and downregulated MMP-3 in thoracic aortic aneurysm.
our study highlights that upregulation of SULF-1 in SKOV3 cells inhibits cell proliferation, migration, and invasion in vitro and decreases lymph node metastasis in vivo.
Title: Upregulation of sulfatase-1 decreases metastatic potential of SKOV3 human ovarian cancer cells in vitro and in vivo.
Sulf-1 might play a critical role from development to maintenance of intervertebral disc homeostasis by regulating collagen expression
Title: Role of heparan sulfate 6-0 endosulfatases in intervertebral disc homeostasis.
SULF1 is highly expressed and positively correlated with poor prognosis in colon cancer.
Title: [Bioinformatical analysis of correlation between sulfatase-1 (SULF1) and prognosis of colon cancer and underlying mechanisms].
the catch bond interaction between the hydrophilic domain of the human cell surface sulfatase 1 (Sulf1HD) and its physiological substrate heparan sulfate, was investigated.
Title: Exploring the Sulfatase 1 Catch Bond Free Energy Landscape using Jarzynski's Equality.
Sulf1 is a potential up-regulatory factor in anti-hypertensive actions of CCL5 via AT2 R pathway on Ang II-induced hypertensive effects in SHR VSMCs.
Title: Sulfatase 1 mediates the attenuation of Ang II-induced hypertensive effects by CCL5 in vascular smooth muscle cells from spontaneously hypertensive rats.

Submit: New GeneRIF Correction See all GeneRIFs (61)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. EBI GWAS Catalog EBI GWAS CatalogPubMed
Wnt signaling and Dupuytren's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S1059 (e-PCR)
- UniSTS:149868

RH121420 (e-PCR)
- UniSTS:133774

RH98994 (e-PCR)
- UniSTS:89243

SHGC-83020 (e-PCR)
- UniSTS:101284

RH47887 (e-PCR)
- UniSTS:48570

SHGC-81126 (e-PCR)
- UniSTS:102344

SHGC-154482 (e-PCR)
- UniSTS:178121

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables N-acetylglucosamine-6-sulfatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetylglucosamine-6-sulfatase activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acetylglucosamine-6-sulfatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables arylsulfatase activity	IDA Inferred from Direct Assay more info	PubMed
enables arylsulfatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables glycosaminoglycan binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in bone development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cartilage development	ISS Inferred from Sequence or Structural Similarity more info
involved_in chondrocyte development	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic skeletal system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in esophagus smooth muscle contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in glial cell-derived neurotrophic factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in glomerular basement membrane development	IBA Inferred from Biological aspect of Ancestor more info
involved_in glomerular basement membrane development	ISS Inferred from Sequence or Structural Similarity more info
involved_in glomerular filtration	ISS Inferred from Sequence or Structural Similarity more info
involved_in heparan sulfate proteoglycan metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heparan sulfate proteoglycan metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in heparan sulfate proteoglycan metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in innervation	ISS Inferred from Sequence or Structural Similarity more info
involved_in kidney development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of prostatic bud formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vascular endothelial growth factor production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vascular endothelial growth factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi stack	IEA Inferred from Electronic Annotation more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	HDA more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	NAS Non-traceable Author Statement more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: extracellular sulfatase Sulf-1

Names: N-acetylglucosamine-6-sulfatase; arylsulfatase; sulfatase FP

NP_001121676.1

EC 3.1.6.1

EC 3.1.6.14

NP_001121677.1

EC 3.1.6.1

EC 3.1.6.14

NP_001121678.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399757.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399758.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399759.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399760.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399761.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399762.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399763.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399764.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399765.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399766.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399767.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399768.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399769.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399770.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399771.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399773.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399774.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399775.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399776.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399777.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399778.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399779.1

EC 3.1.6.1

EC 3.1.6.14

NP_001399780.1

EC 3.1.6.1

EC 3.1.6.14

NP_055985.2

EC 3.1.6.1

EC 3.1.6.14

XP_006716504.1

EC 3.1.6.1

EC 3.1.6.14

XP_006716505.1

EC 3.1.6.1

EC 3.1.6.14

XP_054216147.1

EC 3.1.6.1

EC 3.1.6.14

XP_054216148.1

EC 3.1.6.1

EC 3.1.6.14

XP_054216149.1

EC 3.1.6.1

EC 3.1.6.14

XP_054216150.1

EC 3.1.6.1

EC 3.1.6.14

XP_054216151.1

EC 3.1.6.1

EC 3.1.6.14

XP_054216152.1

EC 3.1.6.1

EC 3.1.6.14

XP_054216153.1

EC 3.1.6.1

EC 3.1.6.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_042849.1 RefSeqGene

Range

31224..199289

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001128204.2 → NP_001121676.1 extracellular sulfatase Sulf-1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001121676.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.

Source sequence(s)

AF545571, AK095341, AY101175

Consensus CDS

CCDS6204.1

UniProtKB/Swiss-Prot

Q86YV8, Q8IWU6, Q8NCA2, Q9UPS5

UniProtKB/TrEMBL

Q7Z2W2

Related

ENSP00000403040.2, ENST00000458141.6

Conserved Domains (3) summary

cd16147
Location:42 → 384

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:534 → 677

DUF3740; Sulfatase protein

cl23718
Location:768 → 817

ALP_like; alkaline phosphatases and sulfatases
NM_001128205.2 → NP_001121677.1 extracellular sulfatase Sulf-1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001121677.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.

Source sequence(s)

AF545571, AY101175, DA234578

Consensus CDS

CCDS6204.1

UniProtKB/Swiss-Prot

Q86YV8, Q8IWU6, Q8NCA2, Q9UPS5

UniProtKB/TrEMBL

Q7Z2W2

Related

ENSP00000385704.4, ENST00000402687.9

Conserved Domains (3) summary

cd16147
Location:42 → 384

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:534 → 677

DUF3740; Sulfatase protein

cl23718
Location:768 → 817

ALP_like; alkaline phosphatases and sulfatases
NM_001128206.2 → NP_001121678.1 extracellular sulfatase Sulf-1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001121678.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.

Source sequence(s)

AF545571, AY101175

Consensus CDS

CCDS6204.1

UniProtKB/Swiss-Prot

Q86YV8, Q8IWU6, Q8NCA2, Q9UPS5

UniProtKB/TrEMBL

Q7Z2W2

Related

ENSP00000390315.3, ENST00000419716.7

Conserved Domains (3) summary

cd16147
Location:42 → 384

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:534 → 677

DUF3740; Sulfatase protein

cl23718
Location:768 → 817

ALP_like; alkaline phosphatases and sulfatases
NM_001412828.1 → NP_001399757.1 extracellular sulfatase Sulf-1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC013746, AC022790, AC091047
NM_001412829.1 → NP_001399758.1 extracellular sulfatase Sulf-1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC013746, AC022790, AC091047
NM_001412830.1 → NP_001399759.1 extracellular sulfatase Sulf-1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC013746, AC091047
NM_001412831.1 → NP_001399760.1 extracellular sulfatase Sulf-1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC013746, AC091047
NM_001412832.1 → NP_001399761.1 extracellular sulfatase Sulf-1 isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC013746, AC022790, AC091047
NM_001412833.1 → NP_001399762.1 extracellular sulfatase Sulf-1 isoform 4 precursor

Status: REVIEWED

Source sequence(s)

AC013746, AC022790, AC091047
NM_001412834.1 → NP_001399763.1 extracellular sulfatase Sulf-1 isoform 4 precursor

Status: REVIEWED

Source sequence(s)

AC013746, AC022790, AC091047
NM_001412835.1 → NP_001399764.1 extracellular sulfatase Sulf-1 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AC013746, AC022790, AC091047

UniProtKB/Swiss-Prot

Q86YV8, Q8IWU6, Q8NCA2, Q9UPS5
NM_001412836.1 → NP_001399765.1 extracellular sulfatase Sulf-1 isoform 5 precursor

Status: REVIEWED

Source sequence(s)

AC013746, AC022790, AC091047
NM_001412837.1 → NP_001399766.1 extracellular sulfatase Sulf-1 isoform 5 precursor

Status: REVIEWED

Source sequence(s)

AC013746, AC022790, AC091047
NM_001412838.1 → NP_001399767.1 extracellular sulfatase Sulf-1 isoform 6 precursor

Status: REVIEWED

Source sequence(s)

AC013746, AC022790, AC091047
NM_001412839.1 → NP_001399768.1 extracellular sulfatase Sulf-1 isoform 6 precursor

Status: REVIEWED

Source sequence(s)

AC013746, AC022790, AC091047
NM_001412840.1 → NP_001399769.1 extracellular sulfatase Sulf-1 isoform 6 precursor

Status: REVIEWED

Source sequence(s)

AC013746, AC091047
NM_001412841.1 → NP_001399770.1 extracellular sulfatase Sulf-1 isoform 7

Status: REVIEWED

Source sequence(s)

AC013746, AC022790, AC091047
NM_001412842.1 → NP_001399771.1 extracellular sulfatase Sulf-1 isoform 7

Status: REVIEWED

Source sequence(s)

AC013746, AC091047
NM_001412844.1 → NP_001399773.1 extracellular sulfatase Sulf-1 isoform 9

Status: REVIEWED

Source sequence(s)

AC013746, AC022790, AC091047
NM_001412845.1 → NP_001399774.1 extracellular sulfatase Sulf-1 isoform 9

Status: REVIEWED

Source sequence(s)

AC013746, AC022790, AC091047

Related

ENSP00000480454.1, ENST00000616868.1
NM_001412846.1 → NP_001399775.1 extracellular sulfatase Sulf-1 isoform 10

Status: REVIEWED

Source sequence(s)

AC013746, AC022790, AC091047
NM_001412847.1 → NP_001399776.1 extracellular sulfatase Sulf-1 isoform 11 precursor

Status: REVIEWED

Source sequence(s)

AC013746
NM_001412848.1 → NP_001399777.1 extracellular sulfatase Sulf-1 isoform 11 precursor

Status: REVIEWED

Source sequence(s)

AC013746
NM_001412849.1 → NP_001399778.1 extracellular sulfatase Sulf-1 isoform 11 precursor

Status: REVIEWED

Source sequence(s)

AC013746, AC022790
NM_001412850.1 → NP_001399779.1 extracellular sulfatase Sulf-1 isoform 7 precursor

Status: REVIEWED

Source sequence(s)

AC013746, AC022790, AC091047
NM_001412851.1 → NP_001399780.1 extracellular sulfatase Sulf-1 isoform 7 precursor

Status: REVIEWED

Source sequence(s)

AC013746, AC022790, AC091047
NM_015170.3 → NP_055985.2 extracellular sulfatase Sulf-1 isoform 1 precursor

See identical proteins and their annotated locations for NP_055985.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.

Source sequence(s)

AF545571, AY101175, DA745191

Consensus CDS

CCDS6204.1

UniProtKB/Swiss-Prot

Q86YV8, Q8IWU6, Q8NCA2, Q9UPS5

UniProtKB/TrEMBL

Q7Z2W2

Related

ENSP00000260128.4, ENST00000260128.8

Conserved Domains (3) summary

cd16147
Location:42 → 384

G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

pfam12548
Location:534 → 677

DUF3740; Sulfatase protein

cl23718
Location:768 → 817

ALP_like; alkaline phosphatases and sulfatases

RNA

NR_132437.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks multiple 5' exons and contains an alternate 5' terminal exon, and contains an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AB029000, AC091047, BC068565, DB040026
NR_156414.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AF545571, AY101175, DA654454, DB288568
NR_156415.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AF545571, AY101175, CN426828, DA234578
NR_182050.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC013746, AC022790, AC091047
NR_182051.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC013746, AC022790, AC091047
NR_182053.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC013746, AC022790, AC091047
NR_182055.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC013746, AC091047

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

69466781..69660912

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006716442.1 → XP_006716505.1 extracellular sulfatase Sulf-1 isoform X2

See identical proteins and their annotated locations for XP_006716505.1

UniProtKB/TrEMBL

Q6NUJ9

Conserved Domains (2) summary

pfam12548
Location:300 → 435

DUF3740; Sulfatase protein

cl23718
Location:5 → 143

ALP_like; alkaline phosphatases and sulfatases
XM_006716441.1 → XP_006716504.1 extracellular sulfatase Sulf-1 isoform X1

Conserved Domains (2) summary

pfam12548
Location:300 → 435

DUF3740; Sulfatase protein

cl23718
Location:5 → 143

ALP_like; alkaline phosphatases and sulfatases